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Study of degradation of biocompatible copolymers
Oborná, Jana ; Čáslavský, Josef (referee) ; Vávrová, Milada (advisor)
This diploma thesis is focused on biocompatible polymers degradation study. Copolymers were studied based on poly(lactic-co-glycolic) acid and poly(ethylene glycol) PLGA-PEG-PLGA and further these copolymers modified with itaconic acid ITA-PLGA-PEG-PLGA-ITA. This paper investigated the influence of pH phosphate solution on the degradation of polymers. Degradation of polymers occurred at 37 °C in phosphate solution with pH 4.2, 7.4 and 9.2. High performance liquid chromatography with UV-VIS detection of diode-array type was used for quantitative determination of lactic acid and glycolic acid as the final degradation products. For qualitative identification of additional degradation products were used tandem connection liquid chromatography and mass spectrometry. Gel permeation chromatography with refractive index detector was used to determine the molecular weight decrease polymer chain after the degradation.
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Effect of 3D printing technology on the properties of model femur segment
Nečas, Aleš ; Svatík, Juraj (referee) ; Jančář, Josef (advisor)
This bachelor thesis deals with the development of a biodegradable 3D anatomical model of the femur segment and the influence of 3D printing technology on tensile strength and tensile modulus of elasticity of 3D standardized tensile test bodies (ASTM_D_638_IV) made from PLA, nylon, acrylonitrile butadiene styrene (ABS), acrylonitrile styrene acrylate (ASA), polymethyl methacrylate (PMMA), polyethylene terephthalate glycol (PETG), and resin. For each material, bodies with body thickness of 1 mm, 2 mm, and 3 mm were 3D printed. Next, a PLA simplified femur segment model was created to determine the most suitable layer thickness for body printing in terms of its compressive strength and compressive modulus of elasticity. The thickness of the printed layer of 0.1 mm was chosen as the mechanically most suitable and was subsequently used in the production of a PLA anatomical model of the femur segment which was 3D printed in 3 variants differing in the density of the filling of the internal structures in the area of compact and cancellous bone tissue of real bone. Then, the compressive strength of these models was determined and compared. The PLA anatomical model of the femur segment was developed according to CT images of real bone with the purpose of its potential use in medicine as a bone tissue replacement in large femoral defects. However, before it can be used in medicine, further research is needed.
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Effect of 3D printing technology on the properties of model femur segment
Nečas, Aleš ; Svatík, Juraj (referee) ; Jančář, Josef (advisor)
This bachelor thesis deals with the development of a biodegradable 3D anatomical model of the femur segment and the influence of 3D printing technology on tensile strength and tensile modulus of elasticity of 3D standardized tensile test bodies (ASTM_D_638_IV) made from PLA, nylon, acrylonitrile butadiene styrene (ABS), acrylonitrile styrene acrylate (ASA), polymethyl methacrylate (PMMA), polyethylene terephthalate glycol (PETG), and resin. For each material, bodies with body thickness of 1 mm, 2 mm, and 3 mm were 3D printed. Next, a PLA simplified femur segment model was created to determine the most suitable layer thickness for body printing in terms of its compressive strength and compressive modulus of elasticity. The thickness of the printed layer of 0.1 mm was chosen as the mechanically most suitable and was subsequently used in the production of a PLA anatomical model of the femur segment which was 3D printed in 3 variants differing in the density of the filling of the internal structures in the area of compact and cancellous bone tissue of real bone. Then, the compressive strength of these models was determined and compared. The PLA anatomical model of the femur segment was developed according to CT images of real bone with the purpose of its potential use in medicine as a bone tissue replacement in large femoral defects. However, before it can be used in medicine, further research is needed.
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Study of degradation of biocompatible copolymers
Oborná, Jana ; Čáslavský, Josef (referee) ; Vávrová, Milada (advisor)
This diploma thesis is focused on biocompatible polymers degradation study. Copolymers were studied based on poly(lactic-co-glycolic) acid and poly(ethylene glycol) PLGA-PEG-PLGA and further these copolymers modified with itaconic acid ITA-PLGA-PEG-PLGA-ITA. This paper investigated the influence of pH phosphate solution on the degradation of polymers. Degradation of polymers occurred at 37 °C in phosphate solution with pH 4.2, 7.4 and 9.2. High performance liquid chromatography with UV-VIS detection of diode-array type was used for quantitative determination of lactic acid and glycolic acid as the final degradation products. For qualitative identification of additional degradation products were used tandem connection liquid chromatography and mass spectrometry. Gel permeation chromatography with refractive index detector was used to determine the molecular weight decrease polymer chain after the degradation.
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