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Construction Order Management
Saňáková, Miroslava ; Jurkovič, Peter (referee) ; Waldhans, Miloš (advisor)
This diploma thesis solves problems of construction orders management. The key to successful business and stable position in a competitive market is the way of planning, managing and quality processing of construction orders. The aim of this diploma thesis is to describe and analyze the management of a construction order in a selected company, in my case ARCHATT, s.r.o. I also deal with this in this work, namely for the specific order Oprava Severního parkánu a hradeb of Prague Castle. The content of the work is a processed documentation of the supplier's preparation for this order and a detailed description of the entry of construction workers to this daily guarded building.
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Some aspects of molecular mechanisms of xenobiotics' hepatotoxicity and hepatoprotection : Modulatory roles of natural polyphenols
Lekic, Nataša ; Farghali, Hassan (advisor) ; Kršiak, Miloslav (referee) ; Brůha, Radan (referee)
Background & Aims: Oxidative stress and apoptosis are proposed mechanisms of cellular injury in studies of xenobiotic hepatotoxicity. The aim of this work is to find early signal markers of drug-induced injury of the liver by focusing on select antioxidant/oxidant and apoptotic genes. As well, to address the relationship between conventional liver dysfunction markers and the measured mRNA and protein expressions in the D-galactosamine/lipopolysaccharide and tert-butylhydroperoxide hepatotoxicity models. Furthermore, potential hepatoprotective capabilities of antioxidant polyphenols quercetin and curcumin were evaluated in relation to its modulation of the oxidative stress and apoptotic parameters in the given xenobiotic hepatotoxicity models. Methods: Biochemical markers testing the hepatic function included aminotransferases (ALT, AST) and bilirubin. Measurements of TBARS and conjugated dienes were used to assess lipoperoxidation. Plasma levels of catalase and reduced glutathione were used as indicators of the oxidative status of the cell. Real time PCR was used to analyse the mRNA expressions of the inducible nitric oxide synthase (NOS-2), heme oxygenase-1 (HO-1), superoxide dismutase (SOD-1), glutathione peroxidase (Gpx-1), caspase 3 (Casp3), BH3 interacting domain death agonist (Bid) and Bcl-2...
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Construction Order Management
Saňáková, Miroslava ; Jurkovič, Peter (referee) ; Waldhans, Miloš (advisor)
This diploma thesis solves problems of construction orders management. The key to successful business and stable position in a competitive market is the way of planning, managing and quality processing of construction orders. The aim of this diploma thesis is to describe and analyze the management of a construction order in a selected company, in my case ARCHATT, s.r.o. I also deal with this in this work, namely for the specific order Oprava Severního parkánu a hradeb of Prague Castle. The content of the work is a processed documentation of the supplier's preparation for this order and a detailed description of the entry of construction workers to this daily guarded building.
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Analysis of the bidding process of Prague for Summer Olympic Games 2016
Bošková, Linda ; Dovalil, Josef (advisor) ; Kolář, František (referee)
Title: Analysis of the bidding process of Prague for Summer Olympic Games 2016 Objectives: The aim of this thesis is the analysis of Prague's bid for Summer Olympic Games 2016, the following determination of main causes of his failure and than a suggestion of the future steps leading towards the future organisation of Olympic Games. Methods: We have used three managerial methods in this thesis. It was at first the system approach that identifies all stakeholders and their relations, which are all connected. This method permits to understand our subject as a complete system. After that SWOT analysis of the bid and the Fishbone diagram was used to identify main causes of the bid's failure. Results: Main six causes were identified that have caused the failure of the Prague's bid. These causes are more a kind of internal serious problems that show that Prague is not ready yet for organising Olympic Games. Following suggestions for future steps are reacting on these results. The aim of that is to make a long-term strategy to improve the environment and relations between the sport and state and prepare good conditions in the country for the next Olympic bid. Keywords: Olympic Games, bid, causes, sport, Prague, Czech Olympic Committee, International Olympic Committee
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Some aspects of molecular mechanisms of xenobiotics' hepatotoxicity and hepatoprotection : Modulatory roles of natural polyphenols
Lekic, Nataša ; Farghali, Hassan (advisor) ; Kršiak, Miloslav (referee) ; Brůha, Radan (referee)
Background & Aims: Oxidative stress and apoptosis are proposed mechanisms of cellular injury in studies of xenobiotic hepatotoxicity. The aim of this work is to find early signal markers of drug-induced injury of the liver by focusing on select antioxidant/oxidant and apoptotic genes. As well, to address the relationship between conventional liver dysfunction markers and the measured mRNA and protein expressions in the D-galactosamine/lipopolysaccharide and tert-butylhydroperoxide hepatotoxicity models. Furthermore, potential hepatoprotective capabilities of antioxidant polyphenols quercetin and curcumin were evaluated in relation to its modulation of the oxidative stress and apoptotic parameters in the given xenobiotic hepatotoxicity models. Methods: Biochemical markers testing the hepatic function included aminotransferases (ALT, AST) and bilirubin. Measurements of TBARS and conjugated dienes were used to assess lipoperoxidation. Plasma levels of catalase and reduced glutathione were used as indicators of the oxidative status of the cell. Real time PCR was used to analyse the mRNA expressions of the inducible nitric oxide synthase (NOS-2), heme oxygenase-1 (HO-1), superoxide dismutase (SOD-1), glutathione peroxidase (Gpx-1), caspase 3 (Casp3), BH3 interacting domain death agonist (Bid) and Bcl-2...
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