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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Gene expression profiling in diabetic nephropathy
 Nepomucká, Kateřina ; Pavlínková, Gabriela (advisor) ; Černá, Věra (referee)
Diabetic nephropathy (DN) is induced by both type 1 and type 2 diabetes mellitus and it is one of the most serious complications associated with diabetes. Despite increasing incidence of diabetes, the exact pathogenesis remains unclear. Hypoxia is regarded as a crucial factor for the progression of renal disease. The responses to hypoxia are mainly regulated by hypoxia-inducible factor 1 (HIF1). We thus considered a possible link between HIF1-regulated pathways and the susceptibility to DN and the disease progression. We hypothesize that the exposure of renal tissue to diabetes causes gene expression changes in HIF1-regulated pathway and the altered expression profile is decisive for the development of DN. Using mouse model, we analyzed cellular and molecular changes in HIF1 heterozygous-null (Hif1α+/- ) and wild type (wt) littermates exposed to diabetic environment. Our histological analysis showed early pathological changes associated with DN in both diabetic wt and Hif1α+/- compared to non-diabetic controls. The morphological analysis did not demonstrate the effect of Hif1α+/- genotype in comparison to wt. For our molecular analysis with qRT-PCR method, we selected several genes, which were previously associated with pathological processes in kidney diseases. We identified statistically...
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