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Animal models of obsessive-compulsive disorder
Radostová, Dominika ; Stuchlík, Aleš (advisor) ; Kopřivová, Jana (referee)
Obsessive compulsive disorder (OCD) is a widespread chronic psychiatric disorder, presenting itself with a wide range of symptoms. The heterogenity of OCD manifestations hinders the resarch and the interpretation of acquired results. Clinical studies are complemented by new insights collected from studies of animal models of OCD, which are nowdays integral to the resarch of OCD. During the course of the resarch many genetic, behavioral and pharmacologic animal models were developed. Number of works were not worked on further, however some models had been studied for a long time. Evaluation of individual models is dependant on many factors, and therefore the degree of validity and suitability for resarch differs between them. Powered by TCPDF (www.tcpdf.org)
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Role of glutamate in obsessive-compulsive disorder: clinical and experimental findings
Mainerová, Karolína ; Stuchlík, Aleš (advisor) ; Fajnerová, Iveta (referee)
Obsessive - compulsive disorder is a common and chronic illness that decreases quality of life and leads to serious limitations. Its treatment is currently only successful in some patients and many of them remain with their problems without proper help and medication. The exact cause of the disease is not yet known, but the role of the glutamatergic system in the pathophysiology of obsessive-compulsive disorder is apparently very important and its modulation can potentially lead to increase in treatment success. Animal models of genetic, behavioural, pharmacological and optogenetic origins are very useful in gaining new insights into the principles and underlying causes of the disease. Clinical studies indicate the efficacy of glutamatergic modulators for disease manifestations and could serve as new avenues for the development of new drugs. Key words: obsessive-compulsive disorder (OCD); glutamate, animal model, clinical findings
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Animal models of obsessive-compulsive disorder
Radostová, Dominika ; Stuchlík, Aleš (advisor) ; Kopřivová, Jana (referee)
Obsessive compulsive disorder (OCD) is a widespread chronic psychiatric disorder, presenting itself with a wide range of symptoms. The heterogenity of OCD manifestations hinders the resarch and the interpretation of acquired results. Clinical studies are complemented by new insights collected from studies of animal models of OCD, which are nowdays integral to the resarch of OCD. During the course of the resarch many genetic, behavioral and pharmacologic animal models were developed. Number of works were not worked on further, however some models had been studied for a long time. Evaluation of individual models is dependant on many factors, and therefore the degree of validity and suitability for resarch differs between them. Powered by TCPDF (www.tcpdf.org)
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