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The effect of respiratory physiotherapy using Threshold PEP on respiratory functions in people hospitalized after cardiac surgery with access via median sternotomy: a randomized controlled trial
Jandová, Markéta ; Janoušková, Pavla (advisor) ; Pazderáková, Mária (referee)
The main objective: The aim of this study was to evaluate the effect of respiratory physiotherapy with the use of Threshold PEP® device on respiratory function among people hospitalized after cardiac surgery with access via median sternotomy. Methods: During the hospitalization in the Nemocnice České Budějovice a.s. the following measurements were taken - peripheral oxygen saturation (SpO2), maximum inspiratory pressure (MIP), expiratory pressure (MEP) and chest anthropometry. In addition, a questionnaire was used where probands reported their subjective sense of health, including pain and dyspnoe ratings according to the Borg scale. The questionnaire took into account the presence of drainage, cough and associated diseases such as asthma, COPD or COVID-19. Results: The measurement methods proved to be suitable for practical use. The results showed no statistically significant changes in the experimental group in the parameters of MIP (p=0,507), MEP (p=0,339), dyspnoe (p=0,266) and mesosternal flexibility (p=0,076). There was a statistically significant change in xiphosternal flexibility (p=0,0022) and pain (p=0,003). There was a statistically significant change in peripheral oxygen saturation (p=0,014) which was later concluded not to be clinically relevant. Conclusion: During the study,...
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Building Information Modelling of the Water Utility Objects
Maňas, Jaroslav ; Kubíčková, Miroslava (referee) ; Volařík, Tomáš (advisor)
This thesis deals with the BIM creating process with the use of laser scanning data in Revit software. It’s focusing mainly on MEP of water object. In the theoretical part of thesis there are outlined basic issues about laser scanning, informational modelling and other relating issues. In the practical part of the thesis is the summarization of procedure starting from data collecting, data processing to the procedure of creating BIM model, it’s visualisation and the use of the model. There are also mentioned useful pieces of knowledge, which I have learned during dealing with the problems related to the application of this new way of using the spatial information.
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Building Information Modelling of the Water Utility Objects
Maňas, Jaroslav ; Kubíčková, Miroslava (referee) ; Volařík, Tomáš (advisor)
This thesis deals with the BIM creating process with the use of laser scanning data in Revit software. It’s focusing mainly on MEP of water object. In the theoretical part of thesis there are outlined basic issues about laser scanning, informational modelling and other relating issues. In the practical part of the thesis is the summarization of procedure starting from data collecting, data processing to the procedure of creating BIM model, it’s visualisation and the use of the model. There are also mentioned useful pieces of knowledge, which I have learned during dealing with the problems related to the application of this new way of using the spatial information.
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Euroscepticism in the European Parliament: Has the behaviour of the eurosceptic MEPs changed?
Hendrych, Lukáš ; Knutelská, Viera (advisor) ; Stauber, Jakub (referee)
The aim of the bachelor thesis "Euroscepticism in the European Parliament: Has the Behaviour of the Eurosceptic MEPs Changed?" is to analyse political behaviour of eurosceptic MEPs in the European Parliament. The influence and a number of politicians who disagree with European integration and who strongly criticizes it has been getting higher in the last years. It also has an effect on the result of elections to the only directly-voted institution of the European Union. Twice as many of these politicians gained seats in the European Parliament in the elections in 2014 than in 2009. Two political factions that associate MEPs whose position is to be against European integration have also been formed. However, there was only one faction like this in the last legislative term. According to these recent circumstances this bachelor thesis analyses the definition of the term "euroscepticism" and also the behaviour of eurosceptic MEPs. Stronger political representation of this political stance means more possibilities and space for changing these stances to political actions in the European Union. The question remains whether they are going to use their stronger position for their political goals or they will more likely be passive and politically inactive. Powered by TCPDF (www.tcpdf.org)
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Origins of vertebrate hematiopoiesis
Svoboda, Ondřej ; Bartůněk, Petr (advisor) ; Divoký, Vladimír (referee) ; Živný, Jan (referee)
(ENGLISH) Hematopoiesis is dependent on the actions of hematopoietic stem cells (HSCs). This process is tightly controlled through a complex array of extrinsic and intrinsic factors. Even though the hematopoiesis seems to be well conserved across the disparate vertebrate animals, erythroid and thrombocytic differentiation have changed during the evolution of mammals. Specifically, adult mammalian red blood cells have the unique feature of being enucleated, and mammalian thrombocytes are not individual cells, but fragments of megakaryocytes, instead. It is likely that these enhancements provided a survival advantage to early mammalian species; however, they also bring up the question of evolutionary origin of these cells that studied using zebrafish (Danio rerio) model. First, it was necessary to generate a toolbox of a recombinant cytokines and optimized culture media that allowed us to manipulate zebrafish hematopoietic cells ex vivo in liquid and clonal cultures. Interestingly, teleost species underwent an extra duplication event during their evolution and as a result, two copies (paralogs) of some of the genes are present in zebrafish. This was also the case for majority of the cytokines from our toolbox and here, we provide functional characterization of these paralogs. Strikingly, our results...
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