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Effect of antidepressants on placental monoamine homeostasis
Horáčková, Hana ; Štaud, František (advisor) ; Sumová, Alena (referee) ; Soukup, Ondřej (referee)
Charles University, Faculty of Pharmacy in Hradec Kralove Department of Pharmacology and Toxicology Candidate: Mgr. Hana Horackova Supervisor: prof. PharmDr. Frantisek Staud, Ph.D. Title of doctoral thesis: Effect of antidepressants on placental monoamine homeostasis Depression in pregnancy is an increasingly common problem and it is reported that up to 25 % of pregnant women suffer from depression and approximately 13 % are prescribed antidepressants. Currently, the most commonly prescribed antidepressants in pregnancy are selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). However, the safety of these treatments is still controversial, as poor pregnancy outcomes such as organ malformations, increased incidence of neurological disorders, and preeclampsia have been reported in pregnant women taking antidepressants. However, knowledge of the responsible mechanisms is still lacking at present as they have not been sufficiently investigated. Although the effect of antidepressants on the availability of serotonin (5-HT), dopamine (DA) and norepinephrine in brain tissue has been extensively characterized in the literature, the interactions of antidepressants with placental monoamine transporters have not received attention to date. However,...
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Extension of Mobile Application Don't Panic
Snopek, Matúš ; Kapinus, Michal (referee) ; Chlubna, Tomáš (advisor)
The aim of the work is to create an extension to the mobile application \textit{Nepanikar}, which helps users suffering from various mental illnesses. The extension should includes extending the already existing functionality of recording users' moods, then visualizing them using graphs and heatmaps, displaying them in a register of mood records, as well as enhancing specific records. A dark mode is also to be added to give the app a more aesthetically pleasing appearance. The extensions are meant to give users better tools to manage mental health issues.
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Analyzing a person’s handwriting for recognizing his/her emotional state
Chudárek, Aleš ; Matoušek, Jiří (referee) ; Malik, Aamir Saeed (advisor)
Rozpoznávání emocí z rukopisu je náročný a interdisciplinární úkol, který může poskytnout vhled do psychologického a emočního stavu pisatele. V této diplomové práci byl vyvinut a vyhodnocen model strojového učení schopný predikovat emoční stav pisatele na základě vzorků jeho rukopisu. Byl využit dataset EMOTHAW, který obsahuje vzorky rukopisu a kreseb od subjektů, jejichž emoční stavy byly změřeny pomocí testu DASS, který hodnotí úroveň deprese, úzkosti a stresu, a CIU Handwritten databázi pro ověření a experimentování. Bylo extrahováno množství příznaků inspirovaných standardní grafologií, stejně jako příznaky specifické pro online data. Pomocí ANOVA byly vybrány statisticky významné příznaky, které byly normalizovány pomocí Z-Score, MinMax, IQR nebo logaritmické transformace. Dimenzionalita příznaků byla snížena pomocí analýzy hlavních komponent (PCA) a lineární diskriminační analýzy (LDA). Pro klasifikaci byl použit meta-přístup Ensemble learning, který se snaží snížit chyby jednoho jednoduchého modelu využitím rozmanitosti a doplňkovosti více modelů. Struktura klasifikátoru závisí na mnoha argumentech, což vede k více než 300 000 různým konfiguracím. Optimální argumenty a tudíž optimální struktura byla hledána pomocí zamrazování argumentů. Byly identifikovány nejlepší klasifikátory pro binární a trinární klasifikaci každé emoce, což vedlo k šesti optimálním modelům. Tyto modely byly hodnoceny pomocí různých metrik, jako jsou accuracy, precision, recall a F1 Skóre, a dosáhly adekvátních výsledků ve všech metrikách. Kromě nalezení klasifikátorů tato práce zkoumala význam každého extrahovaného příznaku, čímž byl vytvořen seznam nejvýznamnějších příznaků použitých pro rozpoznávání emocí z rukopisu. Dále tato práce rozšiřuje databázi EMOTHAW identifikací úkolů, které jsou více indikativní pro specifické emoce, čímž se snižuje potřeba kompletní baterie úkolů pro emoční analýzu.
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Representation of Mental Illness in Young Adult Literature
SOJKOVÁ, Michaela
The bachelor thesis looks into the representation of psychological disorders in the Young Adult literature. This kind of literary text is targeted primarily at readers within the age group of 12-18 year-olds, but nowadays it is becoming more and more popular among readers of all ages. The thesis researches the motifs of psychological disorders in Young Adult literature, especially the authenticity of representation given the specifics of disorders, and also from the viewpoint of depicting function in the scope of literary text. However, the central theme is a cultural view of how socially taboo topics are represented in literature for adolescent readers, for whom these representations can play key role in an identification of their own troubles and identity.
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Vliv genových polymorfismů na efektivitu farmakologické léčby deprese
MÍČKOVÁ, Dana
The bachelor thesis deals with the possible influence of genetic polymorphisms of selected cytochrome P450 (CYP) genes on the depression or other psychiatric diseases treatment. The treatment of psychiatric patients with psychotropic drugs often turns out to be unsatisfactory due to lack of effectivity or due to adverse drug reactions of psychiatric drugs. This means both a mental strain for the patient and social and economic impacts. One of many influences, participating on the unsatisfactory treatment, are the CYP gene polymorphisms, that result in the same (CYP) named enzymes activity, responsible for the metabolism of the respective drug. Mutation in these genes can cause both gain-of-function and reduced or loss-of-function of the respective enzymes and thus participate on the adverse drug reactions and/or lack of effectivity. The aim of the theoretical part of the thesis was to develop research on the topic of depressive disease, its history and methods of treatment. Moreover, to map the antidepressants prescribing practice in the Czech Republic during the last five years. Other aims were developing of an internet questionnaire for patients and test their genetic polymorphisms in the genes CYP2C19 and CYP2D6 (by the real-time PCR method with the melting curve analysis). Finally, to compare these results (questionnaires and test results) with each other with the aim of finding out whether there is a clear link between the detected type of metabolism and the patient's evaluation of the treatment, an/or whether it is possible to give some recommendations regarding treatment for specific patients.
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Nutrition and cerebral neurodegenerative diseases
Šálková, Michaela ; Vespalcová, Milena (referee) ; Vránová, Dana (advisor)
This bachelor‘s thesis is literary research and its topic is focused on the effect of nutrition on the development of neurodegenerative diseases. The thesis is divided into four parts. The first part deals with the structure and physiology of the human brain. In the second part are described all essential nutrients which the brain needs to maintain its functions. The third part focuses on neurodegenerative diseases and their epidemiology and pathophysiology. In this part are also examined nutrients which could be possibly useful in the prevention or which could be involved in the pathophysiology of the disease. Explored diseases include dementia, Alzheimer’s disease, Parkinson’s disease and unipolar depression.The aim of this thesis was to find accessible literature focused on this topic and make a discussion.
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Mobile application for depressive states monitoring
Kamenská, Veronika ; Bartoň, Vojtěch (referee) ; Škutková, Helena (advisor)
The bachelor thesis named Mobile application for monitoring of depressive states has the goal of creating a functional mobile application using the MIT app inventor. This application offers several tests used to determine the user's mental state and options for sending the data. Part of the thesis is also the development of computer software using Python. This software can be used by psychologists to view and evaluate the patient's mental state. To streamline work between consultations, a part of the thesis also aims to create a PC software that uses the data gathered by the application to help psychologists evaluate the condition. And at the end of the work, to statistically evaluate the test results obtained during the winter semester of 2020.
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Grief
Měchura, Mojmír ; Cseres, Jozef (referee) ; Cenek, Filip (advisor)
Multimedia installation combining photography, music and noises, representing the story of the killer and the victim, from their meeting up to death in five main parts.
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Anthology of Unspoken: Surreal Complexity of Mind
Hrádková, Jana ; Havlíček, Jiří (referee) ; Macháček, Mikuláš (advisor)
The diploma thesis Anthology of Unspoken is a form of personal therapy, a coping mechanism in the shape of an extensive personal research presented by visually eclectic web, which maps the perception of depression and melancholy in terms of historical, artistic, and partly academic discourse. AoU takes the form of a website on the border of an archive and a research blog, which visually reminds a notebook with the use of texts in the form of notes, reader view essays, and accompanying visual material (period paintings, pop-cultural references, emoticons etc.). This diploma thesis has two main goals. Firstly, it represents a way of finding means to articulate and at least fractionally understand my own problems. Secondly, it is a way of finding answers to the following questions: Is depression really a modern matter of the 21st century? Why is it so difficult to talk about it? Where do the shame and feeling of guilt, with which it is inextricably associated with, come from? Is melancholy synonymous with depression, or do these terms differ from each other? And is depression really a disease or is it only a sign of my own failure?
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