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Ion balance and its effect on heart function, measurement and analysis of ECG
Štrbková, Lenka ; Nováková, Zuzana (referee) ; Wilhelm,, Zdeněk (advisor)
Mechanical heart function is based on electrical changes at the level of cardiac cells. These electrical changes are primarily affected by the distribution of ions, intra-and extracellularly. Kidneys are very important for the physiological regulation of ion homeostasis in the body. The ion homeostasis is disrupted in case of the kidney function failure. The aim of this thesis is to compare ion values, acid-base balance before and after dialysis, and also possible changes in ECG time intervals before and after dialysis of these patients. The thesis also deals with the description of the electrocardiographic signals and the implementation of the program for ECG signal analysis. I used the ECG signals from the available database „PhysioBank“ for testing the developed program.
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Software for manual delineation of ECG signals
Jež, Radek ; Kozumplík, Jiří (referee) ; Vítek, Martin (advisor)
This thesis deals with evaluation EKG in terms of classification rhythm and analysis HRV. In theoretic part of work are described basics of heart physiology and its usual pathology, basics of electrocardiography, evaluation EKG and standard methods of HRV evaluation. In practical part are described algorithms used in created application. Mainly describes technique of rhythm evaluation, ectopic rhythms and delineation error elimination, data preparing for HRV evaluation, drift removal from DES and HRV evaluation methods. Created program was tested on CSE and MIT- BIH database records. For lack of suitable data and absence of tested data, it wasn’t possible to test all the classification rules of used algorithms. Tested part of program appears reliable and functional.
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Evaluation of the antineoplastic treatment effects on heart electrical activity in experimental telemetric study
Beňková, Daniela ; Janoušek, Oto (referee) ; Ronzhina, Marina (advisor)
This master´s thesis deals with the analysis of experimental telemetrical ECG records with intention to determine the long-term influence of anticancer drug sunitinib on the electrical activity of heart. A laboratory rat was chosen as a model organism for the experimental study carried out at the Department of Physiology at Faculty of Medicine, Masaryk university. The sunitinib was applied to the rats at an early age and the ECG was measured with a 20-week delay using the Stellar telemetry system. To measure the effect of sunitinib on the electrical activity of the heart chambers, an analysis of the duration of the RR and QT interval and the width of the QRS complex was chosen. These parameters were detected by the wavelet transform method. Statistical analysis was performed using nonparametric tests - the Wilcoxon signed rank test, the MannWhitney test and the Friedman Test. The obtained results suggest that the use of sunitinib has no long-term effect on the observed parameters for the chosen animal model. After extension of the study, the results obtained could contribute to assess the effect of drugs on electrical activity of the human heart several decades after sunitinib treatment termination.
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Analysis of Atrial Fibrillation Heart Rate Dynamics
Tesařová, Tereza ; Ronzhina, Marina (referee) ; Hejč, Jakub (advisor)
Bachalor thesis focuses on clinical tracking of heart rate abnormalities to specify the level of variability in diverse-lengthy ECG signals, with a direct way to analyze atrial fibrillation and accuracy increasing its detection of actual available methods. The principle of heart electrophysiology and also the impulse genesis is mentioned in a introductory part of work, including elementary classification of cardiac arrhytmias and their deflection from normal sinus rhythm. The physiological analysis of atrial fibrilation dynamic structure helps with the application of detection algorithms in a MATLAB program and sets an underlying basis for an appropriate discussion in a final statistical ROC analysis.
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Analysis of long-term electrocardiograms
Vojtíšek, Jiří ; Vítek, Martin (referee) ; Kolářová, Jana (advisor)
This work deals with long-therm analysis of electrocardiogram using heart rate variability representation. Project explains heart anatomy and electrophysiology, creation and shape of ECG curve. Heart rate variability is described by power spectral density, which we obtain from created algorithm. This algorithm was used in graphic user interface application Spider Pig Analysis, which analyze long-term ECG focused on showing Power Spectral Density graph. Practicality of this program was verified in experiment. In the experiment HRV at rest and HRV at tilt were compared.
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P Wave Detection in Pathological ECG Signals
Šaclová, Lucie ; Černý, Martin (referee) ; Tkacz, Ewaryst (referee) ; Vítek, Martin (advisor)
Důležitou součástí hodnocení elektrokardiogramu (EKG) a následné detekce srdečních patologií, zejména v dlouhodobém monitorování, je detekce vln P. Výsledky detekce vln P umožňují získat ze záznamu EKG více informací o srdeční činnosti. Podle správně detekovaných pozic vln P je možné detekovat a odlišit patologie, které současné programy používané v medicínské praxi identifikovat neumožňují (např. atrioventrikulární blok 1., 2. a 3. stupně, cestující pacemaker, Wolffův-Parkinsonův-Whiteův syndrom). Tato dizertační práce představuje novou metodu detekce vln P v záznamech EKG během fyziologické a zejména patologické srdeční činnosti. Metoda je založena na fázorové transformaci, inovativních pravidlech detekce a identifikaci možných patologií zpřesňující detekci vln P. Dalším důležitým výsledkem práce je vytvoření dvou veřejně dostupných databází záznamů EKG s obsahem patologií a anotovanými vlnami P. Dizertační práce je rozdělena na teoretickou část a soubor publikací představující příspěvek autora v oblasti detekce vlny P.
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Analysis of Atrial Fibrillation Heart Rate Dynamics
Tesařová, Tereza ; Ronzhina, Marina (referee) ; Hejč, Jakub (advisor)
Bachalor thesis focuses on clinical tracking of heart rate abnormalities to specify the level of variability in diverse-lengthy ECG signals, with a direct way to analyze atrial fibrillation and accuracy increasing its detection of actual available methods. The principle of heart electrophysiology and also the impulse genesis is mentioned in a introductory part of work, including elementary classification of cardiac arrhytmias and their deflection from normal sinus rhythm. The physiological analysis of atrial fibrilation dynamic structure helps with the application of detection algorithms in a MATLAB program and sets an underlying basis for an appropriate discussion in a final statistical ROC analysis.
|
|
|
Evaluation of the antineoplastic treatment effects on heart electrical activity in experimental telemetric study
Beňková, Daniela ; Janoušek, Oto (referee) ; Ronzhina, Marina (advisor)
This master´s thesis deals with the analysis of experimental telemetrical ECG records with intention to determine the long-term influence of anticancer drug sunitinib on the electrical activity of heart. A laboratory rat was chosen as a model organism for the experimental study carried out at the Department of Physiology at Faculty of Medicine, Masaryk university. The sunitinib was applied to the rats at an early age and the ECG was measured with a 20-week delay using the Stellar telemetry system. To measure the effect of sunitinib on the electrical activity of the heart chambers, an analysis of the duration of the RR and QT interval and the width of the QRS complex was chosen. These parameters were detected by the wavelet transform method. Statistical analysis was performed using nonparametric tests - the Wilcoxon signed rank test, the MannWhitney test and the Friedman Test. The obtained results suggest that the use of sunitinib has no long-term effect on the observed parameters for the chosen animal model. After extension of the study, the results obtained could contribute to assess the effect of drugs on electrical activity of the human heart several decades after sunitinib treatment termination.
|
|
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Ion balance and its effect on heart function, measurement and analysis of ECG
Štrbková, Lenka ; Nováková, Zuzana (referee) ; Wilhelm,, Zdeněk (advisor)
Mechanical heart function is based on electrical changes at the level of cardiac cells. These electrical changes are primarily affected by the distribution of ions, intra-and extracellularly. Kidneys are very important for the physiological regulation of ion homeostasis in the body. The ion homeostasis is disrupted in case of the kidney function failure. The aim of this thesis is to compare ion values, acid-base balance before and after dialysis, and also possible changes in ECG time intervals before and after dialysis of these patients. The thesis also deals with the description of the electrocardiographic signals and the implementation of the program for ECG signal analysis. I used the ECG signals from the available database „PhysioBank“ for testing the developed program.
|
|
|
Analysis of long-term electrocardiograms
Vojtíšek, Jiří ; Vítek, Martin (referee) ; Kolářová, Jana (advisor)
This work deals with long-therm analysis of electrocardiogram using heart rate variability representation. Project explains heart anatomy and electrophysiology, creation and shape of ECG curve. Heart rate variability is described by power spectral density, which we obtain from created algorithm. This algorithm was used in graphic user interface application Spider Pig Analysis, which analyze long-term ECG focused on showing Power Spectral Density graph. Practicality of this program was verified in experiment. In the experiment HRV at rest and HRV at tilt were compared.
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