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Synthesis of deuterium labelled neuroactive steroids.
Slavíčková, Alena ; Chodounská, Hana (advisor) ; Pouzar, Vladimir (referee)
The work si focused on the synthesis of deuterium-labelled neuroactive steroids useful as inner standards for determination of their farmaco-kinetics and bioavailibility. The starting material for the syntheses was comercial 11α-hydroxyprogesterone 16. The target compound, 20-Oxo-[9,12,12-2 H3]5β-pregnan-3α-yl L-glutamyl 1-ester (47), contains 3 deuterium atoms in positions 9α, 12α, 12β. Alternative target with a 18-functionalized group (34) was also studied. It will be used for an analogue with deuterium atoms on carbon C-18.
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Synthesis of deuterium labelled neuroactive steroids.
Slavíčková, Alena ; Pouzar, Vladimir (referee) ; Chodounská, Hana (advisor)
The work si focused on the synthesis of deuterium-labelled neuroactive steroids useful as inner standards for determination of their farmaco-kinetics and bioavailibility. The starting material for the syntheses was comercial 11α-hydroxyprogesterone 16. The target compound, 20-Oxo-[9,12,12-2 H3]5β-pregnan-3α-yl L-glutamyl 1-ester (47), contains 3 deuterium atoms in positions 9α, 12α, 12β. Alternative target with a 18-functionalized group (34) was also studied. It will be used for an analogue with deuterium atoms on carbon C-18.
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