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The Imaging of Brain Pathological Lesions in Systemic Lupus Erythematosus Patients
Podrazilová, Lucie ; Dostál, Ctibor (advisor) ; Hrnčíř, Zbyněk (referee) ; Seidl, Zdeněk (referee)
Objective: Our project study presents the results of measuring the volume of pathological foci in the brain tissue of patients suffering from systemic lupus erytematodes (SLE) with or without neuropsychiatric manifestations (NP). Magnetic resonance (MR) scans of patients with SLE and, in particular, signs of neuropsychiatric involvement show pathological foci in the cerebral white matter. Methods: A total of 53 SLE patients, 29 with signs of neuropsychiatric syndromes (NPSLE), 24 without, and 16 healthy controls underwent prospective volumetric magnetic resonance imaging in a flow attenuated inversion recovery (FLAIR) sequence. The disease activity was expressed in terms of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Results: All of the patients in this study were found to have a larger volume of pathological foci in the brain tissue than the healthy controls. The NPSLE subgroup had a larger volume of pathological foci than the SLE patients without NP (p<0.001). The largest volume of such foci was found in patients with a history of cerebrovascular disease (p<0.05). These were also noted for a correlation between the duration of the disease and the period of time elapsed from the onset of the first signs of neuropsychiatric lupus (p<0.01). Correlation with SLEDAI-rated disease activity...
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The physical load on the body as a factor influencing perceptual cognitive functions
Frýbort, Pavel ; Süss, Vladimír (advisor) ; Tomajko, Dušan (referee) ; Seidl, Zdeněk (referee)
Title: The physical load on the body as a factor influencing perceptual cognitive functions. Objective: The aim of this study is to determine the relationship between the size of the physical load and the visual-motor response time and the accuracy of the decision-making by junior soccer players. Methods: The fourty two respondents (in an average age of 19 ± 1.2 years) participated in the study. It was the single factor quasiexperimental, multilevel and intragroup in which we tried to reveal the causal relationship between the visual-motor response time and the accuracy of the decision-making depending on the size of the previous physical load. We proposed a diagnostic instrument containing the video of the offensive game situations which would allow simultaneous evaluation of the visual-motor response time (using Dartfish software program) and the accuracy of the decision-making (through experts assessment). Results and discussion: The diagnostic instrument contains sixteen video clips of the offensive game situations according to the highest degree of conformity of the panelists. I used polychoric correlation matrix to express dependencies between each game situation within each group comprising four video clips of the offensive game situations. The results of the matrix (range -0.437 to 0.306)...
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The physical load on the body as a factor influencing perceptual cognitive functions
Frýbort, Pavel ; Süss, Vladimír (advisor) ; Tomajko, Dušan (referee) ; Seidl, Zdeněk (referee)
Title: The physical load on the body as a factor influencing perceptual cognitive functions. Objective: The aim of this study is to determine the relationship between the size of the physical load and the visual-motor response time and the accuracy of the decision-making by junior soccer players. Methods: The fourty two respondents (in an average age of 19 ± 1.2 years) participated in the study. It was the single factor quasiexperimental, multilevel and intragroup in which we tried to reveal the causal relationship between the visual-motor response time and the accuracy of the decision-making depending on the size of the previous physical load. We proposed a diagnostic instrument containing the video of the offensive game situations which would allow simultaneous evaluation of the visual-motor response time (using Dartfish software program) and the accuracy of the decision-making (through experts assessment). Results and discussion: The diagnostic instrument contains sixteen video clips of the offensive game situations according to the highest degree of conformity of the panelists. I used polychoric correlation matrix to express dependencies between each game situation within each group comprising four video clips of the offensive game situations. The results of the matrix (range -0.437 to 0.306)...
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název v anglickém jazyce není uveden
Fischerová, Daniela ; Cibula, David (advisor) ; Rešlová, Taťána (referee) ; Seidl, Zdeněk (referee)
Ultrazvukem navigovaná biopsie silnou jehlou je bezpečná, rychlá a spolehlivá metoda k histologické verifikaci pokročilého nebo recidivujícího abdominopelvického nádoru. Výkon lze provést ambulantně, bez nutnosti celkové anestézie, při minimálním dyskomfortu pro pacienta ve srovnání s laparoskopií nebo laparotomií. Riziko komplikací je nízké a hlavní výhodou je získání adekvátního histologického vzorku s možností následného imunohistochemického vyšetření, které je nezbytným předpokladem pro volbu optimální onkologické léčby.
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The Imaging of Brain Pathological Lesions in Systemic Lupus Erythematosus Patients
Podrazilová, Lucie ; Dostál, Ctibor (advisor) ; Hrnčíř, Zbyněk (referee) ; Seidl, Zdeněk (referee)
Objective: Our project study presents the results of measuring the volume of pathological foci in the brain tissue of patients suffering from systemic lupus erytematodes (SLE) with or without neuropsychiatric manifestations (NP). Magnetic resonance (MR) scans of patients with SLE and, in particular, signs of neuropsychiatric involvement show pathological foci in the cerebral white matter. Methods: A total of 53 SLE patients, 29 with signs of neuropsychiatric syndromes (NPSLE), 24 without, and 16 healthy controls underwent prospective volumetric magnetic resonance imaging in a flow attenuated inversion recovery (FLAIR) sequence. The disease activity was expressed in terms of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Results: All of the patients in this study were found to have a larger volume of pathological foci in the brain tissue than the healthy controls. The NPSLE subgroup had a larger volume of pathological foci than the SLE patients without NP (p<0.001). The largest volume of such foci was found in patients with a history of cerebrovascular disease (p<0.05). These were also noted for a correlation between the duration of the disease and the period of time elapsed from the onset of the first signs of neuropsychiatric lupus (p<0.01). Correlation with SLEDAI-rated disease activity...
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Sec. Progressive Form of Multiple Sclerosis : Brain Atrophy and Leasion Load in MRI
Mašek, Martin ; Seidl, Zdeněk (advisor) ; Süssová, Jana (referee) ; Lisý, Jiří (referee)
Secondary progressive form of multiple sclerosis (SPMS) is characterized by a steady progression of clinical neurological damage with or without superimposed relapses and minor remissions and plateaus. Patients who develop SPMS will have previously experienced a period of RRMS, most of the untreated patients with RRMS will go on to develop SPMS in 10-20 years, time to transition is prolonged with a proper therapy. Based on clinical status alone, it is difficult to precisely establish when RRMS converts to SPMS although it is clearly important for appropriate treatment. The aim of the study was to monitor the interaction between the clinical manifestation of the SPMS expressed in the Expanded Disability Status Scale (EDSS) and abnormal findings in magnetic resonance imaging (MRI) of the brain. Twelve patients diagnosed with SPMS were included in this study, once a year the evaluation of the clinical status of the patient expressed in EDSS was performed, usually at the time of MRI examination. All patients underwent a MRI examination every 12 months for 3 years. Utilizing a special program developed in our Institution , the following parameters were evaluated during each MRI examination: brain tissue volume (brain atrophy status), lesion load in FLAIR sequence, volume of ""black holes"" (volume of...
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