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Oxidative phosphorylation addiciton as a new approach to the therapy of neoplastic diseases
Růžičková, Anna ; Neužil, Jiří (advisor) ; Merta, Ladislav (referee)
Neoplastic diseases belong at present time among the most frequent causes of premature death in industrialized countries. Discovery of novel approaches to their therapy is highly warranted. Recent results point to the requirement of mitochondrial respiration for tumor progression. This is linked primarily to recent discovery of horizontal transfer of mitochondrial transfer from the host to cancer cells with damaged mitochondrial DNA. This is a needed for the recovery of mitochondrial respiration, a prerequisite for tumor progression. It has appeared that the rate of respiration necessary for tumor progression differs in individual types of tumors. This hypothesis, which is refer to as 'oxidative phosphorylation addiction', however, needs to be verified. It could serve as the basis for proposing of novel therapic strategy for neoplastic diseases, using compounds that directly affect mitochondrial respiratory complexes. Key words: mitochondria, oxidative phosphorylation, horizontal transfer of mitochondrial DNA, neoplastic pathologies, mitochondrially targeted anti-cancer agents
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Comparison of olympic broadcasting on czech television from winter olimpic games 2010 and 2014
Růžičková, Anna ; Kruml, Milan (advisor) ; Bednařík, Petr (referee)
This thesis principally compares the Olympic broadcasting on the Czech Television covering Winter Olympic Games 2010 in Vancouver and 2014 in Sochi. The first part of the text defines the concept of Olympism, the history of the Olympic Games and the Czechoslovak Olympic Committee, and the current form of the Games and their future. The further analysed Winter Olympics 2010 and 2014 are being briefly described in this section as well. Moreover, the relationship between sport and media, and the media event of the Olympic Games are being defined. Considerable attention is being given to the Olympic Television Broadcasting. Consequently, the history of broadcasting, broadcasting rights, commercialization of the Olympics, their funding, and the function of Olympic Broadcasting Services is being discussed too. The latter part is devoted to the Czech Television, its history and current form as a public service broadcaster. The chapters that deal with an analysis of Olympic broadcasting covering Vancouver and Sochi describe the Olympic teams of the Czech Television in Prague and in the Olympic venue, program schedules, and web specials. The number of broadcasted hours from the Olympics, the costs of broadcasting production, and the viewership are being compared. The Olympic broadcasting from Vancouver was...
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Comparasion of Marketing Communications of Tour Operator Trip and Tour Operator Kudrna
Růžičková, Anna ; Dolanská, Nora (advisor) ; Klabíková Rábová, Tereza (referee)
Bachelor thesis "Comparison of marketing communications of tour operator Trip and tour operator Kudrna" describes and analyses marketing activities and tools employed by two tour operators: Trip and Kudrna. The focus of this thesis is the comparison of marketing communications of both subjects. Compared elements are demonstrated through the marketing mix, communication mix, SWOT analysis and corporate identity. The key communication tools analyzed in this work are online presentations and printed catalogues of the tour operators. The focal point of this work is marketing communication, which is based on the entire character of organizations and is linked to their history, products, services, corporate culture, etc. In order to improve the analysis of the subject, the work covers each of the areas individually.
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Firm Analysis by Different Methods
Růžičková, Anna ; Ing.Antonín Levíček (referee) ; Hanušová, Helena (advisor)
The Bachelor thesis is focused on evaluating the overall financial position of company operating in the construction industry. The aim of the thesis is to analyze this situation by specific methods and provide proposals for its improvement. The first section describes the various methods and theoretical basis for the elaboration of fundamental and financial analysis. In the second part, the different methods are applied and in the last section the key recommendations for improvement are presented.
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