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The role of protein kinase C in the pathogenesis of insulin resistance and its complications
Marková, Irena ; Novák, František (advisor) ; Zeman, Miroslav (referee) ; Zídková, Jarmila (referee)
18 effects of TZDs are probably due to the remodeling of adipose tissue and increased adiponectin secretion. SUMMARY Studying the pathogenesis of insulin resistance and the role of PKC in insulin resistance In HHTg rats, elevated serum triglycerides and FFA were associated with the ectopic accumulation of triglycerides in tissues and reduced insulin sensitivity of peripheral tissues. Impaired glucose utilization in the peripheral tissues was associated with the reduced activity of GS in skeletal muscle. Decreased GS activity and glucose utilization in peripheral tissues indicate a possible defect in insulin signal transduction. In line with this, our results show that skeletal muscle IR was associated with the increased activation and translocation of PKC θ. Nutritionally induced obesity of HHTg rats resulted, in many cases, in the further deterioration of metabolic abnormalities associated with IR. We found that PKC θ, in particular, could contribute to the metabolic abnormalities associated with IR and obesity. The age-related increase in IR and deterioration of some parametres of carbohydrate and lipid metabolism, were not associated, in HHTg rats, with obesity but with increased serum levels of triglycerides and FFA. The age-related worsening of IR in HHTg rats was accompanied by increased...
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Malnutrition in the Critical Care
Fučíková, Olga ; Novák, František (advisor) ; Meisnerová, Eva (referee)
Graduation theses is focused on malnutrition of patients on ICU and consecutively on their treatment. Generally valid rules of use of the clinical nutrition including ESPEN guidelines are mentioned in theoretical part. Empirical part in detail focuses on energy and protein intake of patients on metabolic ICU as well as on surgical ICU in Hospital Tábor and General Faculty Hospital in Prague. It compares "regional" and faculty hospital and also compares general medicine versus surgery.
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Comprehensive care for a patient with acute necrotizing pancreatitis
Černá, Věra ; Výborný, Josef (advisor) ; Novák, František (referee)
Master's thesis "Comprehensive care of patients with acute necrotizing pancreatitis" is divided into two main parts: theoretical one and a practical one. The theoretical part deals the characteristics of an acute pancreatitis, pancreas history knowledge, aetiology, pathophysiology, classification, clinical picture, diagnosis, therapy and possible complications of acute pancreatitis. In the practical part there are described two cases of the acute necrotizing pancreatitis disease. The first case is solved by the conservative way and the second one by a surgical method.
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Biogas Plant Telč
Novák, František ; Hubáček,, Petr (referee) ; Myslín, Jiří (advisor) ; Skála, Jiří (advisor)
The biogas plant in Telč. Administrative and laboratory building is located on the premises of a biogas plant on the outskirts of Telč in the field of science and technology park. Half of a two-storey building will be used for laboratory tests which, under different operating conditions and settings will test changing input of crops, optimization of these parameters in different technological settings to maximize energy output. It will also be a place of management of biogas plant. The building is located in a slightly hilly terrain at an altitude of 539,350 meters and complies with disabled access.
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Law-Related Databases
Novák, František ; Cvrček, František ; Pala, K. ; Rychlý, P.
The Legal Theory Dpt. of the Institute of State and Law has been running and processing databases since 1985. Their primary purpose is the research and analysis of legal texts and legal language. In principle, they involve two projects: CS LEGSYS (the database of legal regulations, judicature and bill justification reports), and PES (Legal Electronic Vocabulary) – the database of doctrinal language (textbooks, comments and laws) complemented by a linguistic module for the analysis of law-related reference publications and their comparison with the general language. All relevant software tools for work with the Legal Electronic Vocabulary have been developed in cooperation with the Informatics Faculty of Masaryk University.
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Study of structure and chemical composition of soil humic substances isolated from humic podzol
Enev, V. ; Klučáková, M. ; Novák, František
The aim of this work was study chemical composition and structure of soil humic substances (HS). Object of our study were three samples HS which were isolated from Humic Podzol (locality Krkonoše, Czech Republic). Isolation of HS was performed according to the procedure recommended by the International Humic Substances Society. All samples of HS were characterized by elemental analysis (EA), ultraviolet-visible spectroscopy (UV/Vis), infrared spectroscopy (FTIR) and steady-state fluorescence spectroscopy. Absorption coefficients (E.sub.ET./sub./E.sub.BZ./sub., E.sub.2./sub./E.sub.3./sub. and E.sub.4./sub./E.sub.6./sub.) of HS were calculated from the absorbance values. Fluorescence coefficients (Milori index and Zsolnay index) of HS were calculated from the area of the emission spectra.
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Quo vadis, Czech Legislation - Laws of the Czech Republic since 1993 and Factually Subject Characteristics
Novák, František
This chapter is concerned of the analysis of the Czech legislation from the year 1993 to the present in category of Law Acts as the basic legislative instrument enected in that period. The results obtained from such comparisons demonstrate that the most intensive attention is in legislation devoted to economic and state administrative affairs including justice, but problems connected with individual and his rights and possible satisfying his cultural, social and education needs are after the year 1990 even more marginalized.
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Positive influence of humate on the growth of selected plant species
Šerá, Božena ; Novák, František ; Gajdová, Iveta
Stimulatory effect of humic and fulvic acids extracted from local sources of peat (the origin of CR) on germination and early growth of hemp (Cannabis sativa L.), poppy (Papaver somniferum L.), pepper (Capsicum annuum L.) and rape (Brassica napus subsp. napus) was verified. Experiments were performed in standard laboratory conditions. Dry weight of sprout was determined. Obtained data were evaluated by the ANOVA test. Tested plants can be arranged in the order from the significant positive effect on the dry weight to the negative one as follows: hemp, poppy, pepper, rape.
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