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Atrial Fibrillation - Morphological and Electrophysiological Changes of the Atrial Myocardium
Matějková, Adéla ; Šteiner, Ivo (advisor) ; Mandys, Václav (referee) ; Pařízek, Petr (referee)
Atrial fibrillation - morphological and electrophysiological changes of the atrial myocardium Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, was considered as pure functional disorder for long time. In recent years, there were identified atrial locations, which are involved in the initiation and maintenance of this arrhythmia. These structural changes, so called remodelation, start at electric level and later they affect contractility and morphology. We attempted to find a possible relation between morphological (scarring, isolated atrial amyloidosis (IAA), left atrial (LA) enlargement) and electrophysiological (ECG features) changes in patients with AF. We examined grossly and histologically 70 hearts of necropsy patients - 44 with a history of AF (subclassified into two subgroups: PERM - patients with permanent or persistent AF - 20, and PAROX - patients with paroxysmal and newly diagnosed AF - 24), and 26 control cases without any history of AF. Premortem ECGs were evaluated. The patients with AF had significantly heavier hearts, larger LAs, more advanced fibrosis in atrial myocardium and more severe amyloidosis in both atria. The hearts of the PERM subgroup were the most affected. Severity of amyloidosis was significantly higher in the left vs. right atria. Distribution...
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The Pharmaceutical Lobby in the Czech Republic
Škrobáková, Irena ; Vymětal, Petr (advisor) ; Matějková, Adéla (referee)
The pharmaceutical companies are considered as one of the most influential interest groups within drug policy, or in general within healthcare system. Therefore, this diploma thesis is focused on the influence of the pharmaceutical manufacturers on legislative framework that forms the drug policy, on the impact on the concrete implementation of drug policy and finally on the influence on prescription, sales and public opinion. Based on an analysis of the pharmaceutical market and the drug policy of the Czech Republic, the diploma thesis defines the most common interests of the pharmaceutical companies which they are trying to push through lobbying. Furthermore, the thesis identifies the access points through which these interests can push through and tries to illustrate these facts on concrete examples.
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Activities of interest groups in the area of GMO: a case study of genetically modified maize
Nekovařík, Tomáš ; Vymětal, Petr (advisor) ; Matějková, Adéla (referee)
This thesis deals with promoting of the interests in the area of genetically modified organisms. The aim is to analyze the activities of interest groups in the area and affect different approach of governments to GMO in the USA and Europe. The work is structured into four parts. The first chapter theoretically defines interest groups and lobbying. The second chapter is devoted to genetically modified organisms and the differences between the EU and the USA in the legislation, the extent of cultivation and the approach of governments. The third chapter deals with Monsanto - the company that dominates the amount of interest groups in this area. The fourth chapter presents a case study of the problem of genetically modified maize in Europe. Just on the case of genetically modified maize can be seen in the European Union activities interest groups, approach of member states and European Union approach.
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Lze normalizovat zahraniční vztahy mezi Spojenými státy americkými a Íránem?
Matějková, Adéla ; Druláková, Radka (advisor) ; Matějka, Zdeněk (referee)
This thesis tries to identify what's at stake of normalized relations between the United States and Iran since the Iranian revolution in 1979. The thesis tries to find out what are the key issues behind the failed relations between these two countries from the American point of view in order to determine whether normalized relations between these two countries can ever be achieved. It elaborates on four key characteristics of individual level analysis of foreign policy decision making applied on three key Presidents involved in foreign policy making towards Iran since 1979.
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