Home > Search Results: Klézl, Petr
Search:
Search Tips :: Advanced Search
Search collections:
Sort by: Display results: Output format:
National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Rare cells in diagnostics and monitoring of gynecological diseases
 Kiss, Imrich ; Bobek, Vladimír (advisor) ; Špaček, Jiří (referee) ; Klézl, Petr (referee)
In the last two decades there is an enormous effort to discover a non-invasive marker to diagnose, predict and monitor therapy effect of malignant diseases. Circulating tumor cells (CTC) have the ability to fulfil all these criteria. The introduction of the monothematic thesis deals with the problematics of CTC in general and its application in clinical medicine. It is followed by the author's first publication, which reviews the current status of CTC in gynecological malignancies. The next publication is an original article about CTC in patients with endometrial carcinoma. It reports a successful isolation of vital CTC in 75% of tested patients and identifies CTC as an individual marker of the disease without correlation to the stage, grade or lymph nodes involvement. The second part of this thesis deals with endometriosis, a benign but often recurrent disease worsening the life quality of women in reproductive age. The multicentre study presents a successful isolation of circulating endometrial cells (CEC) in patients with histologically proven endometriosis with various stages and symptoms. From the total of 423 samples 78.4% were CEC positive. Eleven patients were monitored during their menstrual cycle and CEC tested in different phases, being the early post-ovulatory period in which the...
Detailed record
The possibility of setting diagnostic and therapeutic algorithms for screening and effective treatment of kidney tumours as prevention of treatment failure.
 Klézl, Petr ; Grill, Robert (advisor) ; Broďák, Miloš (referee) ; Záťura, František (referee)
Renal cell carcinoma (RCC) is the third most common urological malignancy, in which about 30% are diagnosed with a metastatic disease at the time of diagnosis. Due to radiation resistance and chemoresistance, the prognosis of these patients is poor. Therefore, the optimal treatment is complete removal of the tumor from at the stage of localized disease. The prognosis of patients has improved in recent decades due to an increase in the number of incidentally detected kidney tumors and also the introduction of new types of treatments. Given the general trend of increasing randomly diagnosed kidney tumors, we were inspired to evaluate patients operated for kidney cancer with respect to the type of disease detection and the method of primary examination. The fact that we do not have a biomarker corresponding to the treatment or recurrence of the disease for monitoring patients after kidney cancer surgery led us to the CTC investigation. CTC examination belongs to the group of liquid biopsy tests and one of its main advantages is the relatively minimal invasiveness (blood collection), which really allows monitoring of tumor dynamics. The primary question was whether CTC cells could play a role in monitoring patients after surgery and event. In the setting of immunotherapeutic and antiangiogenic treatment...
Detailed record

Interested in being notified about new results for this query?
Subscribe to the RSS feed.
Digital Repository :: Search :: Submit :: Personalize :: Help
Powered by Invenio v1.1.2
Maintained by admin.invenio@techlib.cz
This site is also available in the following languages:
Česky  English