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Design of the North Junction from Hranice na Morave to HSR Line
Gelová, Zuzana ; Janoušek, Jan (referee) ; Dušek, Erik (advisor)
The aim of this master’s thesis is the design of railway junction from high-speed rail RS1 Bohumín – Přerov to railway station Hranice na Moravě at a speed 160 of kph. The design has been developed with minimisation of land occupation and the minimisation of engineering structures. The next aim is the design of two pairs of railroad switch on the high-speed rail. Part of the thesis is the design of the railway substructure, railway superstructure and track drainage.
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Design of Pardubice Connection from HSR Line
Kuchár, Martin ; Janoušek, Jan (referee) ; Dušek, Erik (advisor)
The aim of the work was to design the railway connection of the city of Pardubice to the VRT network Prague - Hradec Králové - Wroclaw. The beginning of the connection is to be located near the village of Olešnice. The end of the connection is to be located near the village of Opočínek on a conventional line in front of the railway stop Pardubice - Opočínek. The new VRT route is to be designed for a maximum speed of 350 km / h according to the DÚR Design Manual. The length of the route should be about 20 km.
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Hrusovany n/J - Znojmo Track Modernization Study
Dvořák, Dominik ; Janoušek, Jan (referee) ; Říha, Tomáš (advisor)
The theme of the Bachelor thesis is modernization of railway line Hruš - Znojmo. The project includes assessment of possibility of increasing the critical running speed up to 200 km/h and its implementation on current track structure. Current track geometry, including its vertical and horizontal alignement, has been modified and the implementation of the line speed verified according to valid standards and regulations base on ČSN 73 6360-1.
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Studium of the clinical impact of different forms of cardiac resynchronisation therapy by patients with chronic heart failure
Burianová, Lucie ; Kautzner, Josef (advisor) ; Janoušek, Jan (referee) ; Táborský, Miloš (referee)
Studium of the clinical impact of different forms of cardiac resynchronization therapy by patients with chronic heart failure MUDr. Lucie Burianová ABSTRACT: Introduction: Biventricular (BiV) pacing decreases mortality and improves quality of life of patients with severe heart failure. Haemodynamic and short time clinical studies suggest that isolated leftventricular pacing could have the same effect. Aims: Compare the effect of BiV and leftventricular pacing by subjects with dilated cardiomyopathy and severe heart failure with the attention to signs of dyssynchrony and remodelation of the left chamber. In methodical substudy compare the results of left chamber volumes and ejection fraction (EF LK) measured by CT angiography and 2-dimensional echocardiography with use of contrast agent (K-ECHO). Methods: Patients indicated for cardiac resynchronization therapy were randomized for either BiV or leftventricular pacing. After implantation of the device they were examinated clinically and by echocardiography every 3 months in the period of one year. Four years from the onset of the study the major adverse events in both groups were evaluated. The results of left chamber volumes and EF LK measured by K-ECHO and CT angiography were compared. Results: We enrolled 33 patients. We found clinical improvement in both...
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The impact of positive inotropic and antiarrhythmic drugs on cardiovascular system
Kočková, Radka ; Linhart, Aleš (advisor) ; Janoušek, Jan (referee) ; Štengl, Milan (referee)
Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo A significant increase in cardiovascular medication use during pregnancy has occurred in recent years but only limited evidence on its safety profile is available. We hypothesized that drug-induced bradycardia is the leading mechanism of developmental toxicity. We tested metoprolol, carvedilol, or ivabradine for embryotoxicity and their acute effect on chick embryonic model. We used video microscopy and ultrasound biomicroscopy. Significant dose-dependent mortality was achieved in embryos injected with carvedilol and ivabradine. In ED4 embryos, metoprolol, carvedilol and ivabradine reduced the heart rate by 33%, 27%, and 55%, respectively, compared to controls (6%). In ED8 embryos this effect was more pronounced with a heart rate reduction by 71%, 54%, 53%, respectively (controls 36%). Cardiac output decreased in all tested groups but only proved significant in the metoprolol group in ED8 embryos. The number of -adrenergic receptors showed a downward tendency during embryonic development but a negative chronotropic effect of tested drugs was increasingly pronounced with embryonic maturity. This effect was associated with reduced cardiac output in chick embryos, probably leading to premature death....
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Study of the highspeed line Hradec Králové - state border CZ/PL
Talapka, Filip ; Janoušek, Jan (referee) ; Plášek, Otto (advisor)
The aim of this master's degree thesis is a design the route of the high-speed railway line between Hradec Králové - state border CZ/PL. The section starts near the town of Jaroměř and ends at the state border of CZ / PL, near the village of Petříkovice. The proposal is developed in two basic variants, variant nr. 1 only for passenger traffic and variant nr. 2 for mixed traffic of passenger and freight transport. Part of both variants is the design of the exit to the conventional network near the town of Trutnov, enabling its connection to the high speed railway in the direction of Hradec Králové - Trutnov. Part of the work is also the calculation of investment costs for the implementation of individual variants.
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Railway Station Podebrady HSR
Piruš, Erik ; Janoušek, Jan (referee) ; Dušek, Erik (advisor)
The master´s thesis deals with the design of the transfer terminal on the proposed high speed railway Prague - Hradec Kralove - Wroclaw near the town of Podebrady and exit 39 from the D11 motorway. The work includes the design of station layout, platforms, access roads, bus stops and parking house. As part of the railway station design naintenance base with the loading area. The integral parts of the thesis is design of the railway superstructure, substructure and drainage system.
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Design of junction point Jistebník
Talapka, Filip ; Janoušek, Jan (referee) ; Plášek, Otto (advisor)
The aim of this bachelor thesis is to design a rail connection between the corridor track Přerov – Ostrava and a high-speed track Přerov – Ostrava near the village Jistebník. The flyover interconnections are designed in all four directions for a maximum speed of 160 km / h. The proposal is divided into two basic variants – the minimization of land occupation and the minimization of engineering objects.
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Bělotín Junction and Passing Point Study
Piruš, Erik ; Janoušek, Jan (referee) ; Dušek, Erik (advisor)
The bachelor's thesis is focused on design of the separated level connection of the High speed line Prerov - Ostrava to the conventional line Prerov - Ostrava near Hranice na Morave station (connected from the Ostrava side). The thesis should include the track geometry design of the conventional line and design of the Belotin Junction, consisting of two overtaking tracks, each one for one of the directions.
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