|
|
Competitive Intelligence in pharmaceutical industry
Hubálková, Pavla ; Papík, Richard (advisor) ; Horváth, David (referee)
This diploma thesis describes and analyzes an area of competitive intelligence in the pharmaceutical industry. The work is divided into five parts. The first part deals with competitive intelligence and related aspects, the second part is dedicated to the pharmaceutical industry, with all specifics. The third part deals with competitive intelligence in the intersection with the pharmaceutical industry, the fourth part contains the classification and description of information resources appropriate for the activities of CI and a fifth part presents research, which consists of a questionnaire survey among pharmaceutical companies on the state of competitive intelligence and semi-structured interview with an expert in the area of CI in pharmaceutical company. The survey results represent a certain sub-probe, which demonstrates the strong position of CI as a common standard of pharmaceutical companies. Keywords competitive intelligence, pharmaceutical industry, information needs, drugs, pharmacovigilance, patents, information resources
|
|
|
Study of functional and pharmacological properties of NMDA receptors
Hubálková, Pavla ; Vyklický, Ladislav (advisor) ; Horáček, Jiří (referee) ; Novotný, Jiří (referee)
Pavla Hubalkova Doctoral study program: Neuroscience, 2021 Doctoral thesis: Study of functional and pharmacological properties of NMDA receptors ABSTRACT N-methyl-D-aspartate (NMDA) receptors are a subtype of ionotropic glutamate receptors crucial for synaptic transmission and learning and memory processes. After activation and opening of the ion channel, they are permeable to calcium ions (Ca2+ ) that mediate further signaling. Hypo- or hyperfunction of NMDA receptors leads to the development of severe neurological and psychiatric diseases. NMDA receptors are modulated by many endogenous and exogenous substances. These include neurosteroids - steroids synthesised de novo in the central nervous system and their synthetic analogues, which, depending on their structure, can have positive or negative modulatory effects. Using electrophysiological and molecular-biological techniques, we have clarified the molecular mechanism of increased sensitivity of NMDA receptors to inhibitory neurosteroids following a transient increase in intracellular Ca2+ concentration. The increase in neurosteroid inhibitory activity at NMDA receptors is related to Ca2+ -induced depalmitoylation of three cysteines (C849, C854, C871) in the intracellular part of the GluN2B subunit. This simultaneously leads to a change in the receptor's...
|
|
|
Competitive Intelligence in pharmaceutical industry
Hubálková, Pavla ; Papík, Richard (advisor) ; Horváth, David (referee)
This diploma thesis describes and analyzes an area of competitive intelligence in the pharmaceutical industry. The work is divided into five parts. The first part deals with competitive intelligence and related aspects, the second part is dedicated to the pharmaceutical industry, with all specifics. The third part deals with competitive intelligence in the intersection with the pharmaceutical industry, the fourth part contains the classification and description of information resources appropriate for the activities of CI and a fifth part presents research, which consists of a questionnaire survey among pharmaceutical companies on the state of competitive intelligence and semi-structured interview with an expert in the area of CI in pharmaceutical company. The survey results represent a certain sub-probe, which demonstrates the strong position of CI as a common standard of pharmaceutical companies. Keywords competitive intelligence, pharmaceutical industry, information needs, drugs, pharmacovigilance, patents, information resources
|
|
|
Information flow management in Municipal Library Ústí nad Orlicí
Hubálková, Pavla ; Dombrovská, Michaela (advisor) ; Sluková, Petra Zia (referee)
This bachelor's thesis deals with information flow management in libraries. The thesis consists of two parts - theoretical and practical. In the theoretical part, there are defined terms related to information and knowledge management, and subsequently there are described particular information flows in libraries. The practical part consists information flow analysis in the Municipal library Usti nad Orlici using the content analysis and semi-structured interview methods. The result of analysis brings evaluation of quality of information flows in the above mentioned library and concrete proposals for its improvement. Keywords information flow, information management, knowledge management, libraries, information strategy, organizational culture, information barrier, information noise
|
guest ::
RSS feed.