|
|
Growth of the Czech breastfed children at the age of 0-12 months
Riedlová, Jitka ; Schneidrová, Dagmar (advisor) ; Hrstková, Hana (referee) ; Sedlak, Petr (referee)
In the last decade, there is a growing focus of health professionals on growth of children and their mode of feeding in the early age. According to the WHO global public health recommendation, infants should be exclusively breastfed for the first six months and thereafter should receive nutritionally adequate and safe complementary foods while breastfeeding continues up to two years or beyond. In 2006, the WHO published growth standards and recommended their using for the assessment of growth of children up to the age of 5 years. The Czech Republic has a long-term tradition of its own nation-wide anthropological surveys (CAS) which provide data for constructing reference growth charts to be used for evaluation of growth and thriving in children. Therefore, the WHO growth standards were not implemented automatically. First, the study on growth of Czech infants exclusively or predominantly breastfed for at least 4 months (n=960) was undertaken. The aim of the study was to evaluate whether Czech growth references or WHO growth standards are more appropriate for growth assessment of Czech children. The study monitored four basic body parameters - length, head circumference, weight and weight to length. The hypothesis that growth curves of Czech breastfed infants will correspond to the WHO growth...
|
|
|
Clinical aspects of selected rare diseases in children.
Mazurová, Stella ; Honzík, Tomáš (advisor) ; Hrstková, Hana (referee) ; Votava, Felix (referee)
Introduction: Diagnosing inborn metabolic diseases, as a large subgroup of rare diseases, due to their rarity and wide variety of clinical manifestations, can be demanding and often prolonged. Objective: The aim of this work is, with the regard to clinical, biochemical and genetical aspects of selected rare diseases, to contribute to their rapid detection, widen the features of the natural course of the disease and contribute to their preventability. Material: This work includes cohort studies of patiens with cardiac manifestations in mitochondrial diseases, namely a group of 48 patients with TMEM70 protein deficiency, a group of 4 patients with Barth syndrome and individual cases of rare mitochondrial cardiomyopathies, thimidine kinase 2 deficiency and alanyl tRNA synthetase 2 deficiency. By determining the frequency, severity and type of heart disease, the phenotype was expanded, and the design of a therapeutic algorithm then made a positive impact on the prognosis of these patients. The work is also focused on the role of cardiac disease in the differential diagnosis of other genetically determined rare diseases, Marfan's syndrome and especially Pompe disease, where the emphasis is on early diagnosis, mainly due to the existence of an effective therapy. Focus on a broader differential diagnosis...
|
|
|
Thyroid Gland in Newborn
Krylová, Kateřina ; Bayer, Milan (advisor) ; Al Taji, Eva (referee) ; Hrstková, Hana (referee)
THYROID GLAND IN NEWBORN MUDr. Kateřina Krylová SUMMARY Normal thyroid gland function during pregnancy and in newborns is a basic condition for normal growth, development and neurologic status during childhood and adulthood. The thyroid function can be influenced by external factors (mainly iodine supplementation and maternal thyroid diseases) and by anatomic and functional development of the fetal thyroid gland. Thyroid gland begins to form from third to twelfth gestational week and fetal thyroid hormones are detectable after 12 weeks of gestation. Fetus is fully dependent on maternal thyroid hormones during the first half of pregnancy and on maternal iodine supplementation during the whole course of pregnancy. The Czech Republic is considered a country with sufficient iodine supply in the general population although pregnant women are a population group in risk of iodine deficiency. Maternal thyroid diseases and iodine deficiency can lead to more prominent disability in newborns with congenital hypothyroidism even when treated in time. The functioning screening of congenital hypothyroidism and timely treatment is effective protection of affected newborns. One part of the management of these newborns is causal diagnosis of the congenital hypothyroidism. We are able to distinguish between morphologic...
|
|
|
Growth of the Czech breastfed children at the age of 0-12 months
Riedlová, Jitka ; Schneidrová, Dagmar (advisor) ; Hrstková, Hana (referee) ; Sedlak, Petr (referee)
In the last decade, there is a growing focus of health professionals on growth of children and their mode of feeding in the early age. According to the WHO global public health recommendation, infants should be exclusively breastfed for the first six months and thereafter should receive nutritionally adequate and safe complementary foods while breastfeeding continues up to two years or beyond. In 2006, the WHO published growth standards and recommended their using for the assessment of growth of children up to the age of 5 years. The Czech Republic has a long-term tradition of its own nation-wide anthropological surveys (CAS) which provide data for constructing reference growth charts to be used for evaluation of growth and thriving in children. Therefore, the WHO growth standards were not implemented automatically. First, the study on growth of Czech infants exclusively or predominantly breastfed for at least 4 months (n=960) was undertaken. The aim of the study was to evaluate whether Czech growth references or WHO growth standards are more appropriate for growth assessment of Czech children. The study monitored four basic body parameters - length, head circumference, weight and weight to length. The hypothesis that growth curves of Czech breastfed infants will correspond to the WHO growth...
|
|
|
Acute and chronic airways disease in children: new bioindicators and molecular targets for therapy
Šenkeřík, Marian ; Chládková, Jiřina (advisor) ; Hrstková, Hana (referee) ; Kopřiva, František (referee)
The aim of this thesis was to contribute to the standardization and validation of expiratory flow parameters independent of NO testing, particularly alveolar concentration (CANO) and bronchial NO flux (JawNO) in children and adolescents with allergic respiratory diseases. The thesis was created in the time of increased interest of medicine professionals in non-invasive examination methods and targeted therapeutic influence of inflammation in small airways in asthmatics. After the standardization and validation of clinical benefits, the measurement of concentrations of nitric oxide (FENO) in the air exhaled through the mouth with the speed of 50 ml/s was validated for the evaluation of eosinophilic airway inflammation in patients with asthma and started to be widely used in clinical practice. Currently, there is an ongoing research focused on a new method for FENO measurement at several flow rates, which uses physiological models of NO transfer in exhaled air, allowing to quantify the amount of NO in an indirect way and to monitor the intensity of the inflammatory processes in distal and proximal airways non- invasively. In groups of children and adolescents with allergic rhinitis and / or bronchial asthma and their healthy peers (aged 6 -19 years), the concentration of FENO was examined using online...
|
|
| |
|
| |
|
| |
|
| |
|
| |
guest ::
RSS feed.