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New antimcrobial peptides isolated from the bee venom and the study of their action mechanism
Čujová, Sabína ; Čeřovský, Václav (advisor) ; Fusek, Martin (referee) ; Hlaváček, Jan (referee)
EN The growing emergence of bacteria resistant to conventional antibiotics is very alarming. This has prompted an intensive search for alternative antimicrobial agents which kill bacteria with different modes of action than do traditional antibiotics and do not develop drug resistance. Among these, antimicrobial peptides (AMPs) are considered as promising compounds against resistant pathogens. These positively charged peptides permeabilize or disrupt bacterial cell envelope which leads to leakage of cytoplasmic components and cell death. The aim of my dissertation thesis was the study of the action mechanism of novel antimicrobial peptides which I have isolated from the venom of different wild bees. I identified six novel AMPs which were named panurgines (PNG), codesane (COD) and antapines (ANTPs). These peptides were isolated from the venom of three different bee species (Panurgus calcaratus, Collete daviesanus and Anthophora plumipes). I was also involved in the structural studies of lasiocepsin (Las), the antimicrobial peptide identified in the venom earlier in our laboratory. All studied peptides possess activity against various strains of bacteria and low or moderate hemolytic activity. We prepared series of PNG, COD and ANTP analogs in order to study the effect of physicochemical properties...
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Business processes in a selected company
Michálek, Lukáš ; Hlaváček, Jan (referee) ; Ulč, Jakub (advisor)
The bachelors´s thesis deals with the optimization of business processes in a selected company. The first part describes the theoretical basis for the method of analysis, modeling language and business negotiations. In the second part, analytical, the MMABP method is used for process analysis and qualitative research to obtain data for process optimization. In the third part, proposal, a new proces sis created and solutions are recommended for the company.
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New antimcrobial peptides isolated from the bee venom and the study of their action mechanism
Čujová, Sabína ; Čeřovský, Václav (advisor) ; Fusek, Martin (referee) ; Hlaváček, Jan (referee)
EN The growing emergence of bacteria resistant to conventional antibiotics is very alarming. This has prompted an intensive search for alternative antimicrobial agents which kill bacteria with different modes of action than do traditional antibiotics and do not develop drug resistance. Among these, antimicrobial peptides (AMPs) are considered as promising compounds against resistant pathogens. These positively charged peptides permeabilize or disrupt bacterial cell envelope which leads to leakage of cytoplasmic components and cell death. The aim of my dissertation thesis was the study of the action mechanism of novel antimicrobial peptides which I have isolated from the venom of different wild bees. I identified six novel AMPs which were named panurgines (PNG), codesane (COD) and antapines (ANTPs). These peptides were isolated from the venom of three different bee species (Panurgus calcaratus, Collete daviesanus and Anthophora plumipes). I was also involved in the structural studies of lasiocepsin (Las), the antimicrobial peptide identified in the venom earlier in our laboratory. All studied peptides possess activity against various strains of bacteria and low or moderate hemolytic activity. We prepared series of PNG, COD and ANTP analogs in order to study the effect of physicochemical properties...
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Trust and Environmental Regulations
Hlaváček, Jan ; Geuss, Erik (advisor) ; Macháč, Jan (referee)
This thesis analyzes impact of social trust on environmental regulations stringency. Negative effect is suggested. Thesis documents that, in a cross section of countries, there is no evidence of such an effect. On the other hand, there is evidence of positive impact of GDP per capita and level of education.
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