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In vitro anti-proliferation activity alkaloids the Amaryllidaceae
Panenková, Kristýna ; Havlík, Jaroslav (advisor) ; Jarošová, Veronika (referee)
Summary
Natural phytochemicals are currently used in the treatment of many diseases. Cancers are just ones of them and they are ranked among the most common and the most serious. Phytochemicals in the form of cytostatics are used in chemotherapeutic treatment of cancer. In future there could be included among cytostatics also some alkaloids from the family
of Amaryllidaceae, whose testing for a selective cytostatic effect on tumor cell lines
of colorectal carcinoma Caco-2 and HT-29 and on normal cell lines of human intestinal epithelial FHs 74 Int is a subject of this thesis.
There were tested 17 alkaloids isolated from plants of Chlidanthusfragrans, Zephyranthes robusta and Nerine bowdenii. Particularly alkaloids from plant Zephyranthes robusta namely haemanthamine with this values: IC50 = 0.99 plus/minus 0.14 microM for tumor cells, Caco-2, 0.59 plus/minus 0.01 microM for tumor cells HT-29 and 19.47 plus/minus 8.86 microM for normal cells
FHs 74 Int, Lycorine with values IC50 = 0.99 plus/minus 0.08 microM for tumor cells Caco-2, 1.2 plus/minus 0.01 microM for tumor cells HT-29 and 22.68 plus/minus 0.09 microM for normal cells FHs 74 Int and Haemanthidin with values IC50 = 3.29 plus/minus 0.91 microM to tumor cells Caco-2, 1.72 plus/minus 0.11 microM to tumor cells HT-29, and 11.63 plus/minus 0.86 microM for normal cells FHs 74 Int proved a significant
anti-proliferative activity.
From these results there is evident the selectivity against colorectal cancer cell lines. For this reason, those tested alkaloids are suitable for further testing and for study of their biological activity against tumor cells in the terms of in vitro and in vivo.
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Comparison of school catering policies in the Czech Republic and other european countries
Lídlová, Barbora ; Havlík, Jaroslav (advisor) ; Anna, Anna (referee)
The school lunch provides an important opportunity for learning healthy habits, and well-balanced school meals have been linked to improved concentration in class, better educational outcomes and fewer sick days. School lunches are diverse across Europe. Many countries in Europe have policies to help schools provide nutritionally balanced meals which also reflect the general eating culture of each nation. The most advanced systems of school meals include those in Finland and Sweden, where all school meals are fully funded by the government. In 2014 first children between the ages of five and seven received a free school lunch in The United Kingdom. In England, school meals have increased their level due to the fact that renowned chef Jamie Oliver noticed how poor quality school meals had. The Jamie Oliver Food Foundation was founded in 2002 and run three core food education programmes in schools. Recently, a very interesting topic is organic food in school meals, and less use of convenient food. Italy has become a pioneer in Europe to use organic and local products in school meals. 40 % of their served food has an organic origin. Across France are all vending machines banned from school since 2005. Countries which do not have compulsory system of school catering services are e.g. Norway, Netherlands and Belgium. Czech school meals are one of the best in Europe. And not just in terms of a comprehensive system of school lunches, but also by the availability of full hot school lunches of high quality for all children. School canteens in Czech Republic based their nutrient ration on recommended daily nutrients intake, which provide daily need of essential nutrients and vitamins. These daily intakes are part of Decree 107 of 2005. In these days, in Czech Republic is discussed question of the ban on vending machines. And in February 2015, it has been decreed to ban the sale of unhealthy snacks and beverages in Czech schools approved by the Chamber of Deputies of the Parliament of the Czech Republic.
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COMMERCIALIZATION OF ARTIFICIAL MUSIC
Veselý, Šimon ; MIKOLÁŠEK, Daniel (advisor) ; HAVLÍK, Jaromír (referee)
This bachelor thesis discusses the commercialization of artificial music with special attention to the situation of contemporary music literature for percussion. The aim of thesis is to show the artistic value, which is the main aspect of the recognition of commercial manipulation. The thesis also describes the role of the music industry, technology and mass media due to the popularization of musical works. The work is based on the knowledge of music of the 20th and 21st century art and the concept of recontextualization values during this music period.
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Reicha's conception of the counterpoint in the context of this music theoretical discipline
Havlíček, Vít ; HAVLÍK, Jaromír (advisor) ; Freemanová, Michaela (referee)
The subject of this dissertation is the conception of the counterpoint by Antonín Rejcha. Rejcha was working on his conception systematically all of his life and he defined it in his two treatises: Ueber das neue Fugensystem and in several parts of Traité de haute composition musicale. In this dissertation, i'm focusing on the second treatise. Besides of detailed commentary of Rejcha's thoughts, i'm trying to put them in the context of his predecessors, contemporaries and succesors, by which i'm reflecting importance of Rejcha's ideas in the field of counterpoint.
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SOLO FOR FLUTE IN THE WORKS OF THE CZECH AND SLOVAK COMPOSERS AFTER 1989
Bandúrová, Zuzana ; PIVODA, Radomír (advisor) ; HAVLÍK, Jaromír (referee)
My diploma work "Solo for Flute in the Works of the Czech and Slovak Composers after 1989" is cataloguing works for flute solo, flute with accompanying instrument, flute and electronics, flute and string quartet and flute with orchestra, that were composed after the "velvet" revolution. It includes all available information and to compositions, I was able to perform, or which I consider most important, I provide the interpretation analyses. Annexe of the work contains two interviews with Profesor Vladimír Bokes and Profesor Marek Kopelent, which help to describe the period and creative atmosphere after 1989.
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Company Performance Assessment
Havlík, Jakub ; Smejkal, Martin (referee) ; Veselý, Josef (advisor)
Bachelor’s thesis deals with performance and management evaluation of VAMET Ltd. Comprehensive analysis is made on the basis of assessing, nine criteria model of Quality Council of the Czech Republic, called Start Plus model. Specific survey with point values is made due to help reveal strengths and weaknesses of the company. Supporting measures are proposed towards the end of the thesis, which should contribute to the development of the company’s performance.
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