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National Repository of Grey Literature

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	Nucleosid fosfonové kyseliny a odvozené oligonukleotidy: Strukturní diversita vs biologické vlastnosti Rosenberg, Ivan ; Barvík, I. ; Buděšínský, Miloš ; Kočalka, Petr ; Králíková, Šárka ; Liboska, Radek ; Pačes, Ondřej ; Páv, Ondřej ; Petrová, Magdalena ; Pohl, Radek ; Pressová, Martina ; Rejman, Dominik ; Votruba, Ivan ; Točík, Zdeněk This article deals with the biological and physico-chemical properties of both isopolar, isosteric and non-isosteric phosphonate nucleotides and oligonucleotides. Detailed record
	Oligo-3'-deoxynukleotidy s chirální alfa-hydroxyfosfonátovou 2',5' internukleotidovou vazbou: zlepšení hybridizační selektivity vůči RNA? Králíková, Šárka ; Buděšínský, Miloš ; Liboska, Radek ; Páv, Ondřej ; Rosenberg, Ivan Synthesis and hybridization selectivity of 9-mers 5’-d(GTG ATA TGC)-3’ (T means modified units) containing both hydroxyphosphonate and phosphodiester 2’-5’ internucleotide linkages toward complementary DNA and RNA counterpart were investigated. Detailed record
	Monomery pro nové fosfonátové oligonukleotidy, potenciální inhibitory RNasy L Liboska, Radek ; Páv, Ondřej ; Rosenberg, Ivan Synthetic route for the preparation of 2',3'-O-phosphonoalkylidene , and 3',5'-O-phosphonoalkylidene ribonucleotide monomers for automated oligonucleotide synthesis (a phosphotriester condensation approach) has been developed. Detailed record
	Izopolární, izosterní 4'-substituované 2',5'-oligoadenyláty jako potenciální aktivátory RNasy L Pačes, Ondřej ; Rosenberg, Ivan Synthesis of two different monomers usable for solid phase synthesis of two basic types of phosphonate and phosphodiester 2’,5’-oligoadenylates as potential activators of RNase L is reported. Detailed record
	Syntéza monomerů pro prolinolové oligonukleotidy Vaněk, Václav ; Buděšínský, Miloš ; Rosenberg, Ivan A series of prolinol-based modified nucleotide monomers with phosphonomethyl or phosphonoformyl group attached to the pyrrolidine nitrogen was prepared; the monomers will be used for solid phase synthesis of oligonucleotide analogues. Detailed record
	ABEI-značené 2-5A: Způsob chemiluminiscenčního sledování vazebného procesu RNase L Páv, Ondřej ; Protivínská, Eva ; Jiráček, Jiří ; Rosenberg, Ivan As an alternative for radiolabeled ones, chemiluminescent ABEI-labeled 2-5A probe was synthesized and evaluated for its concentration-dependent detection limit. Detailed record
	From nucleoside phosphonic acids to modified oligonucleotides Rosenberg, Ivan ; Endová, Magdalena ; Králíková, Šárka ; Liboska, Radek ; Rejman, Dominik ; Točík, Zdeněk A number of new isopolar phosphonate nucleotide analogues were prepared and a large set of oligonucleotides containing structurally diverse modification internucleotide linkages could be created. Detailed record
	Isosteric phosphonate mono-and oligonucleotides originating from 4',5'-didehydronucleoside precursors: some synthetic possibilities and limitations Točík, Zdeněk ; Liboska, Radek ; Barvík, I. ; Buděšínský, Miloš ; Masojídková, Milena ; Kavenová, Ivana ; Rosenberg, Ivan The work deals with aspects of synthesis and properties of isosteric phosphonate analogs of 5'-monophosphates and with structure-properties relationship of the related oligothymidylates. Detailed record

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