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The relationship between plasma values of cytokines and insulin resistance during diet-induced weight loss
Polášková, Pavlína ; Štich, Vladimír (advisor)
The theme of my thesis I have chosen with regard to its long-term interest in the field of diabetology and related diseases lifestyle. The increasing prevalence of obesity and diabetes II. typeleads to study their pathogenetic relations. As the prospective in this regard, research shows adipocytokines, ie substancesproduced white adipose tissue. Adipose tissue is growing even after thephysical growth and as one of the largest endocrine organs and adipocytokinesreleased into the circulation can have serious systemic effects. It also appears that obese adipose tissue is in a state of chronic mild inflammation and weight reduction, this inflammatory condition and its complications (mainly CVS) accordingly. Relationship adipocytokines and insulin resistance Thus the development of diabetes II. type with emphasis onchanges in their levels occur during weight loss, is the subject of this work.
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Is the volume of the visceral adipose tissue related to degree of insulin resistance in human
Semerák, David ; Štich, Vladimír (advisor)
The topic of his thesis "The amount of visceral adipose tissue associated the degree of insulin resistance in humans "I chose based on their interest in the issue of obesity and its clinical implications. When thinking I prefer the focus of the topic in some way interfering in the internal medicine, which I have after graduation he wanted to pursue. Although obesity in the Czech Republic is the most common metabolic diseases such as human disease is underestimated, since it usually does not endanger the health obese individuals. Many problems and complications associated with obesity can be prevent early diagnosis and subsequent lifestyle modification, dietary and exercising habits. Therefore I believe that the context described in this work in the future, not only are when preventive action in their medical practice.
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Effect of weight loss on the parameters of metabolic syndrome by obese patients
Hněvkovská, Zuzana ; Štich, Vladimír (advisor)
For the processing of my thesis I chose the topic "Impact of reduction weights on indicators of metabolic syndrome in obese individuals. " It is a broad topic, contains within itself issues weight loss and whole issue of metabolic syndrome X. The reduction in body weight and obesity ever been interested since his high school years, I, on behalf of the metabolic syndrome met to the study of medicine. For a long time I did not know how this syndrome grasp. Where it begins and where it ends? I knew the general obsolete Raevenově definition, also the mysterious names "deadly quartet" or "syndrome X" not corresponding but much of this syndrome. Awareness of the prevalence diseases and complications that patients have. During the study internal medicine, I saw how much it is discussed topic, and how severe the place occupies the field of internal medicine. To choose the topic of his thesis led me Thus, the desire to understand more about the etiology, pathogenetic relationship, complications and treating this syndrome.
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Molecular adaptations of adipose tissue in relation to dietary treatment of obesity in human
Tencerová, Michaela ; Štich, Vladimír (advisor) ; Flachs, Pavel (referee) ; Kazdová, Ludmila (referee) ; Kunešová, Marie (referee)
The general goal of this work was to investigate the molecular adaptations of human AT in relation to DIs with respect to its secretory activity as well as cellular composition focused on macrophages population. Specifically, we studied the role of novel adipokines, such as visfatin and RBP4, related to insulin resistance and AT metabolism. Furthermore, we wanted to characterize the effect of the dietary-induced changes on the content of ATM together with metabolic amelioration. In our studies, we found that lifestyle modifications had a beneficial effect on metabolic and biochemical parameters depending on the duration and type of DI. Regarding both of the investigated adipokines, visfatin and RBP4, we revealed modifications at the transcriptional and cirulating levels during DI. However, we did not find any association with the pattern of evolution of insulin resistance. Our findings do not support a clear hypothesis on the role of these adipokines in the diet-induced improvement of insulin sensitivity and other obesity-related metabolic disturbances. In respect to the changes of ATM content during long-term DI, we demonstrated using flow cytometry that the AT composition was changed at the end of the whole dietary intervention (i.e. after WM phase). This diet-induced AT remodelling was expressed by a...
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Predictors of weight regain after the end of 10-week dietary weight-loss programme (NUGENOB study)
Kukel, Imre ; Štich, Vladimír (advisor)
I would like to thank my consultant, MUDr. Jan Polák for his constructive criticism over my work and his comments for improvements from which I learned much and they were all well appreciated I would like to thank Eva Nemcova, fellow student of the 3rd faculty of Medicine for providing me with the anthropologic data of this study I would like to thank the whole department of Sports Medicine, lead by Doc. MUDr. Vladimír Štich, PhD. for providing me with the resources without which this thesis could not have been made
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The influence of visceral fat mass to utilisation of energetic substrates
Antal, Rudolf ; Štich, Vladimír (advisor)
Obesity is characterized as excess adipose tissue. However, there are Various types of the tissue and the different locations of its presence in the body. visceral adipose tissue is shown as a better indicator for obesity due to complications such as the total amount of fat in the body. The current study followed 62 women who were divided into two groups, and the group of non-obese and obese. Using Computer tomography is measured the amount of visceral adipose tissue along with the total volume body fat. Simultaneously measurements were performed by indirect calorimetry, obtained Data respiratory quotient (RQ) and energy needs-rest (REE) was were processed and analyzed. The aim is to determine the extent to which hits visceral adipose tissue in the oxidation level of the substrate, and has its amount of influence on the utilization of energy substrates
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