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The analysis of pharmacotherapy in patient suffered with dyslipidemia in Greece I.
Mavrovouniotis, Konstantinos - Parmenion ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Social and Clinical Pharmacy The analysis of pharmacotherapy in patients suffering from hyperlipidemia (Diploma Thesis) Mentor of Diploma Thesis Prof. PharmDr. Jiří Vlček, Ph.D. Mavrovouniotis Konstantinos- Parmenion Hradec Králové 2015 ABSTRACT ENGLISH The analysis of pharmacotherapy in patients suffering from hyperlipidemia Mavrovouniotis Konstantinos Mentor: Prof. Dr. Jiří Vlček, CSc. Introduction: Hyperlipidemia is a serious condition whereby the blood levels of lipids, cholesterol and triglycerides are abnormally elevated. This condition is generally asymptomatic but may lead to atherosclerotic heart disease and other types of cardiovascular pathology if not treated effectively. Various risk factors can affect the onset and severity of hyperlipidemia and those include genetic predisposition, hypertension, diabetes mellitus, obesity, poor diet, lack of regular exercise, smoking etc. Measurement and monitoring of blood levels of triglycerides, cholesterol and lipoproteins can be used as prevention method for assessing the risk for an individual to develop hyperlipidemia. Once a patient is diagnosed with the condition several approaches exist for the treatment. The main goal of the treatment is to reduce the risk of...
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Application of explicite criteria of medications potentially inappropriate in the old age in the evaluation of quality of prescribing (III.)
Grešáková, Silvia ; Fialová, Daniela (advisor) ; Zimčíková, Eva (referee)
Introduction: Propotion of older people is rapidly increasing in the world population. Elderly represents a specific, heterogenous population which is because of many reasons more vulnerable to some adverse drug events. Many explicit criteria of potentially inappropriate medication used in the elderly have been developed in order to improve the quality and safety of geriatric pharmacotherapy. These criteria represent basic tools, defining fundamental prescribing rules for the evaluation of appropriate choice and dosing of medications in the old age and for the evaluation of potentially inappropriate prescriptions in older patiens. The aim of the diploma thesis was to compare advantages and disadvantages of explicit criteria published until the end of 2015 year and to summarizea list of allpotentially inappropriate medications in the elderly (regardless of diagnoses and concomitantly used medications), applicable in the epidemiological studies of the EU COST Action 1402project and in subsequent studies. Methods: Using systematic literature search in PubMed dataset, conducted in the period 04/2015 - 12/2015, all explicit and explicit- implicit criteria (published in the foreign peer- reviewed scientific journals bythe end of year 2015 and validated by expert panels) have been identified. Information...
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Patient Perspective of Medication Information Desired
Kalaitzidis, Panagiotis ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
Title: Patient perspective of medication information desired Student: Kalaitzidis Panagiotis Tutor: Jiri Vlcek Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Background: Even from the decade of 1970, patients wanted more information about drugs and did not want to be so depended on the information the physician provided them. Today patients are more than ever informed about their disease and the available and appropriate treatment, due to the high volume of information that can be acquired through the Internet. The traditional role of pharmacists was the provision of medicines to the population. However, nowadays, this role has been changed so as to include other tasks, such as management of prescribed medicines, and promotion of health, since pharmacists can serve as a source of expertise knowledge to the customers. Due to the fact that there is no relevant research for the case of Greek patients, this pilot research could help to fill this gap, by trying to find out what kind of information patients want to know about medicines in several pharmacies in Greece. Aim: The aim of this research is to examine what kind of information patients want related to medicines. More precisely, this research will try to identify the type of...
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Side and teratogenic effects of valproic acid in pregnancy nad in calcium metabolism
Veselá, Kristýna ; Pávek, Petr (advisor) ; Zimčíková, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Sciences Candidate: Kristýna Veselá Supervisor: Doc. PharmDr. Petr Pávek, Ph.D. Title of diploma thesis: Adverse and teratogenic effects of valproic acid in pregnancy and calcium metabolism Valproic acid and sodium valproate (VPA) are substances with a broad spectrum of anticonvulsive effects. The VPA is mainly used in the treatment of bipolar disorder and epilepsy. The combination therapy with other antiepileptic drugs (AEDs) has been established in the treatment of acute mania, when compared with monotherapy. Various molecular mechanisms of action are responsible for the broad spectrum of VPA effects. VPA interpheres with GABA and glutamate brain neurotransmission, as well as affects intracellular mechanisms. Adverse drug reactions affect 10-20% of patients. They are mostly transient and usually resolve spontaneously or after dose reduction of VPA. Most of the VPA adverse effects, such as weight gain, gastrointestinal problems, sedation, hepatotoxicity and others, are dose dependent. The use of VPA in pregnancy and polytherapy is undesirable due to increased risk of congenital defects. It appears that other AED in this regard, potentiate the effect of VPA. The teratogenicity of VPA was...
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Population and Drugs
Feberová, Beata ; Práznovcová, Lenka (advisor) ; Zimčíková, Eva (referee)
POPULATION AND DRUGS Autor: Feberová B., Dept. of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Tutor: Práznovcová L., Dept. of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Background: The cardiovascular prescription has significant role in fight cardiovascular disease, which they are head cause of death in most of industrial advanced countries. Aim of study: The objectiv of the diploma work was find out the cardiovascular prescription, analyse what kind effective matters included with medicinal preparation on the cardiovascular system was prescribe for patients in practice - which dosage and which combinations. Methods: The 150 patients (98 female, 52 male, age 21 and more years), who come in chemist with medical recipe was accidentally chosen. These patients complete list of questions pertain to drugs prescribed by doctor, drug published without prescription, drugs expended without medical recipe, footage behind drugs and medical care. Study was performed in period November - December 2007. Results: Drugs on the cardiovascular system (group C according to ATC classification) generated 48,5 % of the all analysis prescribed by doctor preparations. Mostly persons,...
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Drugs and people III.
Hudcová, Petra ; Zimčíková, Eva (referee) ; Práznovcová, Lenka (advisor)
15. SUMMARY DRUGS AND PEOPLE III. Author: Hudcová Petra (Department of social and clinical pharmacy, Faculty of pharmacy in Hradec Králové, Charles university in Prague) Tutor: PharmDr. Práznovcová Lenka, Ph.D. (Department of social and clinical pharmacy, Faculty of pharmacy in Hradec Králové, Charles university in Prague) Backgroud: Availability of drugs is limited by many factors. Economic factors are one of the most important. The financial participation of patients on drugs is one of basic metod for regulation the costs in health. Increase the financial participation of patients on drugs and reduction stae costs on pharmacotherapy (in cases where it's possible in terms of availability) may be increased the availability of more expensive pharmacotherapy. Aim of study: The aim of the theoretical work is mapping the current situatian in the Czech republic in relation to the price of drugs. Practical part of the work is focused on the evaluation research conducted among pharmacy clients in pharmacy "Koruna" located in West Bohemian town Ostrov. Methods: The survey was conducted through questionnaire "People and drugs". This questionnaire was created on Department of social and clinical pharmacy, Faculty Of Pharmacy in Hradec Králové. Data was obtained from clients pharmacy in term of November - December...
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ANTIBIOTIC CONSUMPTION ANALYSIS BASED ON HEALTH INSURANCE COMPANY DATA
Buriánková, Lenka ; Zimčíková, Eva (referee) ; Vlček, Jiří (advisor)
ANTIBIOTIC CONSUMPTION ANALYSIS BASED ON HEALTH INSURANCE COMPANY DATA Student: Buriankova L. Tutor: Vlcek J., Dept. of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Background: Overuse and misuse of antibiotics leads to increased resistance of microorganisms to antibiotics. There is a risk we will not have antibiotics effective against pathogenic microorganisms in future. It is therefore very important to make guidelines for rational prescribing and use of antibiotics. Aim: Analyze antibiotic consumption data package collected in given period depending on consumer age or sex. Analyze which group of doctor prescribes antibiotics in most cases. Analyze the most prescribed substances depending on different expression of consumption and compare obtained data with available data. Methods: Source of data is a database of employment insurance. The number of insurance clients was 129 699 in 2006 and 131 876 in 2007. Antibiotic use was evaluated, namely the group J01 of ATC system - Antibacterial drugs for systemic use. Data cover years 2006 and 2007. AISLP-CR, version 2008.4 is a database used for searching information about different drugs and substances. Obtained data were summarized in a database in Microsoft Excel. ATC / DDD system was...
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Drugs and people III.
Podhrázská, Blanka ; Práznovcová, Lenka (advisor) ; Zimčíková, Eva (referee)
DRUGS AND PEOPLE III. Author: Podhrázská B., Department of social and clinical pharmacy, the Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech republic Leader: Práznovcová L., Department of social and clinical pharmacy, the Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech republic Introduction: Consumption of drugs is part of the pharmacoeconomics and makes it possible to measure the costs incurred by the state on illness and is an indicator of the necessity of drugs in any state. Aim of thesis: The Aim of thesis was to determine the consuption of the drugs in the Czech republic in the years 2004-2008 using available databases and questionnaires to avaluate how medicines are currently prescribed and used by patients. Method: 150 patiens were selected on random (98 women and 52 men, age 23 and over), who came to the pharmacy with prescription. Patients completed an anonymous questionnaire concerning personal data, prescription drugs, OTC drugs, regulatory fees and supplements. Results: The most of drugs are used in group C - cardiovascular system (43%), A - alimentary system and metabolism ( 11%), N - nervous system(11%) and M - musculosceletal system (10%). Patiens pay for OTC drugs monthly about 100 CZK (61% respondents). Deduction: Consumption of...
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