|
|
Determination of the plasticity of mannitol
Šulková, Petra ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Šulková Petra - Rigorózní práce - 2006 This work deals with the evaluation of plasticity of mannitol by means of the stress relaxation method. Theoretical part of the work describes preparation of the tablets by direct compression, theory of compression and characterizes mannitol. The aim of the work was the determination of mannitol plasticity, following of the influence of the dwell time on residual plasticity and determination of the dependence of residual plasticity on compression force. The plasticity was measured by means of T1 - FPO 50 device. It follows from the results of the work that the increase in dwell time of mannitol tablets lead to the increase of plasticity. Mannitol had the parameter A 56.62 % and B -0.369% kN-1 .
|
|
| |
|
|
Determination of the crushing process parameters for tablets with acetylsalicylic acid
Gallová, Zuzana ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Gallová Zuzana - Rigorózní práce - 2006 This work deals with the determination of parameters of destructive process for tablets containing acetylsalicylic acid. Dry filler microcrystalline cellulose is characterized in the theoretical part. Mechanical properties are also evaluated and theory of tablet destruction is described. The aim of the work was the determination of an optimal cycle rate and height of preloading. The determination was carried out with Acylpyrine using T1 - FRO 50 device. It follows from the results of the work that the suitable setting for measurement of mechanical resistance by means of T1 - FRO 50 instrument is cycle rate 0.6 mm/s and preloading 0.1 N.
|
|
|
Calorimetric evaluation of compatibility between the components of the mixtures for tableting
Kopecká, Milada ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Kopecká Milada - Rigorózní práce - 2006 This work deals with the compatibility of a medical substance with 15 additives using the DSC method. Theoretical part of the work describes thermoanalytical methods, methods of thermal analysis, calorimetric methods and differential scanning calorimetry. Besides the work deals with the crystalline structure of solid compounds. The aim of experimental part of the work was the calorimetric evaluation of the medical substance itself, all additives and mixtures of medical substance with additives. The compatibility was measured by means of DSC 200 PC Netzsch. The result of the work was to prove the compatibility of the medical substance with lactose, Kopovidone, Povidone 25, silica, mannitol, Emcompress, magnesium stearate, and calcium stearate. Incompatibility was found out between the medical substance and glycerol behenate.
|
|
|
Deformation index for tablets of microcrystalline cellulose
Myslivečková, Jana ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Myslivečková Jana - Rigorózní práce - 2006 This work deals with deformation index of tablets of microcrystalline cellulose. Theoretical part describes the theory of tablet formation by means of the record force - displacement. It also characterizes microcrystalline celluloses. The aim of the work was to find out the influence of a filler on the parameter E2 of the compression process and on the parameter DE of the destruction process. Further to asses the influence of the relation between parameters DE, D and E2,DE and effect of the filler type on new parameter DI. Six various fillers were tested. Ceolus KG 802 Avicel PH 102, Avicel PH 200, Pearlitol 100 SD, Tablettose 70, and Emcompress. The results show that polymeric microcrystalline celluloses accumulate less energy at compression than crystalline compounds. However, they have higher value of D. Microcrystalline celluloses have the highest values of the parameter DI. A semilogarithmic dependence was found between the parameters D and DE.
|
|
|
Influence of compressing speed and time of constant load on the energy balance of tablets
Císařová, Daniela ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Císařová Dana - Rigorózní práce - 2006 This work deals with the influence of the compression rate and time of constant load on energy balance of tablets. Theoretical part characterizes microcrystalline celluloses, describes theory of tableting and theory of the force - displacement record. The aim of the work was to find out the influence cycle rate on the force Fmax , influence of the cycle rate and dwell time on parameters of energy balance, influence of the cycle rate on mechanical resistance of tablets. The determination was carried out with tablets of microcrystalline cellulose Avicel PH 200 using T1 - FRO 50 device. It follows from the results that the higher the cycles rate the higher values of parameters Emax and E1-3. Dwell time does not influence above-mentioned parameters. Radial strength des not change with the increase of cycle rate from 0.1 to 2 mm/s. Further increase in cycle rate brings about higher strength of tablets. Optimal cycle rate is 1 mm/s.
|
|
|
Energy balance of crushing tablets
Čámský, Václav ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Čámský Václav - Rigorózní práce - 2006 This work deals with energy balance of tablet destruction. The characterization of individual groups of tablets and characterization of two fillers - lactose and microcrystalline cellulose- for direct compression is mentioned in the theoretical part. The aim of the work is to find out the influence of the type of a dry filler on the punch displacement and to describe the dependence between the parameter of the compression process E2 and parameter of the destructive process DE. The determination was carried out with the tablets of Avicel PH 102, Flowlac 100 and lactose anhydride using T1 - FRO 50 device. It follows from the results that destruction displacement of microcrystalline cellulose is substantially longer than in the case of lactoses. Microcrystalline cellulose compared to lactoses consumes significantly less amount of energy. The cycle rate 0.1 mm/s was used for measurement of mechanical resistance.
|
|
|
Deformation index for tablets of lactose and mannitol
Neckářová, Kamila ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Neckářová Kamila - Rigorózní práce - 2006 This work deals with deformation index of tablets of microcrystalline cellulose, mannitol and lactose. The aim of the work was to find out the effect of filler on parameters DE and E2.The new parameter DI, deformation index, was studied as well,. It expresses the ratio between DE and E2. The measurement was carried out by means of T1 - FRO 50 device. The results show that the highest amount of energy was accumulated by mannitol, less by lactose and lowest amount by microcrystalline cellulose. The anhydride form lactose and mannitol has the parameter D lower than monohydrates. A semilogarithmic dependence was found between parameters D and DE. New parameter DI reaches highest value for microcrystalline cellulose, lower for mannitol and lowest for lactose.
|
|
|
A study of the properties of tablets from coprocessed dry binder based on directly compressible starch and lactose.
Moučková, Eva ; Mužíková, Jitka (advisor) ; Řehula, Milan (referee)
The paper deals with the study of the properties of tablets from coprocessed dry binder StarLac. The properties under study included the tensile strength and disintegration time in dependence on compression force, addition of two lubricants (magnesii stearas, sodium stearylfumarate) in two concentrations (0,4. 0,8%) and a 50% addition of the active ingredient ascorbic acid. The compression forces were 15, 16, 17 kN, in the case of the tableting material with the active ingredient only 16 kN. The addition of magnesii stearas in a concentration of 0,4% increased the tensile strength, but in a concentration of 0,8% didn't. The same result is in the case of sodium stearyl fumarate for compression force 17 kN. The addition of lubricants increased the disintegration time of tablets, less in the case of Pruv. The addition of ascorbic acid decreased the tensile strength of tablets, the disintegration time was shorten. StarLac without and with magnesii stearas too offers the tablets with higher tensile strength and with shorter disintegration time then the physical mixture of Starch 1500 and Pharmatose DCL 15.
|
|
|
Characterization of lactose by differential scanning calorimetry
Stoklasová, Markéta ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Stoklasová Markéna - Rigorózní práce - 2006 This work deals with the characterization of lactose by differential scanning method. Theoretical part characterizes lactose and describes the method of differential scanning calorimetry. This chapter also mentions the factors effecting DSC thermograms. The aim of the work was to carry out calorimetric evaluation of beta lactose, D lactose, and alfa lactose. The calorimetric measurements were realized by means of DSC calorimeter DSC 200 PC Netzsch. The results of the work list melting temperatures and values of Tg of lactoses studied. The results are compared with the values of lactose used as filler for tablet production.
|
guest ::
