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Levels of specific antibodies against measles, in university hospital staff, during the 2018-2019 measles outbreak in Prague, CZ
Malinová, Jana ; Čelko, Alexander (advisor) ; Částková, Jitka (referee) ; Göpfertová, Dana (referee)
Levels of specific antibodies against measles, in university hospital staff, during the 2018-2019 measles outbreak in Prague, CZ. MUDr. Jana Malinová Between May 2018 and December 2019, during an epidemic measles outbreak in the Czech Republic, especially in Prague, a prospective serological study was conducted by staff at the Kralovske University Hospital, which focused on determining the measles seropositivity of the Kralovske University Hospital personal. During the study, a total of 2,782 university hospital employees, between the ages of 19-89 years, were examined. The aim of the study was to determine whether the measles seropositivity rate in health care staff was greater than 90 % and whether seropositivity was affected by any of the studied variables such as gender, age, natural vs. acquired immunity, overweight or obesity, smoking, and concomitant disease. Since childhood immunity, obtained either by infection or vaccination, was assumed, seropositivity persistence into adulthood was also evaluated. The results of the study confirmed that the seropositivity of medical personnel was greater than 90 % independently of how it was acquired. However, seropositivity was higher (98 %) in those who had natural immunity via a childhood measles infection. Although vaccination with at least one dose of the...
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Epidemiological research methods in cardiovascular diseases
Špecián, Miroslav ; Auzký, Ondřej (advisor) ; Čelko, Alexander (referee)
This bachelor paper focuses on the epidemiological methods in the research of cardiovascular diseases. Using 3 cardiovascular diagnosis (acute myocardial infarction, heart arrest and atherosclerosis) as a background, it illustrates individual research designs (types of studies), namely: case report, case series, case-control study, cross-sectional study, cohort study, randomized (controlled) trial and systematic review/metaanalysis. Each of these designs is illustrated by the specific example of a previously performed study. The paper also observes the features distinguishing epidemiological and clinical approaches to medicine and discusses the relation between epidemiology and evidence base medicine (EBM).
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Positive and negative effects of hormonal contraception
Čeřovská, Jitka ; Čelko, Alexander (advisor) ; Dáňová, Jana (referee)
This bachelor thesis deals with serious and very hot topic of hormonal contraception. Besides the history, current trends and methods of contraception focuses on the negative and positive effects on women's health. The particular emphasis is put on the issues of thromboembolic disease, breast cancer and environmental impact by synthetic estrogens. Among the positive effects there dominate reduction of the number of abortions, prevention of ovarian and endometrial cancer and positive effect on polycystic ovary syndrome and osteoporosis. The aim was to show that the positive effects on women's health prevails and the number of abortions has significantly decreased because of the development of the hormonal contraception. key words: hormonal contraception, abortion, positive effects, negative effects, cancer, prevention, methods Powered by TCPDF (www.tcpdf.org)
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