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Passive rehabilitation affecting on spasticity of multiplex sclerosis
Prášil, Jakub ; Bunc, Václav (advisor) ; Foubíková, Bohdana (referee)
Title: The influence of a passive rehabilitation on spasticity in multiple sclerosis Objectives: The main objective is to summarize the current knowledge about multiple sclerosis and the possibilities of influencing the spasticity as a serious symptom. Another objective is to verify the effectiveness of the antispastic passive rehabilitation of the lower limbs of selected patient in practice. Methods: Verification of the effectiveness of the system of antispastic passive rehabilitation of the lower limbs was through a qualitative research. For the work design is used the type of qualitative experiment. The research sample is a person with spasticity in the lower limbs. In the first two parts of the work was used an analysis of scientific literature and a content analysis. The strategy of data obtaining is also in the form of observation, interviewing, measuring, scale and variety. A medical documentation, anamnesis, casuistry and a secondary analysis were used. Results: Individual use of each method resulted in the influence of spasticity only for a short time. Mobility was affected in the sense of passive movement the most after the soft techniques and massage therapy. The most striking results were achieved after the use of all methods when the spasticity was positively influenced in accordance...
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Regulation of Cathepsin D Activity and Activation
Máša, Martin ; Mareš, Michael (advisor) ; Jonáková, Věra (referee) ; Holada, Karel (referee)
PhD Thesis ABSTRACT REGULATION OF CATHEPSIN D ACTIVITY AND ACTIVATION Martin Máša supervisor: Michael Mareš Department of Biochemistry Faculty of Science Charles University Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic PRAGUE 2009 Introduction Cathepsin D (CD) is an aspartic peptidase located in the lysosomes of all mammalian cells, its main role is catabolic degradation of proteins. More over CD is known to participate in a range of physiological processes such as apoptosis and tissue homeostasis, as well as in the regulation of angiogenesis and the production of peptidic antigens. The role of CD in pathophysiology is associated with several diseases such as Alzheimer's disease and cancer. Alzheimer's disease is a neurodegenerative disorder, which is generally considered to be the most common form of dementia. Progression of this disease is accompanied with the deposition of amyloid plaques (AP) in the brain, which leads to neurodegeneration. The AP is a fragment released from amyloid precursor protein (APP) cleaved by secretases1 . High levels of CD were found in cerebrospinal fluid of the Alzheimer's patients2 . It was demonstrated that CD is able to cleave APP and produce the pathogenic AP. A genetic polymorphism in the CD gene was reported, which changes...
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Measuring efficiency of hospitals in the Czech Republic
Procházková, Jana ; Chalupka, Radovan (referee) ; Gregor, Martin (advisor)
This thesis estimates cost efficiency of 99 general hospitals in the Czech Republic during 2001-2008 using Data Envelopment Analysis and Stochastic Frontier Analysis. It tests comparability of their results finding out a certain qualitative similarity. Next, determinants were added into SFA and efficiency of Czech hospitals examined. The presence of inefficiency is group specific even having accounted for various determinants. The effects of determinants were tested. Inefficiency increases with teaching status, more than 20,000 treated patients a year, not-for-profit status, larger share of the elderly in the municipality and average salary in the district. Inefficiency decreases with less than 10,000 patients treated a year, larger population, higher unemployment rate and more hospitals in the region.
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Mental Neglect Hazard Factors of Children Who Live in Their Own Families
RŮŽIČKOVÁ, Martina
The thesis deals with the family in the context of children's psychical neglect, especially with the risk parents and risk children as the main hazard factors. In the end of the theoretical part are defined long term risk situations as one of the possible hazard factors of psychical neglect. The practical part contents results of fully oficial document's analysis worked out by the Children Protection Social-Legal Section of Social Affairs Department of Municipal Office in Prachatice. As the hazard factors of psychical neglect, prematureness, cephalonia and minimal brain dysfunction occur in children registered on file of the Social Affairs Department. Especially emotional deprivation of mothers and mental allienation of fathers were detected in their parents as the main hazard factors. In addition it were one parent's alcoholism and a lack of time for children of the mother. The majority of these children likewise is mentally and physically abused.
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Observation of non invasive and invasive screening cerebral vessels from the radiologic assistants view.
NOVOTNÁ, Dana
The subject my thesis was ? Observation of non invasive and invasive screening cerebral vessels from the radiologic assistants view". In the theoretical parts I explore the disorder of blood - vessel in cerebral occurrence (CMP) and its diagnosis. It is about the acute illness caused by closure of some of the cerebral arteries and resulting in vapidity brain (ischemic) or bleeding to the brain (haemorrhage). It ranks among the most frequent causes death in developed countries. The practical part includes research of usage non invasive and invasive depict methods in brain and cerebral vessels diagnostics. I processed quantitatively the statistical data which I gained from the Radio-diagnostic Ward in hospital in Ceske Budejovice. The result of this emerges from superiority of non-invasive screening above invasive one. In the non- invasive depict methods in diagnosis of CMP most often uses computation tomography (68 %), which for a certainty will distinguish ischemic from haemorrhage. Magnetic resonance (7 %) is more sensitive method at ischemic diagnostics. Another method is the ultra-sonography (13 %), in which we can assess the level of stenos/occlusion screened vessel. As the only vice invasive methods is catetrizac angiography (12 %), which is considered as the golden standard in displaying the blood - vessel bed. Its advantage is the possibility to join endovascular intervention. The next aim was to compare the role of radiologic assistant during single screening. It was necessary to find common point in practical activities of the radiologic assistant at both types o screening and to show the differences in specific substance and the work demands.
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