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Clinical Application of Lung Function Testing in Children
Bašek, Pavel ; Kokštein, Zdeněk (advisor) ; Kopřiva, František (referee) ; Pohunek, Petr (referee)
SUMMARY: In my thesis I have been able to show important results from the clinical application of lung function testing in young children. Following children with congenital diaphragmatic hernia, we have shown that many survivors of CDH have significant respiratory problems. However, the continual growth of airways and lung corrects the initial pulmonary function deficit. In our study, we reported on exhaled nitric oxide in CDH survivors and found normal, non-elevated levels. Studying children with inflammatory bowel disease, unlike as a single published study in adults, we found elevated exhaled nitric oxide also in children with non-active inflammatory bowel disease. The fact that conventional analysis of spirometric parameters failed in predicting the course of asthma has motivated our group to next study. It was an intriguing observation, that the subjective analysis of clinical severity of obstructive lung disease can be correlated to the measurement of curvature by using a mathematical equation. Nitric oxide is an important mediator of inflammation in several pathological conditions and the tendency to measure exhaled nitric oxide under different conditions has reached the neonatal medicine also. The multiple- breath method allows sampling of exhaled air via side stream during tidal breathing in...
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Epidermal growth factor receptor as a predictor of tumor response to preoperative chemoradiation in locally advanced gastric carcinoma
Sirák, Igor ; Petera, Jiří (advisor) ; Šlampa, Pavel (referee) ; Soumarová, Renata (referee)
The purpose of my doctoral thesis was a retrospective evaluation whether the intensity of epidermal growth factor receptor (EGFR) expression in tumor biopsy predicts tumor response to preoperative chemoradiotherapy in patients with locally advanced gastric carcinoma. Thirty-six patients with gastric adenocarcinoma in clinical T2-4 stage and/or with nodal metastases were studied. Preoperative treatment consisted of 30-45 Gy of gastric irradiation with continuous 5-fluorouracil and weekly cisplatin. Surgical resection was performed 4-6 weeks later. EGFR expression in pretreatment tumor biopsies was assessed by immunohistochemistry. Level of EGFR expression was determined from the intensity and extent of staining. Tumor response after chemoradiotherapy was defined as a reduction of at least one T-stage level and/or finding of intense tumor regression in histopathologic examination. Seventeen patients responded to preoperative chemoradiation - 8 patients (22%) had pathologic complete response, 9 patients (25%) were downstaged. Positive EGFR expression was found in 8 tumors (22%), and represented a significant predictive marker of poor tumor response in multivariate logistic regression analysis (p = 0.015). Response to chemoradiotherapy was found in 57% (16/28) of EGFR negative patients and in 13% (1/8)...
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Measuring performance of financial institutions
Pohanka, Eduard ; Křížek, Tomáš (advisor)
The bachelor's thesis is focused on term performance and possibilities of its specification in banking. Terms profitability and efficiency are differed and described as well as possible mothods of their valuation. Basic concepts and indicators of profitability and efficiency are mentioned more closely and ilustrated on concrete values. These methods are judged in terms of simplicity of practical use, predictability and possibilities of interbank comparsion.
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Financial analysis Crystalex, a.s.
Matušková, Petra ; Synek, Miloslav (advisor) ; Lejsková, Linda (referee)
The Financial analysis Crystalex a.s. examines a general financial situation of the company. I use classical methods for financial analysis. The significant part of my project is the application of creditworthy and bankruptcy models. The aim of my thesis is to find out if these models were able to predict the current situation for management in the past.
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Market of analytical CRMs and its development
Zrcek, Milan ; Matuštík, Ondřej (advisor) ; Brixí, Radim (referee)
The aim of this project in first phase is to define the term "analytical CRM" and to define its position in whole CRM. From that results some levels whereas as main is considered the analytical level. For next parts the analysis of up to now CRM market development is fundamental. On the basis of those knowledges is defined recent situation on CRM market. Mainly concrete applications used for analytical purposes and their functionality are meaned by that. Last part is effort to predict future development on analytical CRM market. Whole prediction is based on previous parts of the project.
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Leasing products and car insurance
Matějka, Václav ; Ducháčková, Eva (advisor)
The subject of the diploma paper is to describe the general characteristics of the leasing and insurance products, which are connected with the car financing on the czech market. No less important point is legislative adjustment of mentioned products from the accounting and tax point of view from the livery's and leaseholder's side. Application of the car insurance in particular cases and the integration to the part-payment calendar is the subject of practical part of the paper, which aim is to demonstrate on the concrete example the composition of the part-payment calendar using way outs from the theoretical part. The conclusion of the paper is dedicated to the summary and to the prediction of the future progress on the leasing field.
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Applications credibility and bankruptcy models to compare the financial health of breweries
Varkalová, Světlana ; Holečková, Jaroslava (advisor) ; Staňková, Anna (referee)
This thesis deals with selected credit scoring and bankruptcy models and their ability to pre-dict financial problems in a company. Among the models included in the paper are the Altman bankruptcy model Z - Score, Index of credibility of the Neumaier (IN95, IN05) Taffler mod-el, Kralicek Quick test, Grünwald creditworthiness model. The methodological part focuses on the detailed description of each individual model. The practical part includes a customised application of the models on the selected breweries and subsequent assessment of the ability of the models to predict financial distress.
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Radical view of subjectivism according to L. M. Lachmann and its implications for consumer theory
Panáčková, Eliška ; Špecián, Petr (advisor) ; Máslo, Lukáš (referee)
This Bachelor Degree Thesis is concerned with methodological approach of the radical subjectivist economist Ludwig M. Lachmann and application of his approach on consumer theory. The aim of this study is to evaluate whether is methodological approach of Lachmann compatible with the approach used in mainstream consumer theory, eventually how these approaches are different. The first part deals with the context of radical subjectivism, its pivotal points and the general differences in methodology of Lachmann and mainstream. Then I devote the work of Alfred Schutz, George L. S. Shackle and Max Weber, on the basis of which Lachmann reached the radical approach. In the practical part I apply radical subjectivism on the consumer theory and according to these result I evaluate these approaches are not compatible. Arguments of radical approach is not supported by strong evidence, and this approach is incapable of giving prediction more quality alternative of consumer theory.
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