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Mechanical pretanning in sewage works
Černý, Marian ; Grosman, Martin (referee) ; Němec, Zdeněk (advisor)
The bachelor thesis contains a literature search dealing with mechanical equipment of waste water treatment plants. After introduction of waste treatment there is stated some description of technical and construction search of particular equipment, system of their operating, analysis of their operation parameters and their using on waste water treatment plants in this bachelor thesis. There are described typical ordering of particular equipment in to technological lines on waste water treatment plants. The bachelor thesis contains description of self-cleaning screen, hand skimmed screen, mechanical coarse screen, mechanical fine screen, equipment for grit and sand removing, skimmed cylinder strainers, screw conveyors, screw presses for screenings with washing and integrated coarse pre-treatment. There are published some schemes, sketches, photos and tables of technical parameters above mentioned equipment in this bachelor thesis. The sketches of technical drawing character are treated in Autodesk ACAD 2005 program.
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Leasing according to IFRS
Vosika, Jiří ; Krupová, Lenka (advisor) ; Roubíčková, Jaroslava (referee)
The main theme of this thesis is the isue of leases and its treatment in International Financial Reporting Standards. The thesis is devided into five parts. The first part is devoted to basic characteristics of the lease, its structure and historical development. The third part focuses on convergence of IFRS and US GAAP in leases. This section contains a summary of the opinions contained in Discussion Paper and decisions made at meetings of the IASB and the FASB after publishing of Discussion Paper. The fourth part deals with practical application of the rules contained in IAS 17 at real lease contract. The last part is devoted to research of implementation of disclosure requirements specified in IAS 17.
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Clinical and genetic predictors of drug dependency in inflammatory bowel disease
Ďuricová, Dana ; Lukáš, Milan (advisor) ; Keil, Radan (referee) ; Špičák, Julius (referee)
IN ENGLISH Drug dependency in inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC), is a specific disease phenotype which determines disease prognosis and hence may be used as a prognostic marker for treatment management. Drug dependency in IBD has been well described in corticosteroid treatment and recently also in infliximab (IFX) therapy. The aims of this thesis were: 1) to assess the occurrence of IFX dependency in paediatric and adult patients with CD; further to search for clinical and genetic predictors of IFX outcome and to evaluate the impact of IFX dependency on surgical rate; 2) to assess in CD patients the outcome of the first course of 5-ASA monotherapy with emphasis on 5-ASA dependency and to define clinical predictors of 5-ASA treatment outcome. We found that 66% of children and 29% of adults with CD became IFX dependent. The high frequency in paediatrics is in agreement with previously published studies, while the finding in adult patients indicates a lower rate of IFX dependency in the only study to date. Perianal disease and no bowel surgery prior to IFX start were predicative of IFX dependency in paediatric patients. In adult cohort, 2 genetic variants LTA c.207 A>G and CASP9 c.93 C>T were associated with IFX outcome, whereas no relevant clinical...
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Biological therapy of asthma
Jirásková, Petra ; Pourová, Jana (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Petra Jirásková Supervisor: PharmDr. Jana Pourová, Ph.D. Title of diploma thesis: BIOLOGICAL THERAPY OF ASTHMA This thesis provides an overview of approaches to biological treatment of asthma. The first part deals with a brief description of the disease, and further gives basic information on the preparation of monoclonal antibodies, their structure and mechanisms of action. The second part of this work is focused on biological treatment. Biologics are divided into groups according to their target structures. In each of them, basic features of the most important drugs applied in this indication as well as the results obtained are summarized. Collecting and comparing literature data has been the basic method of work. Foreign- -language medical and pharmaceutical articles published by periodicals and various clinical studies have been the most important sources.
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Inflammation and peripheral metabolism of glucocorticoids
Leden, Pavel ; Kment, Milan (advisor) ; Hampl, Richard (referee) ; Kršek, Michal (referee)
10 Abstract Glucocorticoids play an important role in regulation of inflammation and their immunosuppressive effect is widely used for treatment of inflammatory diseases. The biological activity of glucocorticoids depends not only on their plasma concentrations, the number of receptors and the responsiveness of the target cells but also on the local metabolism of glucocorticoids that is predominated by 11β-hydroxysteroid dehydrogenase (11HSD). Two isoforms of 11HSD are known. The isoform 11HSD1 operates in vivo predominantly as a reductase that increases the local concentrations of glucocorticoids by reduction of their 11-oxo derivatives. The isoform 11HSD2 is a pure dehydrogenase that inactivates biologically active glucocorticoids to their inactive 11-oxo derivatives. The published data concerning peripheral metabolism of glucocorticoids during inflammation were obtained mostly in in-vitro studies. The aim of the thesis therefore was: (1) to study peripheral metabolism of glucocorticoids during trinitrobenzensulfonic acid (TNBS) induced colitis in rat. (2) to study peripheral metabolism of glucocorticoids in biopsies from human ulcerative colitis (3) to examine peripheral metabolism of glucocorticoids during dextran sodium sulphate (DSS) induced colitis in rat and (4) to study peripheral metabolism of...
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Augustin Navrátil and his disident activities
Kordíková, Marta ; Hlavačka, Milan (advisor) ; Randák, Jan (referee)
Augustin Navrátil This thesis addresses the life and work of Augustin Navrátil (1928-2003), a Roman- -Catholic activist from the Moravian township of Lutopecny near Kroměříž. A. Navrátil has not been subject of a complex publication yet, although he is the author of the largest petition demanding religious - and with that going hand in hand also civic - liberties in socialist Czechoslovakia (1988, 600 000 signatures). Followingly, this is the first attempt to biographically outline the personality and motivations of this farmer, politician (member of the party Lidova strana), man who signed Charta 77 but also a husband and father of nine children. The aim is to cover his life from his birth, over his family background to the beginnings and heights of his social engagement. The text will mainly deal with 22 open letters in which he drew attention to various illegal practices and actions of the Communist power, as well as with the three petitions he authored (1978, 1985 a 1988) and the samizdat (self-published) journal Křesťanské obzory (Christian horizons), which he published with a group of others from June 1988 to July 1990. In contrast to most Czech dissidents, he was never sentenced to a prison term for his activities, but he had to involuntarily undergo repeated psychiatric treatment. He was...
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Infectious diseases of chamois, occurance and results of their control in region Jeseníky, Czech Republic
Staňková, Kristýna ; Lamka, Jiří (advisor) ; Ducháček, Lubomír (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Farmacology and toxicology Candidate: Kristýna Staňková Supervisor: Prof. RNDr. Jiří Lamka, CSc. Title of diploma thesis: Infectious diseases of chamois, occurance and results of their control in region Jeseníky, Czech Republic The aim of this study was to compile knowledge of the chamois disease from around the world into a single pack, thereby the issue becomes clearer for further use in the study and treatment. In the Czech Republic still missing such integrated research. Articles published in literature, journals and web sites became the base of this study. A special attention has been paid for chamois population living in Czech Republic with dominating parasitic disease issues. Keywords: chamois - parasite - disease - drug
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Metabolic study of sibutramine
Link, Marek ; Wsól, Vladimír (advisor) ; Holčapek, Michal (referee) ; Nobilis, Milan (referee)
Obesity represents a serious problem especially in American and European populations. Pharmacotherapy in combination with a reduced calorie diet is recommended for obese patients as a multi-modal approach to weight loss. Sibutramine hydrochloride monohydrate represents one of the few established and well-proven agents available for treatment of obesity. It is sold as a racemic mixture under the trade-name Meridia, Reductil or Lindaxa. It acts as a monoamine reuptake inhibitor. The weight loss of patients induced by sibutramine is thought to be due to a combination of serotonin- and noradrenaline-mediated mechanisms that increase both satiety and energy expenditure. In organisms, sibutramine is rapidly demethylated to form metabolites M1 and M2. These metabolites contribute largely to the pharmacological effects of sibutramine and the pharmacokinetic characteristics of M1 and M2 were thoroughly studied in human plasma. Although sibutramine is widely used for the treatment of obesity almost ten years, the published information on the further metabolic fate of metabolites M1 and M2 as well as on the elimination of sibutramine from the body is almost exclusively limited to package inserts of the product. To address this issue we determined the routes of elimination of sibutramine in humans via urine. LC-API/MS...
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Refractive lens exchange and glaucoma prevention
Smržová, Tereza ; Němcová, Iveta (advisor)
The objectives of this thesis were: You summarize and clarify the existing development and potential implantation of intraocular lenses with an emphasis on the use of multifocal intraocular lenses in patients with refractive defects, You collect data on intraocular pressure measured in the preoperative and postoperative examination in patients with implanted multifocal intraocular lenses You evaluate and compare the results of postoperativeexaminations with the results acquired in the preoperative examination focus on the size of intraocular pressure, depending on implantation of multifocal intraocular lenses You evaluate the importance of preventing an increase inintraocular pressure in the treatment of refractive errors and cataracts using multifocal intraocular lenses in patients You compare the results obtained from own studies have published studies in the Czech Republic and abroad.
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Synthesis of Pyrazine Derivates as Potential Antituberculotics I.
Eibinová, Drahomíra ; Opletalová, Veronika (referee) ; Doležal, Martin (advisor)
Theme of diploma thesis: Synthesis of Pyrazine Derivates as Potential Antituberculotics I. My diploma thesis comprises recherché concerned with contemporary importance of tuberculosis and new treatment approaches in its therapy. We have found out the methods of synthesis of amides of pyrazinecarboxylic acid derivates in chemical literature. Experimental part deal with synthesis of six new amides on the basis of pyrazinecarboxylic acid derivates, till now not published. Newly synthesized compounds have been characterized by melting points, TLC, elemental analysis, IR, 1 H and 13 C NMR spectra. In vitro data of eight new compounds are presented. My diplomat thesis brings new antimycobacterial data, antifungal data and log P values are calculated. Hradec Králové, 2010 Drahomíra Eibinová
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