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Range load in the casualty department
SEMECKÁ, Barbora
This bachelor´s thesis looks at the range load in the casualty department. The nursing care is focused on working with people, especially with the sick and is highly demanding, both physically and mentally. When working as a nurse, it is required to be professional and also have the ability of dealing with the unexpected and difficult situations. The knowledge of nursing care and the specific care in the injury area are also very important aspects. Nurses hold a position of responsibility and other people rely on them, they have to be responsible and accountable for their own decisions and actions as well as the results of their work have to be flawless. Another very important point is the mutual collaboration between nurses and local doctors, because just with the mutual help effective and quality care can be achieved.Two aims have been established in this thesis. The first aim: To map out the range of the nursing load in the casualty department. The second aim: To find out if nurses feel more physical or mental stress. Two research questions have been posed. The first research question: What is the nursing load in the casualty department? The second research question: Do nurses in the casualty department perceive more the physical or mental load? The practical part of this bachelor thesis involves the result of the qualitative research investigation. The results have been obtained through a semi-structured interview, which had been realized with the help of nurses who work in the casualty department in the South Bohemian region. In total twelve nurses have been spoken to. All the informations was completely anonymous and all of the respondents had the chance to reject being part of this interview. This interview, which has been made in advance, contained 21 questions in general. The basic identification date have been abducted at the beginning.
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Biologically active metabolites of plants. 3. Alkaloids from Chelidonium majus L. and their inhibiting activity to acetycholinesterase.
Šebestová, Lenka ; Siatka, Tomáš (referee) ; Cahlíková, Lucie (advisor)
Šebestová L.: Biologically active metabolites of plants. 3. Alkaloids from Chelidonium majus L. and their inhibiting activity to acetylcholinesterase. Diploma thesis, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany and Ecology, Hradec Králové 2010, 68 p. The thesis aims to process the shake-out of benzophenanthridine alkaloids, of Chelidonium majus, to isolate at least one alkaloid in pure form; consequently the thesis aims to give exact figures for the anti-cholinesterase, anti-protozoal a antioxidant activity of the alkaloid. The method of column chromatography was used to isolate the two alkaloids of the shake-out. The isolated substances were labelled LŠ1 and LŠ2 respectively. The identification of the substances as stylopine.and chelidonine respectively, was based on NMR and MS studies. Both isolated alkaloids were subjected to inhibition study with respect to human erytrocytal acetylcholinesterase and human seral butyrylcholinesterase. Stylopin showed the following set of results: IC50 (AChE) = 114 ± 2.9 µM, IC50 (BuChE) = >1000 µM. The results being considerably higher in comparison with the standard used, no further usage for the treatment of Alzheimer's disease is expected. Chelidonine showed the following set of results: IC50 (AChE)...
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Biologically active metabolites of plants. 2. Alkaloids from Chelidonium majus L. and their inhibiting activity to acetycholinesterase.
Novotná, Magdalena ; Cahlíková, Lucie (advisor) ; Opletal, Lubomír (referee)
Novotná M.: Biological Aktive Plant Metabolites 2. Alkaloids of Chelidonium majus L. and Their Inhibitory Activity against Acetylcholinesterase. Diploma thesis, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany and Ecology, Hradec Králové 2010, 64 p. The aim of diploma thesis was to process of pool of alkaloids of Chelidonium majus, chlorids insoluble in chlorophorm for at least one alkaloid isolated in pure form and for the determination of anticholinesterase, antihelminth and antioxidant activity. Of the pool in this thesis were isolated by column chromatography two alkaloids. Based on NMR and MS study was the first substance MN-1 identified as protopine. The second substance MN-2 was also subjected to MS and NMR structural studies and identified as allokryptopine. Both alkaloids were previously isolated from Chelidonium majus. The both isolated substances were subjected to studies on their inhibitory activity against human erythrocyte acetylcholinesterase and human serum butyrylcholinesterase. Values were determined (protopine: IC50 (AChE) = 423 ± 12,7 µM, IC50 (BuChE) = 322 ± 9,6 µM, allokryptopine: IC50 (AChE) = 250 ± 7,5 µM, IC50 (BuChE) = 530 ± 15,9 µM). Both alkaloids showed low activity in comparison. With standard alkaloid...
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Economic and controlling model in company Logos a.s.
Mazurek, Martin ; Mikovcová, Hana (advisor) ; Eisler, Jan (referee)
In my thesis I set up two main targets. First was the complete description of an economic and controlling model in a successful company Logos a.s., second was analysis and the definition of strong and weak parts of that model. In addition to that, I suggested several changes and modifications dealing with identified weaknesses and minimizing threats to the described economic model. In a theoretical part of the thesis, based on studies of a scientific literature, I characterized theoretical frame to related problems, which I later tried to solve in a practical part my work. I defined controlling and what problems it is exactly trying to cope with. After that I mentioned information about controlling implementation into the company. The end of the theoretical part was about planning, budgeting and managing of the company and its projects. In the practical part of the thesis I first identified reasons and aims for the implementation of a new economic and controlling model into Logos a.s., consequently describing the model in detail. Then, based on methodology of SWOT analysis and brainstorming during meetings with company managers, I identified strong and weak parts of the whole model. In the final part of the thesis I suggested implementing several improvements trying to eliminate identified weaknesses and threats of the economic model.
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Nursing Care for Women with Cervix Disease And Its Surgical Solution, i.e. Cervical Conisation And Reconisation.
NEDOROSTOVÁ, Veronika
In the Czech Republic there are diagnosed about 1 050 1 100 cases of cervical cancer a year. As percusors of this invasive cervical cancer are signed dysplastic changes of the cervix epithelium. These dysplasias belong to pretumorous processes marked as precancers. As the only acceptable way of medical attention of cervical precancer is considered a conical surgery performance or reexcision of reconization. This medical intervention is also connected with a pre - and post- operation care. This care belongs into the nursery process providing by a midwife. The thesis is devided into a theoretical and a practical part, ie researching. The theoretical part is focused on a qualitative research in combination with a quantitative one. The aim of a quantitative research were three survey quetions asking how women with this illness feel about nursing care and which knowledge they have about the pre and postcare regarding this illness. The quantitative research aimed at two hyphothesis supposing that the age of women with cervical cancer is decreasing and if they had the operation of cervical conization. The quantitative survey was done at the gynecology-maternity unit of the hospital in České Budějovice, a.s. There were six ladies who were tested on conization and reconization and the survey consists of nonstandard interviews concerning cervical cancer. Afterwards there was made a secondary analysis of collected data from nursing and medical documentation of the České Budějovice hospital a.s. in years 2005 2014 within the quantitative research. From the results of quantitative research is possible to prove that information about preoperation given to women is delegated to the surgery of their gynecologist who is irreplaceable for these situations. Midwives are also irreplaceable in passing this knowledge about the care before the medical assessment but they also show imperfection regarding knowledge about postoperation care.
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Study of dispersity of nanoemulsive drug carriers
Hájková, Hana ; Doležal, Pavel (advisor) ; Vachek, Josef (referee)
SUMMERY Theoretical part of this work is focused on explanation of such terms like nanoparticules and nanoemulsions and their usage within peroral and topical administration. Next part explains the merit of zeta potential and DLVO theory, which influence the stability of the elements. Off course, also the principle of the measuring of viscosity is mentioned, because viscosity is taken into consideration in case of measuring of the element dispersion. The experimental part is focused on determination of the partije size by photon correlation spectroscopy by temperature of 25řC and 37řC. The measurement was taken in chronological succession to estimate the stability of dispersion system. It was also measured electrokinetic parameter - zeta potential, which plays a fundamental role by keeping the stability of nanoemulsions. It was proved, that the size of the elements gets settled after approx. 1 week, further changes are not so striking anymore, not even by the increase of temperature to 37řC. Since creating the emulsion (approx. 1 week), the major share of the size of particles (about 60-95%) was ranging between 120-175 nm. As well zeta potencial remains in stable range (+2 mV - -0,6 mV) by the increase of temperature to 37řC and adding of three pH highs of buffers. From the gained results we can draw...
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Formation of spatio-temporal molecular gradients in early embryonic development of Xenopus laevis.
Šídová, Monika ; Tlapáková, Tereza (advisor) ; Pěknicová, Jana (referee) ; Petr, Jaroslav (referee)
Clarifying the underlying spatio-temporal mechanisms that determine body pattern is important for detailed understanding of embryonic development. A crucial question of vertebrate embryogenesis remains: when and how are single blastomeres determined for differentiation that subsequently leads to body axes specification and the formation of different tissues and organs? The answer to this question will be beneficial for primary research as well as in the field of applied medicine. The main aim of the presented thesis was to study spatio-temporal molecular gradients of cell fate determinants during early embryonic development. The African clawed frog Xenopus laevis was used as a model organism because of their large size of oocytes and external embryonic development. Due to late activation of embryonic transcription, a crucial mechanism of early blastomeres determination is dependent on asymmetric localization of maternal factors within oocyte and their uneven distribution into single blastomeres during early cell division. Two main localization patterns were identified along the animal-vegetal axis of the mature Xenopus oocyte using qPCR tomography. The localization gradient with preference in either animal or vegetal hemisphere was found for maternal mRNA as well as miRNAs. Moreover, two vegetal...
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Genetic and Ethiopatogenetic Aspects of the Restless Legs Syndrome
Kemlink, David ; Nevšímalová, Soňa (advisor) ; Martásek, Pavel (referee) ; Seeman, Pavel (referee)
The restless legs syndrome (RLS) is a sensomotor disoder characterized by urge to move lower extremities and this urge is usualy associated with unpleasnat sensations. The symtoms of RLS are alleviated with movement and, on the contrary, worsen during rest. The urge presents circadian rhytmicity peaking in the evening and the first half of night. The diagnosis of RLS is set according to patients' history fulfilling the essential criteria. The prevalence of RLS is quite high in western countries about 11%, women being affected twice as often as men. The disease has two forms, secondary and idiopathic. In the idiopathic RLS, positive family history is observed at about 50% of cases. There are already 3 genetic susceptibility loci on chromosomes 12, 14 and 9 published to be linked with RLS (RLS1, RLS2 a RLS3). Furhter 2 new loci were identified on chromosomes 17 and 4 insofar unpublished study. The current opinion suggests a complex model of inheritance in RLS. The aim of this project was to compare clinical and laboratory parameters in sporadic to familiar RLS and in families affected by RLS to confirm linkage previously detected loci, and eventually discover new susceptibility loci. The RLS patients were appart clinical evaluation examined with a set of hematological and biochemical tests, incuding...
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Comparison of the model of spatial planning in Sweden with the model used in the Czech Republic
Martinů, Jana ; Weingärtnerová, Markéta (advisor) ; Jílek, Petr (referee)
Bachelor thesis Comparison of the model of spatial planning in Sweden with the model used in the Czech Republic describes the planning models in these two countries. In the case of Sweden, it is a model of spatial planning. The Czech planning model is divided into two different units -- regional and urban planning. The work is divided into four separated parts. The first part is devoted to the characteristics of Sweden in terms of socio-economic structure, which is the basis for the description of the Swedish planning model. Another part focuses on models of planning in both countries. The main part of this work consists of the comparison of the two models; the spatial / territorial and the regional planning. Furthermore, the project will discuss the determination of identical and different features and will also describe the advantages and disadvantages of the Swedish model of planning in relation to the Czech model.
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