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Design and synthesis of ligands for selective copper(II) separation
Beliš, Marek ; Kotek, Jan (advisor) ; Smrček, Stanislav (referee)
Radioisotopes of copper are used in nuclear medicine for their physical properties. One step in process of preparing copper-containing radiopharmaceuticals is separation of copper radionuclides from other elements, especially zinc and nickel. The target of this Thesis is preparation of ligands based on linear tetraamine skeleton, which should be able of selective complexation and decomplexation of copper depending on pH of the solution. The Thesis contains synthesis of ligands, their NMR study and measurement of dissociation kinetics of their Cu-complexes. Powered by TCPDF (www.tcpdf.org)
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Polymer carriers for nuclear medicine
Sedláček, Ondřej ; Hrubý, Martin (advisor) ; Smrček, Stanislav (referee) ; Sedláková, Zdeňka (referee)
In the thesis, we developed and studied a novel polymer delivery system for the DNA-intercalator bearing radioisotope iodine-125. Auger electrons emitting radioisotopes (such as iodine-125 or indium-111) are a potentially effective cancer treatment. Their use as an effective cancer therapy requires that they will be transported within close proximity of DNA, where they induce double-strand breaks leading to the cell death. This type of therapy may be even more beneficial when associated with drug delivery systems. The DNA intercalators proved to be effective carriers for the delivery of Auger electron emitters into DNA. Therefore, the new radioiodinated DNA-intercalating ellipticinium derivatives were synthesized and characterized. These compounds were linked to N-(2-hydroxypropyl) methacrylamide copolymer with narrow molecular weight distribution via acid-sensitive hydrazone linker. The structure of the linker plays a crucial role in the biological effectivity of the delivery system, so it was optimized to be stable at pH 7.4 (representing the pH of blood plasma), whereas in slightly acidic pH in endosomes after the cell internalization, the radioiodine-containing biologically active intercalator is rapidly released from its polymer carrier. The intercalating ability of the active compound was...
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The role of radiologist assistant in radioiodine diagnostics and treatment of thyroid cancer
Hrbek, Jaroslav ; Táborská, Kateřina (referee) ; Vlček, Petr (advisor)
The bachelors thesis on the task of a radiological assistant during radioiodine diagnostics and treatment of thyroid gland carcinomas deals with the issue of thyroid gland carcinomas in the Czech Republic. It contains a brief overview of the types of carcinomas that affect the thyroid gland, their classification, diagnostics and therapy, concentrating on utilisation of modern examination methods and therapeutic practices, including among others application of radioiodine. The thesis also contains cases of four patients with similar diagnoses, the comparison of the development of whose respective illnesses I found interesting. Last but not least, the thesis includes a number of annexes comprising among others tables with important instructions for patients before and after application of radioiodine, and photographs from the site where the radioiodine application takes place Powered by TCPDF (www.tcpdf.org)
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Radioactive Waste in Hospital Facilities
Bradáč, Antonín ; Houdková, Lucie (referee) ; Tabasová, Andrea (advisor)
The thesis is focused on a little-known issue of institutional waste produced by hospitals, the creation, collection and subsequent disposal. This thesis described the distribution of waste from various aspects, especially the characteristics and their subsequent use in the effective elimination. This thesis deals with not only this issue, but trying to get closer to negative impact of ionizing radiation on the human body, not only in the current level of radiation protection, but also in terms of the historical development of different sources and work with them, especially in connection with the use of ionizing radiation in normal human activity but also through the list of nuclear accidents. The practical part of this thesis compares the three types of hospitals primarily on the basis of a personal meeting with the heads of various departments involved in the management of institutional waste, and materials derived their visit. Specifically, the hospital Atlas and Tomas Bata Regional Hospital (both situated in Zlin) and specialized workplace Masaryk cancer institute in Brno.
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Development of Imaging Methods and its Importance to Biomechanics
Sedláček, Tomáš ; Houfek, Martin (referee) ; Florian, Zdeněk (advisor)
The main objective of this bachelor thesis is to collect all available literature, from which can reader obtain basic knowledge of imaging methods. The methods are divided by its origin into four categories: x-rays, magnetic resonance, ultrasound and nuclear medicine. Each of them is described from the historical, physics and technological view. At the end the importance of each method to medicine and biomechanics is summarized.
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Values of accumulation of Tc-99m-DMSA in kidneys of children
HOMOLKOVÁ, Markéta
Scintigraphic examination of the kidneys and urinary tract allow you to get a lot of information about the condition of the urinary tract. The main contribution of nuclear medicine today is the ability to do a precise quantitative assessment of the various functions of the kidneys and urinary tract. Currently for static scintigraphy and renal SPECT uses the nuclear medicine Tc-99m-dimercaptosuccinic acid or DMSA. For children is being used Tc-99m-DMSA activity of at least 20 MBq. Static scintigraphy is usually performed to demonstrate acute pyelonephritis. In such a renal disease arises one or more bearings with reduced accumulation of the radiopharmaceutical, wherein the scar appears as a wedge-shaped defect, which has regular edges and kidney loses its volume. Another illness diagnosed by static scintigraphy is hypoplastic kidney, which has a smooth outer edge without defects in the crust. The above diagnostic method is also used to evaluate local changes in the transplanted kidney. The practical part of this work was to answer the following questions: "What is the normal accumulation of Tc-99m-DMSA in kidneys for children?" I got the answer through the exploration and evaluation of the results from a static scintigraphy examination of the reference group of 28 kidney of children done by Department of Nuclear Medicine, Hospital Ceske Budejovice. The reference data set was collected from September 2014 to March 2015 and consist of patients aged 0 18 years. The physician determined the patients without abnormal kidney or focal renal impairment to be selected for the reference group. I worked with the renal scintigraphy program, typing in specifying data about each individual patient and subsequently plotting areas of interest on the right and the left kidney for each of them. This program evaluated the percentage of accumulation of Tc-99m-DMSA in each kidney. Such a data I enrolled into a Microsoft Excel table and used statistical calculations to determine the normal accumulation of Tc-99-DMSA in child kidney. For statistical evaluation was used the formula for the average, standard deviation and percentiles. From the thus processed values may be noted that the normal value of accumulation of Tc-99m-DMSA child kidney ranges from 10.9% to 32.9%.
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The Radiation protection of Patients and staff in Nuclear Medicine.
DAŇOVÁ, Kristína
Open radioactive sources are used at the department of nuclear medicine for diagnoses and therapy, as well as for research purposes. Ionizing radiation is applied in all cases. Since a negative impact of this radiation has been depicted, it is necessary to systematically reduce the radiation on people, and protect the environment. The title of this bachelor thesis is: "Radiation protection of staff and operatives at the Department of Nuclear Medicine". This thesis is devided into several parts. The beginning of the theoretical part focuses on history of origins of radiation protection and institutions which deal with it. Further, nuclear medicine as such, its equipment, and structure of the department in general is described. The conclusion then introduces the DNM in the town of České Budějovice. Ionizing radiation and its biological effects on organisms were defined, as well as quantities and units which characterize it. A considerable part of this work focuses on principles of radiation protection, monitoring of the staff, workplace and releases. This work also deals with dosimetry and lists types of used dosimeters. It assesses the risks of outer and inner radiation. The aim of this thesis was to analyse laws and regulations which are connected to radiation protection and identify its effective application for staff and patiens of the DNM in České Budějovice. Another aim was to examine the radiation protection of patients at the Department of Nuclear Medicine, as well as the radiation protection of patients and staff at the inpatient ward. The research question was: "Is the radiation protection of patients and staff at the Department of Nuclear Medicine in hospital in the town of České Budějovice sufficiently optimized?" The method of research was assembling and recording materials of nuclear medicine in České Budějovice, compare doses of thermoluminescent dosimeters of the staff in outpatient and inpatient wards, and compare doses of finger and whole-body thermoluminescent dosimeters. The practical part provides detail information, charts and graphs of effective and equivalent doses of staff of outpatient and inpatient wards of the DNM in the town of České Budějovice between years 2009 and 2013. The outpatient ward comprises of fifteen employees. The inpatient ward of three nurses and one hospital attendant. These were observed in details for effective dose equivalents Hp(10) during each individual month for the period of five years. Results from the personal whole-body and finger dosimeters have been used for the analysis. The values of equivalent doses of HT from finger TLD are recorded for two of the employees. The data for the hospital in the town of České Budějovice was assessed by CSOD Ltd. In Prague, a company which has been providing dosimetric calculations in the Czech Republic for over tweny years. This data was compared with limits for radiation workers, which are regulated by State Office for Nuclear Safety no.389/2012 Sb., from November 16th, 2012, which changes the public notice of State Office for Nuclear Safety no.307/2002 Sb., about radiation protection as amended by public notice no.499/2005 Sb. The outcomes of the thesis have remitted a very high level of radiation protection and well-established measures in the protection of staff and patients against negative effects of ionizing radiation in the hospital of the town of České Budějovice. The thesis is then enhanced by a discussion, which reflects the outcomes compared with professional findings summarised in the theoretical part. The answer to the research quesion is: "Yes, radiation protection of the staff and patients at the Department of Nuclear Medicine in the hospital of the town of České Budějovice is sufficiently optimized." This bachelor thesis can be used as a study material for students of the field of study Radiology Assistant.
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The Dependency of the Volume Activity of I-131 in a Hospital Sewage Treatment Plant on the Amount of I-131 Used as a Medical Treatment in the Nuclear Medicine Ward
KAMPELSHEIMEROVÁ, Šárka
The subject of the work is radiation protection at a nuclear medicine workplace with a bed section in connection with the therapy of thyroid gland diseases using radioisotope 131I. In the theoretical part, the work briefly deals with the anatomy and pathology of the thyroid gland and ways of therapy, and outlines the basic characteristics of radioisotope 131I and history of nuclear medicine and radiation protection. In the practical part, there is a verification of the efficiency of radiation protection when handling liquid waste and a verification of the correlation of the activity of liquid waste with the activity of radiopharmaceutical administered. The malignant tumours of the thyroid gland constitute 0,5?1 % of all tumoral diseases. Some types of this tumour, which are histologically differentiated, retain the capability of extracting iodine from blood and are thus suitable for being treated using iodine radioisitope. That's why these types of tumour are treated most frequently at nuclear medicine departments. The basis of therapy is the surgical removal of tumoral tissue, usually of the whole thyroid gland, and administration of radioisotope 131I. When treating the thyroid gland, the patient is always hospitalized at a nuclear medicine department with a bed section. Radioisotope 131I is mixed ? and ? emitter and after being administred to a patient, it is the source of radiation danger for hospital personnel, possibly for others individuals. At the same time it is excreted from the organism by urine, stool and sweat. On that score due attention must be paid to safety measures. In view of the magnitude of this problem and the emphasis that is currently laid to protection against ionizing radiation, I chose this issue as a subject of my bachelor's work. The goal of the practical part of the work was to verify whether the limits set by Decree No. 307/2002 Coll., as amended by Decree No. 499/2005 Coll. on radiation protection were observed under the current system of handling liquid waste in the bed section of the Nuclear Medicine Department of the České Budějovice Hospital. Two hypotheses were set: Operation regulations and current programme equipment of the technical installations for the automatic draining of waste water from the bed section of the Nuclear Medicine Department are sufficient for the limits set by Decree not being exceeded; the other hypothesis assumes that the values of the volume activity of waste water in the drainage tank of the hospital's sewage plant conform to the activity of a radiopharmaceutical administered to patients treated at the Nuclear Medicine Department of the České Budějovice Hospital. For the purposes of this work, the activity of waste in the drainage tank of the hospital's sewage plant was measured with a well detector once a week for a period of two month to verify that the activity does not exceed a release level of 455 Bql-1 set in an addendum to Decree No. 307/2002 Coll. It was ascertained by measuring that the average activity of waste in the watched period was 279,8 Bql-1, the highest activity measured on March 18, 2013 being 373 Bql-1. In the watched period, the release activity set by the law was not exceeded in any week. At the same time, the correlation of the values of radioactivity administered with the radioactivity of waste water was proved. Consequently, both hypotheses of the work were proved. The work proved that the limits set by Decree No. 307/2002 Coll., as amended by Decree No. 499/2005 Coll. on radiation protection, were observed under the current system of handling liquid waste in the bed section of the Nuclear Medicine Department of the České Budějovice Hospital.
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Computation of relative function of kydney at dynamic scintigraphy - influence of time period applied for computation.
HRTÁŇOVÁ, Jana
The topic of my bachelor thesis is a computation of relative renal function at dynamic scintigraphy and an influence of the time period applied for computation. The main aim of the thesis is to establish if the usage of two different time periods for computation of relative function of kidneys at dynamic scintigraphy of kidneys has any influence on computed function. Precisely, whether the choice of time period affects the result of processing the study is acquired by dynamic scintigraphy of kidneys. Expressed hypothesis assumes that time periods between 60s and 180s which were chosen for the calculation have not the influence on calculated relative function. Dynamic scintigraphy of kidneys enabling to display function of kidney´s ability to clean blood from the observed substance and consider possible defect of kidney excretion, it is the important method of examination mainly by children patients which are the vast majority of examined patients. For the hypothesis confirmation, there was created a reference file. This file consists of children patients who were examined by dynamic scintigraphy of kidneys in the Department of Nuclear Medicine Hospital in Czech Budejovice. With a help of program of dynamic scintigraphy the relative function of kidney was computed and defined by the percentage portion of each kidney on the whole renal function. The different time periods were used for the function curve for the computation. The function curve is designed like a graph from the marked region of interest and it is the result of computer processing data which were obtained from the scintigraphic study. From obtained values, the tested criteria are subsequently determined by statistical calculations they are confirmed and given as a zero hypothesis.
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