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Iodine in food
Laba, Marija ; Babák, Libor (referee) ; Vránová, Dana (advisor)
This research addresses the importance of iodine as a micronutrient for the human body. Although it seems that the required daily intake is small and it is calculated in micrograms, it is equally important for the organism. The issue deals and summarizes the occurrence of this element in food. Insufficient or excess intake causes serious illness. Based on this research, it is possible to imagine a supply of iodine in the Czech Republic and in the world. The collected information shows that iodine intake is different and it is depending on food, health status or age. The locality in which we live plays a big roli. Currently the salt iodization and wrong eating cause the growing problem of excessive intake of iodine in the body. Since the problem is solved only in theory, we can find a description of the most ideal method for determining the amount of iodine in food.
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Thyroid Gland Activity in Horses
ŠINÁKLOVÁ, Petra
The bachelor thesis focused on the thyroid gland activity in horses assesses the thyroid gland activity in the selected group of horses based on the production of thyroid hormones (TT4, TT3, fT4 and fT3). Blood was taken from vena jugularis on a one-time basis in cooperation with private veterinarians. Afterwards the levels of thyroid hormones were measured by the RIA method. The thyroid gland activity was evaluated in a total of 12 horses (8 geldings and 4 mares) in the Region of South Bohemia. The average age was 8.5 years. In the tested samples the total T4 hormone was 37.24 +- 9,88 nmol-l-1 on average, while the total T3 hormone was 0.99 +- 0,23 nmol-l-1 on average. Free fractions of T4 hormone was 13.28 +- 2,66 pmol-l-1 on average and free fraction of T3 hormone was 5.43 +- 1,42 pmol-l-1. The highest level of TT4 hormone was measured in hot blood horses (46.03 nmol.l.-1), while the lowest level was in the group consisting of ponies and Huculs (27.86 nmol.l.-1). The highest value of TT3 hormone was in the group of ponies and Huculs (1.13 nmol.l.-1) and the lowest value in cold blood horse breeds (0.74 nmol.l.-1). The highest level of fT4 was in cold blood horse breeds (14.73 pmol.l.-1), while the lowest level was in hot blood horses (12.68 pmol.l.-1). The level of fT3 hormone was highest in hot blood horses (6.02 pmol.l.-1), while the lowest level was in cold blood horses (4.78 pmol.l.-1). The concentration of the total T4 and T3 was higher in mares than in geldings, namely by 1.81 nmol-l-1 and 0.05 nmol-l-1, respectively. By contrast, the concentration of free T3 was lower in mares than in geldings, namely by 0.32 nmol-l-1. The concentration of free T4 was also higher in mares than in geldings, namely by 1.31 nmol-l-1. When comparing our results with the reference values, it is obvious that the concentration of thyroid hormones was at the upper limit of the physiological range or slightly above the limit so lack of iodine and the related reduced thyroid gland activity cannot be presumed in those horses. The relations between the level of the thyroid gland activity and Ca concentrations in blood plasma concurrently with the activity of the alkaline phosphatase (ALP) enzyme were ascertained. The correlation coefficients showed a negative effect of an increased thyroid gland activity on the bone tissue metabolism and increased decalcification.
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Food supplements and iodine supplementation in pregnancy
VAVROUŠKOVÁ, Edita
Iodine is a trace element tremendously important for thyroid gland hormone production. It affects normal evolution of brain, especially in the time of intrauterine development and in the first year of child's life. Deficiency of iodine can lead to creation of pregnancy goiter, it also decrease the probability of carrying fetus to term and increase the probability of disorder in psycho-motoric evolution of child. Czech Republic is geographically lined up among the regions with lack of iodine in natural sources and food. However, nowadays the iodine deficiency is considered to be managed. But risk groups of population still exists, especially pregnant women can be endangered by lack of iodine, because the need of iodine intake in pregnancy increases to 200 250 ug per day and this level must be ensured. Consumption of food rich in iodine can cover the increased need of iodine. Significant source of iodine is milk and milk products. Another source is table salt enriched with iodine, but its daily intake is limited. Rich sources of iodine like sea fish, sea products and seaweed rarely occur in our diet. The goal of thesis was to evaluate intake of dietary supplements with iodine by pregnant women and evaluate women's awareness of higher iodine need and iodine food sources. Quantitative research in form of questionnaires was chosen for getting information from higher number of individuals. The questionnaire consists of 15 questions. Answers were gained from 118 respondents living in Central Bohemia, Moravia-Silesia region, Liberec region, region Highlands and South Bohemia. Questionnaire was distributed to gynecological ambulances by employees of State health institution. I visited gynecological ambulances in South Bohemia personally. By evaluation of questionnaire was found out that dietary supplement with iodine use 63 % pregnant women in researched population. All respondents always use only one type of dietary supplement. Among the most used belong "Chytré miminko", "GS mamavit" and "Femibion 800". 68 % of respondents know the importance of higher iodine intake in time of pregnancy. Question about daily recommended dosage was correctly answered only by 35 % of respondents. As a food sources of iodine the pregnant women know sea fishes, sea products, seaweed and table salt enriched with iodine. But 90 % of respondents are not familiar with milk and milk products as important source of iodine. Pregnant women should be better informed about importance of sufficient supply of iodine and about sources of iodine by gynecological ambulances. Information about mentioned issues should occur in magazines, education materials and internet articles more often. Respondents were notified of issues and important role of iodine in time of pregnancy by questionnaire. It is very probable that women found correct answers on the internet or in publication for expectant mothers after filling in the questionnaire.
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Dietary supplements and iodine supplementation for children 11-12 years in the Czech Republic
HALÁSZOVÁ, Monika
Bachelor Thesis called "Dietary supplements and iodine supplementation for children 11-12 years in the Czech Republic" deal with the intake of dietary supplements containing iodine and intake of other significant dietary sources of iodine in relationship to saturation with iodine in the monitored group of 300 children aged 11-12 years . The thesis is divided into theoretical and practical part. Theoretical part deal with established issues in light of current situation and uses the knowledge of specialized literature in these areas: iodine and his dietary sources, influence of deficient or excessive intake of iodine on thyroid gland and its function, and also the solution to iodine deficit in Czech Republic. The thesis also deals with dietary supplements and nutrition of school-aged children. Practical part is focused on quantitative research. This research was done on selected group of children who had low level of ioduria (iodine in urine) according to State health institution. Statistical file included 300 children of both gender in age from 11 to 12 who live in Czech Republic. The reason why children of this age were chosen is because of importance of optimal intake of iodine in period of physical and sexual evolution. The children were divided into two groups. One group had ioduria up to 300ug/l and the second group had ioduria over 300u/l. Data were collected through questionnaire. Because of age of respondents, the questionnaire was filled in presence of at least parent. The questionnaire should have also served to parents as information about iodine importance for their children. The individual evaluation of ioduria and questionnaire was given to parents upon their request. Collected data were evaluated in Microsoft Excel. In practical part, two main goals and two research questions are set. Their task is to determine the rate of usage of dietary supplements with iodine and to find out what significant sources of iodine the children with ioduria over 300u/l take in. The milk and milk products, salt with iodine, salted delicacies, sea products and dietary supplements with iodine were observed as probable main sources of iodine intake. The first goal was to find out the amount of iodine intake from dietary supplements for previously mentioned group of children. The second goal was to find out if the dietary supplements with iodine (or any other combination of food rich on iodine) are used by observed individuals with ioduria over 300u/l. The results of research show if the respondent's level of ioduria is affected by in taking the dietary supplements or food with significantly higher content of iodine. My own research proved relatively frequent (but irregular) intake of dietary supplements with iodine by whole examined population. On the other hand, usage of dietary supplements with iodine is probably not correlated with usage of table salt without iodine or with thyroid gland illness by individual respondent or in his family. The milk and milk products and table salt with iodine proved to be the main source of iodine. According to research, children with excessive ioduria consume sources of iodine as frequent as other children. Deeper insight into results shows that reason for excessive saturation with iodine is combination of intake of dietary supplements as well as other significant food sources of iodine, especially milk and its products. By several respondents, the higher level of ioduria can be caused by higher consummation of sea products or by usage of dietary supplements with iodine in last two days. The need for better awareness about suitable rate of iodine dietary supplements intake as well as medical importance for lowering the amount of (iodine) table salt in food was discovered by research. The optimal supply of iodine by higher percent of observed population could be also achieved by optimizing the content of iodine in milk.
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Activity of the thyroid gland of cattle
KŘÍŽOVÁ, Zuzana
The thesis deals with the evaluation of the impact of different quantities and forms of iodine in ration dairy cows on the concentration of hormones of the thyroid in the blood plasma. The experiment was done with a herd of Red cows breeding in the conversion to breed in the breeding of Holstein dairy cows in Klatovy. Iodine was given in both inorganic and organic form. Before experimenting, the value of total and free forms of hormones was very low. During the experiment, increased concentrations of hormones in connection with the intake of inorganic iodine, the significant deviations showed free forms of thyroid hoemones. Nevertheless, the addition of organic iodine was not fully substituted for the reduction of inorganic iodine content. The thesis also discusses the assessment of the thyroid status by Czech red cattlebreeding on the school farm. The aim was to compare the activity of the thyroid gland in high-yield dairy cows breeding in a barn environment and cattle on pasture reared cattle. For red cattle reared on pasture, there were characteristically higher concentration levels of total and free hormones compared with high yield dairy cows. Nevertheless, in comparison with the reference value,there was a concentration of TT4 for Czech red cattlelower, it coresponded well as dairy cows, rather lower iodine supply. In connection with the rise (higher content) TT4, possibly fT4, there was a similar tendency for the TT3 and fT3, so we can´t assume a deeper state of iodine deficiencies and its associationwith an underactive thyroid gland.
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COWS MILK AS A NATURAL SOURCE OF IODINE IN HUMAN NUTRITION
VÍTKOVÁ, Lucie
This thesis deals with the importance of milk as a natural source of iodine in human nutrition. The thesis provides a data of the consumption of milk and milk products and their contribution to the protection needs iodine for students and employees of the University of South Bohemia in Ceske Budejovice. The experiment includes a total of 60 people (20 men and 40 women). Empirical data wasobtained within the grant project named GAJU 011/2013/Z and NAZV QH 81105. Data of consumption of milk and milk products were obtained through questionnaires. For men, average weekly consumption of milk was 826.5? 835.1 ml (118.1 ml per day) and for women 912.4? 783.9 ml (130.3 ml per day). Average consumption of yogurt for men was 361.0? 401.4 g per week (51.6 g per day), for woman 428.4? 338.8 g per week (61.2 g per day) and average consuption of cheese was for men 263.0? 240.5 g per week (37.6 g per day) and for woman was 260.2? 226.5 per week (37.2 g per day). Through the milk and milk products tested, men average 81.6 g of iodine per day, woman adopted 93.4 g. According to the results, the amout of consumed milk and milk products was lower than the nationwide average, but still covered more than half of daily iodine needs. The thesis presents the data of the iodine concentration in urine for students and employees of the University of South Bohemia in Ceske Budejovice (n=62) as an indicator of iodine supply to the organism. The average iodine content in urine of all subjects (men and women) was 230.4? 171.3 gl-1, for men (n=21) reached 244.6? 195.2 gl-1, for women was 223.2? 159.8 gl-1. Results of the average iodine content in urine reflected the physiological range, i.e. for the students and employees of the University of South Bohemia was supply of iodine in organism sufficient. The thesis also provides information about the amount of iodine in asamples of cow´s milk on a selected farm (n=50) of the Jihocesky region, the Plzensky region and Vysocina during the years 2011 - 2013. Samples of cow´s milk were obtained in collaboration with the Central Laboratory of dairy Madeta a.s in Ceske Budejovice and Veterinary Centre s.r.o Susice. In 2011, the average concentration of iodine was 321,0? 337.8 gl-1, in 2012 was concentration of iodine 298.8? 290.8 gl-1 and in 2013 was 234.7? 116.1 gl-1 also otherwise: in all years was it was determined that there was an abundance of iodine. The highest values (315.6? 305.1 gl-1) of iodine was in the Jihocesky region. In Vysocina a lower average level of the iodine was detected (9.5 %), as well as in the Plzensky region where the amount of iodine in milk was lower by 53.7 %, compared to the South Bohemia region and 48.8 % compared to the Vysocina region.
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Postnatal dynamics of thyroid hormones in lambs
BURLEOVÁ, Barbora
The aim of my work was to monitor and valorize of postnatal dynamics of thyroid hormones, thyroxine (TT4), triiodothyronine (TT3) and its free fractions (FT3 and FT4), in lambs up to 60 days of age. During the experiment 26 lambs were devided into two groups according to sex and were supplemented by iodine in concentration 0,7 ? 5 mg. Standard directed day ration for sheep is average 0,3 mg of iodine in 1 kilogram of dry mass (DM). One of the groups was also supplemented by selenium in concentration 0,2 ? 0,4 mg in 1 kilogram of DM.
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The Dependency of the Volume Activity of I-131 in a Hospital Sewage Treatment Plant on the Amount of I-131 Used as a Medical Treatment in the Nuclear Medicine Ward
KAMPELSHEIMEROVÁ, Šárka
The subject of the work is radiation protection at a nuclear medicine workplace with a bed section in connection with the therapy of thyroid gland diseases using radioisotope 131I. In the theoretical part, the work briefly deals with the anatomy and pathology of the thyroid gland and ways of therapy, and outlines the basic characteristics of radioisotope 131I and history of nuclear medicine and radiation protection. In the practical part, there is a verification of the efficiency of radiation protection when handling liquid waste and a verification of the correlation of the activity of liquid waste with the activity of radiopharmaceutical administered. The malignant tumours of the thyroid gland constitute 0,5?1 % of all tumoral diseases. Some types of this tumour, which are histologically differentiated, retain the capability of extracting iodine from blood and are thus suitable for being treated using iodine radioisitope. That's why these types of tumour are treated most frequently at nuclear medicine departments. The basis of therapy is the surgical removal of tumoral tissue, usually of the whole thyroid gland, and administration of radioisotope 131I. When treating the thyroid gland, the patient is always hospitalized at a nuclear medicine department with a bed section. Radioisotope 131I is mixed ? and ? emitter and after being administred to a patient, it is the source of radiation danger for hospital personnel, possibly for others individuals. At the same time it is excreted from the organism by urine, stool and sweat. On that score due attention must be paid to safety measures. In view of the magnitude of this problem and the emphasis that is currently laid to protection against ionizing radiation, I chose this issue as a subject of my bachelor's work. The goal of the practical part of the work was to verify whether the limits set by Decree No. 307/2002 Coll., as amended by Decree No. 499/2005 Coll. on radiation protection were observed under the current system of handling liquid waste in the bed section of the Nuclear Medicine Department of the České Budějovice Hospital. Two hypotheses were set: Operation regulations and current programme equipment of the technical installations for the automatic draining of waste water from the bed section of the Nuclear Medicine Department are sufficient for the limits set by Decree not being exceeded; the other hypothesis assumes that the values of the volume activity of waste water in the drainage tank of the hospital's sewage plant conform to the activity of a radiopharmaceutical administered to patients treated at the Nuclear Medicine Department of the České Budějovice Hospital. For the purposes of this work, the activity of waste in the drainage tank of the hospital's sewage plant was measured with a well detector once a week for a period of two month to verify that the activity does not exceed a release level of 455 Bql-1 set in an addendum to Decree No. 307/2002 Coll. It was ascertained by measuring that the average activity of waste in the watched period was 279,8 Bql-1, the highest activity measured on March 18, 2013 being 373 Bql-1. In the watched period, the release activity set by the law was not exceeded in any week. At the same time, the correlation of the values of radioactivity administered with the radioactivity of waste water was proved. Consequently, both hypotheses of the work were proved. The work proved that the limits set by Decree No. 307/2002 Coll., as amended by Decree No. 499/2005 Coll. on radiation protection, were observed under the current system of handling liquid waste in the bed section of the Nuclear Medicine Department of the České Budějovice Hospital.
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Concentrations of thyroid hormones in the blood plasma of sheep
DŘÍZHALOVÁ, Blanka
The theoretical part of the thesis is dealing with description of the thyroidal hormones thyroxine, triiodthironine and their active (unbound) variants in the blood plasma. Thyroid gland, where the hormones are produced, production of very hormones and their effect on whole organism is described here. The practical part tracks and analyzes mutual relations and dynamics of thyroid hormones of sheep in their plasma depending on upraised uptake of iodine and changing uptake of selenium. The results are processed statistically.
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Thyroid hormones in blood plasma of dairy cows
KŘÍŽOVÁ, Zuzana
Thesis deals with the evaluation of the impact of different quantities and forms of iodine in ration dairy cows on the concentration of hormones of the thyroid in the blood plasma. Iodine was given in the inorganic (Vitamix S7+) and organic form (UNI-SATURAN J). The experiment was done with a herd of Red cows fleckvieh breeding in the conversion to breed in the breeding of Holstein dairy cows in distrikt Klatovy. The average concentration of thyroxine (TT4) before experiment was 50.91+-12.96 nmol/1, 1.6+-0.53 nmol/l of trijodthyronine (TT3). Free forms of hormones showed: FT4 1.09+-0.06 pmol/l and FT3 2.5+-0.08 pmol/l. Free forms of hormones showed more considerable divergencies.
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