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Adherence to calcium and vitamin D supplementation in women with postmenopausal osteoporosis
Holcová, Radka ; Vytřísalová, Magda (advisor) ; Fuksa, Leoš (referee)
Adherence to calcium and vitamin D supplementation in women with postmenopausal osteoporosis Author: Radka Holcová Supervisor: Magda Vytřísalová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Introduction: The insufficient medication adherence is a very frequent problem with chronic asymptomatic diseases as osteoporosis which significantly influences the treatment outcome. The successful osteoporosis therapy is based on adequate supply of calcium and vitamin D. A lot of studies are focused on the adherence to antiresorptive treatment but the adherence to supplementation therapy is rarely evaluated. Aims: The aim of the study was to evaluate the adherence to calcium and vitamin D supplementation in women with postmenopausal osteoporosis. Methods: The adherence was evaluated using two different methods: self-reported questionnaire and the electronic monitoring by bottles type Medication Event Monitoring System (MEMS). This partial analysis of a multicentre study includes and assesses data from Osteocentre in Pardubice Regional Hospital. Results: The analysis was performed with 15 women (the average age of 73). The patients were treated with Caltrate 600 mg/400 IU D3 once a day for three months. The adherence during the entire period...
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Hypertension and Nutrition: Fat-soluble Vitamins A, D and E
Weber, Jakub ; Vlček, Jiří (advisor) ; Hronek, Miloslav (referee)
Hypertension and nutrition: Fat-soluble vitamins A, D and E Weber J1 , Vlcek J1 , Suarez-Varella MM2 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic 2 Department of Preventive Medicine and Public Health, Faculty of Pharmacy, University of Valencia, Spain Arterial hypertension (AH) is a disease affecting population globally, and thus considered as a problem of public health and socioeconomic. Studies are trying to identify the connection between diet and the prevalence of arterial hypertension. Objective of the study was to determine possible association between an occurrence of AH and fat-soluble vitamins A, D and E intake. The nested, case-control population study investigation was grounded on database from the Spanish Hortega study, and performed on a random sample of 1,514 people (50.3 % women, 49.7 % men). From this sample we selected those aged ≥ 40 years old and untreated for hypertension and divided them into two groups: non-hypertensive (n = 429; 63.6 %) (controls), and newly diagnosed AH (n = 246; 36.4 %) (cases). Biochemical and anthropometric measurements, data on dietary intakes, education, socioeconomic status, place of residence, health habits, comorbidities, consumption of alcohol and tobacco were used for our...
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Multidisciplinary rehabilitation for pubescents patients with cerebral palsy
Buzková, Tereza ; Nývltová, Lucie (advisor) ; Zounková, Irena (referee)
Cerebral palsy is a non-progressive motor funciton development disorder which is caused by disruption of the immature brain. There is about 16 000 - 20 000 patients living in the Czech Republic with this diagnosis to date. Based on the clinical picture, specific forms of this disorder can be classified. Besides the motor funciton development disorder, the patients also suffer from other comorbidities (such as epilepsy, oropharyngeal dysphagia, sensory deficits etc.). Early diagnosis of this disorder is crucial. The severity of the motor function deficit is evaluated by monitoring the gross and fine motor function. Cerebral palsy is a non-progressive, not unchanging, disorder. The theoretic part of the thesis describes secondary issues which are present during pubescent period of the patients. They are dealing with growth disorders, reduced bone density and increased bone fragility. Plenty of risk factors precede these problems. Also, question of sexuality, life priorities and about future play a big role for the patients in their pubescent period. There are possibilities to solve these problems in terms of complex rehabilitation care. Especially in physiotherapy, occupational therapy and nutritional therapy. The practical part of the thesis is an example of an intensive rehabilitation care of a...
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Risk factors of osteoporosis and fractures in people over 65 years of age
Malimánková, Jana ; Zikán, Vít (advisor) ; Šimková, Simona (referee)
This diploma thesis deals with risk factors of osteoporosis and fractures among people older than 65 years. Theoretical part contains the definition of osteoporosis, physiology of bones, hormonal regulation, determinants of disease, clinical manifestation, prevention of disease and old age. Essential chapters of theoretical part are about moving activity and nutrition. Aim of this thesis was to evaluate the occurrence of osteoporosis and risk factors of fractures in connection with risk nutritional factors. The research includes 86 responders, who filled out the questionnaire of risk factors and the risk of fractures was found out using FRAX tool. Based on these results patients were divided into 2 groups: with high risk and low risk of fractures. 10 patients of each group provided 3-day menu. The densitometric examination was accomplished to 30 responders and the probability of fracture formation was evaluated. The results of diploma thesis show, that 45 % of responders have higher risk of fracture formation. This group has significantly higher age and lower BMI. This research then showed that patients with higher risk of fracture formation get significantly less energy, proteins, fats, carbohydrates, and calcium. Moreover, most of participants has insufficient intake of dairy products and fish....
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The role of nutrition in the treatment of osteoporosis
Večeřová, Vendula ; Zikán, Vít (advisor) ; Kytnarová, Jitka (referee)
Introduction: Osteoporosis is one of the most frequent bone metabolic disease. It is a systemic metabolic skeleton disease, where the architecture of bone tissue is damaged due to the loss of bone mass, and therefore the bone quality is reduced. Thus, it comes to increased bones fragility and reduction in mechanical resistance, which leads to a higher risk of fractures. The principle of pathogenesis is an imbalance between resorption and bone formation. Due to increasing lifetime and lifestyle changes, the prevalence of the disease increases. Aim: The aim of the practical part of the diploma thesis is to evaluate the eating habits of postmenopausal women treated for osteoporosis and to evaluate their nutritional condition in relation to bone mineral density (BMD). Methods: Nutritional habits were obtained and evaluated through a questionnaire survey. Three-day meal records were collected and analysed using the Nutriservis Profesional nutritional software, to determine the energy intake and selected nutrients. Osteodensitometric data were measured using dual emission X-ray absorptiometry (DXA). Results: The analysis of the diet showed that the observed group of women consumes an excessive amount of energy on average, especially in form of fats. Higher intake of protein was also observed....
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Problems in prevention of vitamin D and calcium deficiency in geriatrics
Prokopová, Michaela ; Vágnerová, Tereza (advisor) ; Kvasničková, Ivana (referee)
Vitamin D and calcium are essential for the health of the elderly population. Due to the changes that occur in the body during aging, it is necessary to monitor the intake of these micronutrients and, if necessary, to supplement or substitute them appropriately. This thesis focuses on prevention of vitamin D and calcium deficiency in old age. The theoretical part explains the function of vitamin D and calcium in the human body, their metabolism, sources and problems of deficiency or excess. There is information about diseases related to the deficiency, especially osteoporosis and sarcopenia. The practical part has two sections. The first analyses the data from the SPRINTT trial. Data related to vitamin D, calcium, their supplementation and sarcopenia, as a disease associated with vitamin D deficiency, were used. The second section analyzes the data from a questionnaire survey in nursing homes, which obtained information about the health of seniors, the frequency of consumption of selected foods and vitamin D and calcium supplementation. Using data from the SPRINTT, it was found that 55 % of men and 40 % of women had the values of sarcopenia. 11 % of the participants had vitamin D deficiency. The data from the questionnaire found that only 51 % of respondents over the age of 70 supplemented with...
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Multidisciplinary rehabilitation for pubescents patients with cerebral palsy
Buzková, Tereza ; Nývltová, Lucie (advisor) ; Zounková, Irena (referee)
Cerebral palsy is a non-progressive motor funciton development disorder which is caused by disruption of the immature brain. There is about 16 000 - 20 000 patients living in the Czech Republic with this diagnosis to date. Based on the clinical picture, specific forms of this disorder can be classified. Besides the motor funciton development disorder, the patients also suffer from other comorbidities (such as epilepsy, oropharyngeal dysphagia, sensory deficits etc.). Early diagnosis of this disorder is crucial. The severity of the motor function deficit is evaluated by monitoring the gross and fine motor function. Cerebral palsy is a non-progressive, not unchanging, disorder. The theoretic part of the thesis describes secondary issues which are present during pubescent period of the patients. They are dealing with growth disorders, reduced bone density and increased bone fragility. Plenty of risk factors precede these problems. Also, question of sexuality, life priorities and about future play a big role for the patients in their pubescent period. There are possibilities to solve these problems in terms of complex rehabilitation care. Especially in physiotherapy, occupational therapy and nutritional therapy. The practical part of the thesis is an example of an intensive rehabilitation care of a...
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The effect of serum 25-hydroxycholekalciferol levels on musculoskeletal system in children with inflammatory bowel disease
Maratová, Klára ; Šumník, Zdeněk (advisor) ; Zapletalová, Jiřina (referee) ; Kutílek, Štěpán (referee)
The effect of serum 25-hydroxycholekalciferol levels on musculoskeletal system in children with inflammatory bowel disease Background: Low bone mineral density and osteoporosis represent severe secondary complications that can be a result of childhood chronic disease. According to Frost's mechanostat theory impaired muscle functions may contribute to the changes observed on the skeleton. Aims: The aim of this study was to: 1) evaluate parameters of bone mineral density, bone geometry and dynamic muscle functions in children and adolescent with chronic disease - inflammatory bowel disease (IBD) and type 1 diabetes (T1D); 2) evaluate a possible effect of vitamin D deficiency and vitamin D supplementation or duration of the disease on the musculoskeletal unit; 3) determine clinical or laboratory predictors of muscle and bone parameters. Methods: The study was divided into two substudies according to the diagnosis. Seventy patients with IBD (median age 13.8 years) were included in one study, fifty-five of which completed all of the planned procedures. During the study, IBD patients were supplemented with 2000 IU/d of vitamin D. In the second study 95 patients with T1D were included (median age 16.4 years). BMD and bone geometry of non-dominant tibia was evaluated using peripheral quantitative computed...
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Význam vitaminů ve výživě velbloudovitých
Turčeková, Radka
Turčeková, R. The efect of the vitamins in camelids diet. Bachelor thesis. Brno, 2017. The main goal of this thesis is to describe, on the basis of a literary review, the zoological classification and morfological and physiological traits of camelids with a focus on the metabolism of vitamins. Because of a number of physiological adaptations for living in their natural environment it is necessary to provide a higher dose of some vitamins (mainly vitamin D) while keeping camelids in different climate conditions. This thesis subsequently presents all basic vitamins soluble in water and in fat, describes their physiological functions and health issues related to their lack or redundance. Circumscribed specifics of the vitamin metabolism of camelids show a need of knowledge and respect of physiological traits and coherent nutrition needs of species bred out of the region of their natural presence.
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