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Laboratory diagnostics of multiple myeloma.
Hubálková, Blanka ; Kovařík, Miroslav (advisor) ; Vrbacký, Filip (referee)
Multiple myeloma is one of the main representatives of monoclonal gammapathy diseases. It is caused by malignant transformation of B-lymphocytes, its clonal proliferation and accumulation of terminal stages of plasmocyte maturation. Clinical diagnosis is based on presence of this monoclonal immunoglobulin in serum or urine, myeloma cells infiltration into bone marrow and finding osteolytic lesions in bones. The electrophoresis and immunofixation of monoclonal immunoglobulins, free light chains assay, cytology of bone marrow aspirate are the most important laboratory tests helping in the statement of this immunoglbuline. The proof of the osteolytic damage is made using imaging technologies, such as RTG. Treatment of multiple myeloma had significantly improved during last years. The main options of therapy include high-dose chemotherapy and autological transplantations, together with immune modulating drugs, such as thalidomide, lenalidomide and bortezomib. Experimental part was focused on the comparison of sensitivity of paraprotein assessment by electrophoresis, immunofixation and free light chains assay. We can assume on the base of the results of the work that the free light chain assay is less sensitive method compared to k/I index. In addition - the higher sensitivity of IFO in comparison with...
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Signs oF degradaTion oF czech arT nouveau mosaic glasses
Rohanová, D. ; Švarcová, Silvie ; Hájek, T.
Analyses of Art Nouveau mosaics from the church of St. Simon and Juda in Dolín near Slaný and from Holovousy, both most likely made by the workshop of Viktor Foerster, have shown that the author used the NaO-PbO-SiO 22 glass type and that he used the same glass also for restoration of The Last Judgment mosaic at the Prague Castle in 1890-1910. Despite the fact that lead glasses are more durable than potassium glasses, the material investigations identified corrosion processes on the surface of the glass pieces (tesserae) depending on their composition. Apart from the analyzed mosaic NaO-PbO-SiO2 glasses, we also used ancient sodium glasses (NaO-CaO-SiO2) and 22 potassium glasses (K2O-CaO-SiO2) from archaeological finds in Opava to demonstrate their different chemical durability. We also paid attention to fixation binders used in Art Nouveau mosaics. Inappropriate use of gypsum-containing binders is a significant cause of disintegration of the mosaics. Gypsum and gypsum-lime plasters are very sensitive to humidity. Capillary action of water is a very serious problem that endangers the overall lifespan of any mosaic.
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Communication Taboo in the Family
Michalíková, Klára ; Rampouchová, Jaroslava (advisor) ; Krahulcová, Beáta (referee)
In the preface of this work I talking about quality of our life. Work on the assumption life should be lived as good as possible. We can't do this without understanding who we are? What we are feeling? What we need? What our neighbour need? What they are feeling? It's obvious, our family formed us in the most sensitive period of our life. We are without experiences, vulnerable. We will formed our children in the same way. I show the taboo from the many views and positions. Taboo is unremitting and still changing component of our lifes. The separation taboo from natural keeping secrets - privacy is very important. I used taboo as an affect negatively instrument in family communication. Taboo can interrupt the family communication.
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Predatory journals in Scopus
Macháček, Vít ; Srholec, Martin
The study maps the penetration of so-called “predatory” scholarly journals into the citation database Scopus. Predatory journals exploit the author pays open access model, and conduct only cursory or no peer review, despite claims to the contrary. Some such journals will publish almost anything for money. In the Czech context whether a journal is indexed in Scopus is crucial for determining the points that publications in that journal are awarded in the national performance-based evaluation of research organizations, which in turn is the basis for the allocation of institutional funding. Hence, in this evaluation framework, publishing in predatory journals that are indexed in Scopus has a clear “fiscal” advantage.
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Study of diversity of weed communities in wide row crops in Podkrkonoší Region
Kocour, David ; Kolářová, Michaela (advisor) ; Václav, Václav (referee)
The main aim of the master's thesis was an assessment of weed communities in Podkrkonosi Region (the area underneath the Giant Mountains) (Pokrkonosi). The effect of the crop (maize, potatoes) and altitude with a particular focus on thermophilic weed specieshas been investigated.
The theoretical part outlines weed species referring to their significance, classification, harmfulness as well as benefits. The effect of climate changes, invasive plants, biodiversity and effect of temperature are discussed. Last part of the literary review is a brief description of model crops.
In the practical part of the thesis, soil and climate conditions of the locality are described. Furthermore, a term phytocoenology is introduced and the methodology of recording relevés and the data conversion are explained. Totally, 99 weed species out of 25 families were found (69 in maize, 85 in potatoes).
Chenopodium album agg., Echinochloa crus-galli and Fallopia convolvulus were the most frequent species in maize. The species with the highest cover were Fallopia convolvulus, Chenopodium album agg. and Echinochloa crus-galli.
Chenopodium album agg., Echinochloa crus-galli and Viola arvensis were the most frequent in potatoes. Chenopodium album agg., Fallopia convolvulus, Echinochloa crus-galli and Galinsoga quadriradiata can be classified as the weeds with the highest cover.
Euphorbia helioscopia and Sonchus arvensis were positively correlated with increasing altitude, while Amaranthus retroflexus, Solanum nigrum and Galinsoga quadriradiata were negatively correlated. Thlaspi arvense and Echinochloa crus-galli were characteristic species in maize, and Veronica persica, Galinsoga quadriradiata and Sonchus arvensis in potatoes.
It can be concluded that potatoes fields showed higher species richness than maize, especially in higher altitudes. Maize was characterized by narrow weed spectrum with few predominating species. The tested hypothesis was confirmed and a statistically significant effect of altitude on the occurrence of thermophilic weed species has been found.
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Influence of bioeffector Trianum on the soil phosphorus availability and P uptake by maize
Vukliševič, Zdeněk ; Kulhánek, Martin (advisor) ; Sedlář, Ondřej (referee)
Phosphorus is likely to become, in the near future, a critical element in plant nutrition. The main reason is primarily limited resources of P for fertilizer production. Therefore, it is necessary to look for a long term solution. One option is to use P -containing waste, such as sewage sludge, digestate or ashes. Another option arises from the fact that approximately 90% of P in soil is found in non-bioavailable forms. Mobilization of these forms could secure enough P for plat growth in the long term horizon. So-called bioeffectors are developed for this purpose; to promote the accessibility of nutrients for plants. However, it is evident, that the application of bioeffectors alone could lead to a gradual outflow of P from soils. Therefore most favourable appears application of bioeffectors in combination with various phosphatic fertilizers or waste materials. Especially rock phosphates, ash and digestate contain significant amounts of less bioavailable P forms. The joint application of these fertilizers and bioeffectors should lead to more efficient utilization of P, and thus reduce the input of fertilizer into the soil.
The aim of this study was to verify influence of bioeffector Trianum (Trichoderma harzianum, strain OMG 08) to yield of above-ground biomass, plant height and consumption of P by maize plants from the low P soils. Our aim was also to verify mobilization of P from less available forms in different fertilizers through due to the bioeffector influence and impact assessment to consumption of other limiting nutrients (sulfur and zinc) by maize plants.
Along with the unfertilized control variant the bioeffectors were also applied in combination with following fertilizers: straw ash, wood ash, sewage sludge, torrefied sewage sludge, solid fraction of the digestate, minced phosphate). As an additional control bioeffector was selected a biological fertilizer OD containing microorganism Penicillium bilalii.
The evaluated results did not shown any significant influence of bioeffector to yield of above-ground biomass, plant height or phosphorus mobilization. Statistically significant effects were obtained only by combinations of fertilizers and bioeffector in the case of uptake and content of sulfur. Statistically significant differences were proved within studied variants of fertilization without regards to bioeffector applied.
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Schopnost kokrhele menšího (Rhinanthus minor L.) parazitovat na vybraných druzích trav a snížit produkci jejich nadzemní biomasy
Křeček, Tomáš
In past, yelow rattle (Rhinanthus minor) was considered as a weed in grasslands due to grass yields reduction and rapid loss of its forage quality. But today it is valued for its ability to reduce the competitiveness of aggressive species of grasses, allowing restoration of species-rich grasslands. In dry and warm conditions in southern Moravia there was tested the suitability of different grasses to serve as host of Rhinanthus minor. The impact of irrigation was also assessed in drought conditions during spring growth on the production of aboveground biomass hemiparasitic plants and their hosts. The last part of the experiment was a test hydrophobicity and infiltration capacity of soils. Field experiment was established in Žabčice experimental station of Mendel University in Brno. To determine the ability of Rhinanthus minor to parasite on various grasses red fescue, Kentucky bluegrass, perennial ryegrass and tall fescue were chosen. Irrigation significantly increased the number of plants and biomass of Rhinanthus. The largest nu-mber of plants and the highest biomass of Rhinanthus minor was found on irrigated plots with tall fescue. On the other hand, the smallest number of plants and the biomass were on the plots with red fescue. These differences are probably related to the ability of the host plant to cope with adverse environmental conditions. The experiment results in finding that red fescue is not a suitable host for Rhi-nanthus minor in dry and warm conditions in southern Moravia. On the contrary, it se-ems that the perfect hosts are deeply rooted tall fescue and clonal (rhizomatous) smooth stalked meadow grass.
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Physical processes leading to failure and entrainment of slightly cohesive material initiated by groundwater seepage
Světlík, Daniel ; Bruthans, Jiří (advisor) ; Mašín, David (referee)
Relatively recently the geomorphologists have realized that beside the overland flow the groundwater flow emerging from porous rock or soil can under specific conditions cause erosion of that material and create land forms. The goal of this theses is to demonstrate the importance of seepage erosion, which on many places on the Earth contributes to the landscape development, and also to describe the physical nature of the erosion processes acting on slightly cohesive material leading to it's entrainment or failure. Special attention is paid to erosion influence of groundwater on stability of streambanks, where in case of suitable hydraulic and geomechanical properties of the material, a perched water table can be developed leading to lateral seepage through a conductive layer and undercutting the bank face.
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The Problem of Nicotinism at Primary Schools in České Budějovice Region
TVAROHOVÁ, Zdeňka
Abstract More and more young people, also children, are using tobacco products. It is serious patological phenomenon which can effect not only person using the tobacco products, but also the whole society. Using tobacco products causes serious health hazard and diseases, which are usually irreversible. Smoking tobacco is very spread in Czech republic as much as drinking alcohol. Both these phenomenons are tolerated by the society. Society has a big influence on everyone of us and it is very important to prepare healthy environment for curious and inexperienced children. The target of my work is to map the age and motivation factors of the first use of tobacco products, frequency and range of using and attitude towards the smoking. I also target on prevention in schools. Based on the studied materials I stated hypothesis concerning the age of using, realised prevention in schools and ratio between male and female smokers. I used technique of anonymous inquiries. Inquiry was checked by pre-research on which I examined functionality and fullness of the inquiry. Hypothesis {\clqq}I assume that more than half of under age (younger than 15 years) used tobacco products`` was confirmed by the answers in my inquiry. Hypothesis ``I assume that male smokers are more often{\crqq} wasn{\crq}t confirmed. There is 3% more smoking females than males. Hypothesis {\clqq}I assume that realised prevention in school was after the first experience with tobacco and is there for useless`` was also confirmed. It can be presumed of the fact that 17% of the informants didn{\crq}t answer the question, 3% answered ``I don{\crq}t know{\crqq} and 8% answered that they never received any warnings of health riscs in the school. Informants were chosen from two primary schools. Inquiried were total of 203 informants from 6th to 9th grades from ZŠ Kubatova in České Budějovice (91 pupils) and ZŠ Trhové Sviny (112 pupils). Age of the first experience with tobacco products is getting lower, because this inquiry confirmed that average age of the first experience was at 10,9 year of children{\crq}s age. That is why I maintain how important is to prepare complex view of nikotinism problem on primary schools.
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Pile Foundations - Energy Piles
Hoza, Martin ; Leiter, Augustin (referee) ; Glisníková, Věra (advisor)
At a time when ecology and renewable energy sources come to the fore, the use of geothermal energy appears to be one of the suitable alternatives. The aim of this paper is to explain the function of ground source heat pumps, to mention factors affecting the efficiency of the system and discuss the technology of energy piles realization. This paper also focuses at risks associated with the soil temperature influencing and shows examples of realization.
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