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Optimalization in allocation drivers at bus service
Sokol, Petr ; Štěpán, Josef (referee) ; Bartušek, Bohumír (advisor)
The thesis is focused on suggesting an algorithm for planning of optimal assignment drivers and vehicles to scheme of expeditions. When we make the assignment, we aspire to minimize the total transportation costs. By the same mail we push for well-balanced assignment, with respect to utilization of drivers and vehicles . The structure of the planning problem there is describing by making out of a wide linear model, whose parts are algebraic formulations of restrictions, which one must in traffic abide. In this model we can see binary and real variables that mean we draw up a model of mixed integer programming. We can say, that the integer programming is in general more complicated, then integer programming. We used optimization software named GAMS for solution this problem. The software uses Branch and Bound algorithm for the integer number problems. We draw up a program in GAMS, which is able to set an optimal pian for assignment drivers and vehicles to expeditions. A part of this work is couple of exemplary tasks, with their solution.
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Expression of cholinergic gene locus in a mouse model of Alzheimer's disease
Zimčík, Pavel
(anglický jazyk) The most common senile dementia, Alzheimer disease (AD), is characterized by a decline of memory and high cognitive functions. Typical post-mortem brain lesions are extracellular amyloid deposits, intracellular neurofibrilary tangles and ruined cholinergic and other neurotransmitters systems. Connection between damaged central cholinergic system and beta-amyloid accumulation remains obscure. We examined parietal cortex of young adult (7- month-old) female APPswe/PS1dE9 double transgenic mice which develope beta-amyloid fragments at high rate. Cholinergic synapses of these mice demonstrate functional presynaptic (stimulated acetylcholine release) as well as postsynaptic (muscarinic receptor-induced Gprotein activation) deficits and reduction of cholinergic markers. The mRNA levels of choline acetyltransferase, vesicular acetylcholine transporter and M1 to M4 subtypes of muscarinic receptors were determined in transgenic and littermate controls using qPCR. Obtained experimental data does not show any changes in measured mRNA levels. These observations indicate that reduction of cholinergic synaptic markers and function is due to posttranscriptional events.
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Analysis of precious metals and diamonds
Suchánková, Veronika ; Veselá, Jitka (advisor) ; Havlíček, David (referee)
The main intention of this thesis is the analysis of the factors that influence the precious metals market according to the selected methodology. The secondary intention is the consideration of the posibility to include the commodities traded on the precious metals market in the portfolio of investments. The introductory chapter deals with the listing of the commodities, the most important commodity exchanges and derivatives. The second chapter individually describes the precious metals. The first subsection of the second chapter analyzes the supply and demand for the individual metals. The following subsections focus on the factors that influence the price of the precious metals in history and in present time. The analytical part, which concludes this chapter includes the calculations of correlation coefficients, average growth coefficient and standard deviation of the factors that influence the precious metals. The last chapter of this thesis is dedicated to diamonds and is divided to two major subsections. The first subsection describes the history of the most significant diamonds, the characteristics of diamonds, the types of the deposits and the major producers of diamonds. The second subsection analyzes the prices of natural and synthetic diamonds and the development of profit of the selected company in terms of time. The last chapter deals with investments in diamonds.
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Alternative fuels for transport
Běláčková, Adéla ; Dvořák, Antonín (advisor) ; Hadrabová, Alena (referee)
The thesis Alternative fuels for transport is dealing with the topic of economic competitiveness and environmental advantages of alternative fuels in comparison to classical oil fuels in transport. First, the main transport related problems are discussed in detail, including the dependency on oil, emissions from transport and their impact on human health and the environment. Then, the different types of alternative fuels are presented, including the legal framework, possibility of tax exemption and subsidy financing. The comparison of emissions of alternative and classical fuels follows the logic of the whole life cycle of a fuel, using the Well-to-Wheel analysis as method. Emissions of greenhouse gases and emissions of pollutants of local importance are observed. The cost comparison is based on experience in public bus transport in the Czech Republic. Fixed, variable and total costs are compared for classical diesel, biodiesel, natural gas, LPG, hydrogen and an electric vehicle. The purpose of the study is to decide which of the alternative fuels represents a cost competitive option in comparison to classical diesel and also provides a reduction in total emissions. The results of the study are designed to help Krkonošské Metro Association to choose a suitable alternative fuel for a project in rail transport.
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Design a AHU unit with respect to the heat recovery system
Otava, Jiří ; Blasinski, Petr (referee) ; Rubina, Aleš (advisor)
This diploma thesis is focused on problems of heat exchangers. There are two main objectives. The first objective is based on long-term measuring of enthalpy heat exchanger, processing of measured data and comparison of result with manufacturer's results. The second objective is design of variant solutions for two types of heat exchanger of air conditioning unit of selected shop. For variant without moisture transportation was selected cross flow exchangers. Thanks to knowledge from long-term measurement, was selected enthalpy heat exchanger for variant with moisture transportation. Chosen variants were compared with emphasis on heat and moisture exchange efficiency with requirements on Ecodesign.
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Sediment deposition in reservoir of Nové Heřminovy dam
Kammermayer, Jan ; Šedivý, Jiří (referee) ; Zachoval, Zbyněk (advisor)
The thesis deals with silting of water reservoir Nové Heřminovy. There's describe design of artificial traffic and evaluate its effectiveness. To determine the flow of sediment into the reservoir with use a partially calibrated one-dimensional numerical model of sediment transport with deformation of bed is made in software HEC-RAS. Silting reservoirs is assessment with two methods, the results are compared and describes their limitations. Reservoirs silting evaluates through volume changes in reservoir storage in time.
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Transport of proteins into secondary plastids
Vanclová, Anna ; Hampl, Vladimír (advisor) ; Doležal, Pavel (referee)
Secondary plastids can be found in many unrelated groups of organisms among three supergroups - Excavata, Rhizaria and Chromista. Primary plastids in contrast are unique and defining feature of the Archaeplastida supergroup. Secondary plastids have arisen through several independent endosymbiotic events, in which engulfment of an eukaryotic cell containing primary plastid occured and its reduction and integration by transfering bulk of their genome into host nucleus occured. Crucial difference between primary and secondary plastids is number of surrounding membranes which need to be crossed by nucleus-encoded proteins which is higher in secondary plastids. Mechanisms of protein transport into secondary plastids are therefore more complicated and more molecules and signals partake in these mechanisms. Diversity of secondary plastid-bearing organisms notably contrasts with the fact that the transport pathways and molecules they use often share mechanism of function and origin. These similarities probably reflect general principles of cell biology and not phylogeny.
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Deposition of Titania from Solution by Hybrid Water-Stabilized Plasma Torch
Mušálek, Radek ; Medřický, Jan ; Tesař, Tomáš ; Kotlan, Jiří ; Lukáč, František
Thermal spraying with liquid feedstock presents a novel route for deposition of functional coatings. In this study, possibility of preparation of titania coatings from solution by hybrid water stabilized plasma torch is presented. Coatings were prepared from solution of titanium isopropoxide Ti[OCH(CH3)2]4 in anhydrous ethanol. Fragmentation of feedstock stream in the plasma jet was monitored by shadowgraphy. Deposition was carried out on steel samples mounted to the cooled rotating carousel. Cross-sectional images from SEM microscope showed successful formation of the deposit with dual morphology consisting of fine feather-like features combined with bigger droplets. X-ray diffraction revealed formation of nanometric rutile crystallites.
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The bridge among buildings
Chaloupka, Petr ; Ing.Karel Sýkora (referee) ; Puchner, Josef (advisor)
This master's thesis deals with the designing of the appropriate supporting steel structure footbridge for pedestrians. The footbridge is used to connect two separate buildings (buildings D and Z at the Faculty of Civil Engineering Brno University of Technology). Four variants have been designed about solutions supporting steel structure. The final variant was prepared in detail and was carried out static assessment of the individual elements and selected details. The main supporting structure of this variant are two trusses. Diagonals of these trusses are designed linkage system of Macalloy 460. Bridge deck is designed of composite steel a concrete board with crossbars. The footbridge is designed as simple beam with an overhanging end. Length span is 34.8 m, length overhanging ends is 5.8 meters. The total length of the footbridge is 40.6 meters. Width of footbridge is 2.8 meters. Free width is 2 meters. In the cross point with the axis of local road is height of footbridge above ground 4.43 meters. Next to the building Z, there is a footbridge stored on a concrete support, near the building D, the footbridge is stored on a steel frame of support. The footbridge is deposited on elastomeric bearings. The footbridge is being protected from the weather. The sheating of the building is designed by Wictec 60 system. The master's thesis also contains drawing documentation of the proposed solution.
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