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Isosters of transkarbams, synthesis, properties and biological activity
Holas, Tomáš ; Hrabálek, Alexandr (advisor) ; Sedlák, Miloš (referee) ; Beneš, Luděk (referee)
1. SUMMARY The major aim of this dissertation was to synthesize and test isosteric analogs of T12. On the whole, 76 new compounds were prepared which have not previously been published. 28 compounds were tested as the transdermal permeation enhancers. Structure of these synthesized compounds was confirmed by FTIR, 1 H NMR and 13 C NMR analysis. Purity of the carbamate salts was verified by CHN analysis. With respect to the results, financial and time demandingness, permeation-enhancing activity was measured only on selected compounds. More than 400 permeation experiments were performed, more than 3000 HPLC chromatograms were analysed. To sum up, the permeation studies have shown that there is the relationship between structure and action of the studied compounds in the middle-lipophilic donor medium. Permeation-enhancing activity from the 60% propyleneglycol donor medium is in the following order: ester carbonate ketone ≥ amide = carbamate = alkane. Furthermore, there have been found another arguments confirming proposed mechanism of action of T12 - CO2 release in stratum corneum.
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Reconciliation of knowledge on primary school children traffic injury prevention
ŠESTÁK, Milan
Porovnání znalostí o prevenci dopravních úrazů u dětí na základních školách. Reconciliation of knowledge on primary school children traffic injury prevention Injuries of children remain to be general health-social problem. Children may get injured as pedestrians, cyclists or as car passengers. Traumatic situations have impact on families and relatives of victims, who need help. My work deals with issues which I face daily in my work environment. I have been working for Czech traffic police for 24 years. I am interested in traffic education, including prevention and education of school children. This was also subject of my bachelor work. My diploma work is focused on reconciliations of knowledge on primary school children traffic injury prevention in South Bohemia and analysis of preventive activities implementation (primary injury prevention in the area of traffic injuries) in monitored elementary schools. The reason why I have chosen this subject is that I have dealt with similar subject already in my bachelor work and I often face traffic injuries in my work life. That includes injuries of both adults and children. Quantitative research has been applied for the purpose of work objectives identification. In order to verify my hypothesis I have chosen data collection technique using questionnaire. Resulting answers of children have been assessed from 338 questionnaires which is an assessment allowing sample. Results for teachers were assessed from the sample of 11 questionnaires.Results have been shown in the individual charts which may be compared. Analysis of preventive activities implementation (primary injury prevention in the area of traffic injuries) in the monitored primary school form separate part of my work. Results of my work should contribute to better informedness of teachers, parents and children, improved education of teachers, parents and children as well as other involved parties. I put emphasis on deepening knowledge of children in areas unknown to them. Considering results of my research it is therefore important to keep improving informedness in the area of traffic injury prevention within the given age group. I know already now what I will focus on during my presentations, discussions and events associated with preventive traffic programs organized not only by the Czech Police, but also by other organizations. It is important to make all parts of our community involved in injury prevention.
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Duty od Care of Members of Statutory Bodies in Capital Business Companies and its Relation to Internal Compliance Programs
Andreisová, Lucie ; Dědič, Jan (advisor) ; Boháček, Martin (referee) ; Lasák, Jan (referee)
The purpose of this dissertation is to provide its readers with a detailed and comprehensive look at the institute of duty of care, business judgment rule and related civil and partly also criminal liability of members of (not only) statutory bodies of capital business companies, and in this respect also to introduce an internal compliance program as one of the main instruments of good and effective corporate governance. The main objective of this dissertation is therefore to verify or refute the hypothesis whether, and if so in what particular form, can an internal compliance program be seen as an institute helping members of statutory bodies of capital business companies in fulfilling specific requirements and obligations of their duty to carry out the statutory function with due (managerial) care. The existence (implementation) of an internal compliance program is quite commonly connected with so called regulated markets and also with individual business corporations whose ownership structure extends the boundaries of the Czech Republic (typically British or American business corporations seated in the Czech Republic). But what about a wide neutral zone of Czech business corporations, i.e. especially small and medium-sized capital business companies? Shall these implement an internal compliance program as well? And, if so, on what grounds and with what benefits?
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Cooperation model for architecture and integration areas
Rubeš, Milan ; Jandoš, Jaroslav (advisor) ; Havlíček, Zdeněk (referee) ; Zuzák, František (referee)
In today's economics, medium and large-size companies are trying to gain a competitive advantage from specialization and centralization of supporting services. This trend affects also areas of enterprise architecture and integration where they establish particular teams to support the disciplines in regular manner. Despite a lot of research activities oriented towards these topics, there are only a few focusing on organizational aspects and cooperation between enterprise architecture and integration teams. As the companies are on different levels of the maturity in both areas and focusing on different aspects of architecture and integration, there is no simple solution that could provide detailed guidelines for establishing the right cooperation approach. Goal of this dissertation is to propose a cooperation model for architecture and integration teams that should make cooperation between such teams more efficient. Integral part of the dissertation is to verify the model in real environment. The model is built on top of integration activities performed either in enterprise architecture or integration teams or both. These activities are categorized into particular integration areas and relations are identified between integration areas and architecture areas defined according to TOGAF architecture framework. The resulting model is then being used to depict various kind of cooperation between architecture and integration teams based on the companys' integration goals. Verification of the model is performed in financial enterprise in two cases and confirms the benefits of the model.
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Performance management – effective motivation and development of employees
Jelínková, Petra ; Němec, Otakar (advisor) ; Kleibl, Jiří (referee) ; Folwarczná, Ivana (referee)
This dissertation thesis is focused on employee job performance motivation and development. The theoretical part of this thesis was analysed current scientific knowledge in the field of human resources management, performance management and motivation which was further verified practically by a questionnaire survey in a particular company, which is a local branch of an international organization. The questionnaire survey was designed to allow comparison with the market. Based on these findings have been identified weaknesses that were found in practice while applying the concept of performance management. Analysis of survey and available resources were the basis for the creation of a new model of motivating approach to staff development within the application of the concept of performance management. This model has been applied in practice, particularly in the company, which carried out a questionnaire survey. By mentioned above, the objective of the dissertation thesis was filled.
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The effectiveness of monetary policy during the crisis
Vávra, Stanislav ; Babin, Jan (advisor) ; Rod, Aleš (referee)
This thesis aims to empirically verify and analyze the effectiveness of monetary policy during the crisis, with a focus on inflation. It also shows the evolution of inflation and the volume of loans to non-financial corporations and households in the Czech Republic and Germany in each year. Empirical testing is set on the basis of correlation analysis. It explores the dependence between principal central bank interest rates, inflation and volume of loans to non-financial corporations and households in the Czech Republic and Germany. The results of the testing are much different in each of the countries. While in the Czech Republic, there was some effectiveness of monetary policy detected, it wasn't confirmed at all in case of Germany.
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The issue of cycle routs at the Beskydy mountains
Glogar, Čestmír ; Šafránek, Jiří (advisor) ; Břuska, Jan (referee)
Title The issue of cycle Routsou at the Beskydy mountains. The aim of the work The aim is to practically verify markings, condition, quality and passability routes due the surface and contour path and create a clear summary of the bike in the designated area Beskyd. A method Thesis is worked out by comparing the available research Materials about biking in Beskydy with a field survey of the territory. results The result of this work is the finding that the marking of cycling routes in the area Beskydy is very decent level. Furthermore, managed to create a clear summary of the bike, from which cyclist can choose the route with respect to its shape, type of wheels and a popular destination road surface. Keywords Beskydy, cycling, biking, bike trail, Powered by TCPDF (www.tcpdf.org)
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Comparison of Autocratic and Democratic Style of Leading While Taking Account Their Influence on the Working Environment
Švarcová, Monika ; Havrdová, Zuzana (advisor) ; Juřička, Radomír (referee)
The aim of the thesis is to distinguish the leadership of two different managers with different styles of managerial skills and evaluate the whole process and consequences in case of management change in certain nursing facilities. By means of quantitative research the thesis further overviews the fact that leading skill is a manifold of substantial factors that importantly influence the interpersonal relations, working standard, motivation and working climate. The provided service quality is evaluated as well. The validity of research, theoretical part of the thesis was verified in general practice. Important learning was the fact that leading skill is a manifold of substantial factors that importantly influence the leadership standard, staff motivation and their effectivity, working climate and interpersonal relations as well.
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A laparoscopic approach to the prevention of complications in female endometrial cancer
Demo, Pavel ; Kučera, Eduard (advisor)
In this thesis I present a retrospective analytical study , which evaluates the results laparoscopically assisted vaginal hysterectomy (LAVH ) in the treatment of endometrial cancer and compare them with the results of similar studies in the professional press . This work will also basis for extensive retrospective study that will compare laparoscopically assisted vaginal hysterectomy and abdominal open surgical technique in the treatment of endometrial cancer . The aim of the thesis is to verify : Whether the laparoscopic approach yields fewer complications than the abdominal approach . What is the length of hospitalization using laparoscopic techniques . Compare the length of laparoscopic surgery of the file with a length of operations other workplaces. At the beginning of the thesis is devoted to the issue of endometrial cancer laparoscopic operations generally focus on a laparoscopically assisted vaginal hysterectomy (LAVH ) and its use in the treatment of endometrial cancer . Information for creating a group of patients who underwent LAVH in the diagnosis endometrial cancer , I have gained from operating books of the year 2001 - 2005 from the Institute for Mother and Child in Prague - Podolí. I also used a computerized database archive , also courtesy of Institute for the Care of Mother and Child...
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Use of microwave technique for the assessment of hydration status in dialysis patient
Brožíková, Zuzana ; Slovák, Petr (referee) ; Lopot, František (advisor)
The task of this work was to evaluate the possibility of using microwave sensors to assess hydration status in dialysis patients. For this purpose it was necessary to evaluate existing methods of monitoring fluid balance and determining the optimal postdialysis weight (dry weight) in dialysis patients, become acquainted with contemporary equipment techniques for monitoring blood volume and study the possibilities of microwave technology for monitoring of changes in tissue hydration. To confirm the usefulness of this original method was performed in GHz measurements in vivo, which was divided into three parts - measuring a group of healthy subjects, measuring a group of dialysis patients during hemodialysis (HD) and additional measurements. When the sensor were applicated on the forearm changes in resonant frequency, quality factor or Q-factor and the amplitude changes were observed. In healthy subjects assessed the effects of sex, age and BMI (body mass index). In dialysis patients were evaluated correlations of observed GHz parameters changes compared with data obtained by ultrafiltration indicated by dialysis machine. Both groups were supplemented by bioimpedance spectroscopic examination. Additional measurements was verifying factors that could affect the reproducibility and the resulting value (the...
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