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Mechanizmy vzniku rezistence vůči platinovým cytostatikům
Bouška, Petr ; Štaud, František (referee) ; Čečková, Martina (advisor)
1. Abstract Although the first platinum drug cisplatin was initially described in 1845, its biological activity was discovered more than 100 years later. Since then are cisplatin and its clinically used analogues carboplatin and oxaliplatin in widespread use for the treatment of variety of human cancers, including ovarian, cervical, head and neck tumors, non-small cell lung, breast, colon, gastric and renal cell carcinoma, sarcoma and relapsed lymphoma. However, the treatment is often accompanied by severe side effects of which nephrotoxicity, peripheral neurotoxicity and myelosuppression are the most serious. Another important obstacle in their clinical use is drug resistance. This thesis evaluates possible mechanisms of the development of platinum drugs resistance. There is a variety of them and they include (i) diminished accumulation of platinum drugs affected by influx transporters (Aquaporin 9, CTR1, OCT1, OCT2) and by efflux transporters (ATP7A, ATP7B,ABCG2); (ii) increased detoxification of drug by thiols glutathione and metallothionein; (iii) improved repair of nuclear lesions affected by NER, MMR, Homologous recombination, and enhanced tolerance to nuclear lesions caused by Replicative bypass, inhibition of pro-apoptic factors (including caspase-3, -8, Fas and other), or by overexpression of...
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Importance of forest continuity and fragmentation according to beetles as an indicating taxonomic group
Loskotová, Tereza ; Treml, Václav (referee) ; Romportl, Dušan (advisor)
Importance of forest continuity and fragmentation according to beetles as an indicating taxonomic group Abstract Old-growth forests can provide suitable habitats for certain organisms which can't live in another type of environment. These organisms can be used as bioindicators of old-growth forests. Spatial organization of forests affects spatial distribution and population abundance of these organisms. Fragmentation process can negatively influence populations of forest organisms. In particular, the aim of this work was to locate areas with forest continuity within the area of interest and to characterize their spatial arrangement. Long-term continuity of forests was identified using historical maps. Spatial distribution of forests is not equal. In the northern and north-eastern part of the area, there is a large forest complex while in the southern and south-western part of the area, there is lot of forest fragments with surrounding of agriculture fields. Next target was to select beetle group with potential bioindicators of forest continuity. Many beetle species live in forests and the group fulfills requirements for indicating groups. Saproxylic beetles were chosen as a crucial group for a subsequent study. Keywords: continuity, fragmentation, indicator, landscape structure, beetles
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Social networks to support competitiveness in companies
Rumplíková, Blanka ; Molnár, Zdeněk (advisor) ; Měsíček, Libor (referee)
This thesis focuses on the issue of social networks. Social networks are one of the many types of social media, which are defined in the introduction of this thesis and described their characteristics. The thesis focuses on the options of two social networks in marketing and on the internet marketing in general. There are three criteria for the use of social net-works in companies -- sales promotion, publicity and communication. They are first de-scribed theoretically, analyzed in the environment of a particular company, the company Student Agency, and ultimately within these criteria suggested solutions to improve the use of social networks in the company. The aim of thesis is to define the possibilities of using social networks in companies to promote competitiveness, describe the options on real company and suggest possible improvements.
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Categorial pastorship for politicians
Kasal, Jan ; Kuźniar, Mariusz (advisor) ; Opatrný, Aleš (referee)
Název diplomové práce: KATEGORIÁLNÍ PASTORACE PRO POLITIKY Autor: Jan KASAL 2010 RESUMÉ Tato diplomová práce si klade za cíl odpovědět na dvě základní otázky: 1) Jsou křesťané působící v politice a ve veřejných funkcích specifickou kategorií Božího lidu, pro kterou by bylo užitečné vytvořit nějaký speciální typ kategoriální pastorace? 2) V případě, že by této skupině křesťanů byla kategoriální pastorace k užitku, jaké pastorační strategie by měly být použity? Odpověď na první otázku lze nalézt v úvodních kapitolách práce. Na několika vybraných historických úsecích je dokumentováno, jak se církev jako instituce postupně emancipovala od mocenských státních struktur (byť leckdy tomu bylo i naopak). Dále je popsána a zdokumentována dlouhá cesta zvyšování nároků na laiky se zdůrazněním jejich nyní už nezastupitelného místa nositelů a hlasatelů sociálního učení církve. Řada oficiálních církevních dokumentů 19., 20. i tohoto století úlohu laiků jako světských představitelů křesťanského učení nejen popisují, ale současně všechny, kteří se odhodlali na cestu politiky vstoupit, tyto dokumenty povzbuzují a dávají jim někdy rámcové, jindy konkrétnější mantinely a obrysy pro jejich veřejné působení. Křesťané v politice se tak i na základě těchto dokumentů stávají autentickými nositeli a hlasateli evangelia. Jejich...
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Implementation of principles and philosophy of CRM in selected company.
Rokošný, Lukáš ; Koliš, Karel (advisor) ; Zákutný, Juraj (referee)
Bachelor thesis is concerned with the analysis of internal processes at a particular company, and the process itself in terms of the contract. It describes the current position on the market and compares it with the competitors. The practical part is dealing with the elements of customers' behavior and identifies points for improvement. At the same time it is proposing ways to improve the process of contract, based on this it creates a basis for the implementation philosophy of CRM in the company. The theoretical part is dedicated to the definition of basic concepts of CRM and simple principles of CRM strategies. Likewise it is seeking beneficial customer relationships, their development and maintanance. Also the value that an enterprise can create for the customer is described, and what can be obtained based on it.
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Immovables insurance
Růžková, Lucie ; Ducháčková, Eva (advisor)
The paper deals with the immovables insurance. This insurance line up non-life insurance. In the paper there is describe general one theory. The text focuses on legal regulations. Many facts are illustrated through tables and charts for clarity. Futher parts deal with concrete examples of Česká insurance company, Kooperativa and Allianz insurance company.
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The burial structures of the chosen tribes of the North Africa within a period from 4th century B.C. to 5th century A.D.
Kramerová, Martina ; Stančo, Ladislav (advisor) ; Bouzek, Jan (referee)
This diploma thesis examines the burial architecture of selected Berber tribes of Northern Africa, namely the Garamantian and Numidian ones, within a period from 4th century B. C. to 5th century A. D. First, the Garamantian tribe and its history is introduced. Afterwards I focus on garamantian burial customes and architecture. Further I describe each types of tombs and individual monuments , thein proportions and decoration. The other important part is devoted to the Numidian tribe. Again, its history, types of burial structures and individual important monuments are described in detail. In this diploma thesis there is also a mention about tribes and monuments which influenced funeral structures and architecture of tribes in North Africa and also about buildings which were the models for these tombs. Keywords architecture, burial customs, Berbers, north Africa, tombs
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Proofs for the Existence of God in Descartes' Principles of Philosophy
Křížek, Pavel ; Svoboda, David (advisor) ; Sousedík, Prokop (referee)
Proofs for the Existence of God in Descartes' Principles of Philosophy Summary In present bachelor's degree work, a short review of Descartes' arguments for the God's existence is given. After a brief explanation of the structure of Descartes' system and of the basic philosophical terms used by Descartes in his works, the fundamental role of arguments for the God's existence in developing of Descartes' system is described. This introduction makes the reader familiar with the subject of the present work; the individual versions of Descartes' arguments are presented in a concise form. Then the Priniciples' version of the arguments is shown in comparison with other versions, first of all, with that ones from Meditations. The ontological argument is attended and it's simplicity is noted, particularly in Principles. It is shown a close connection between Descartes and the scholastic tradition consisting in Descartes's using and developing of a unique, sophisticated solution of the traditional problem of relation between essence and existence of finite beings (the theory of rational distinction), extended by Descartes to the nonfinite substance as well. The effectiveness of this version of the ontological argument makes it, at least partly, resistant to a whole set of the most common objections including the...
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Comparison of first and second generation of ANIC
Urazov, Maxim ; Adamcová, Lenka (advisor) ; Němečková, Tereza (referee)
Geographical, demographical, political and economic comparison of both generation of ANIC. Economic comparison is divided in to part. First part analyze economic situation at the end of previous millennium and the second part represent situation at the new millennium. In conclusion, we can see that ANIC I and ANIC II are heterogenous countries and some of them do not fulfil the condition of integration to the group of ANIC.
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