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Life behind courtain. History of the director of theatre company Pavel Švanda ze Semčic (1825-1891) and his wife actress Eliška Pešková (1832 - 1895)
MRÁZKOVÁ, Michaela
The dissertation captures the life and work of theatre-involved wedded couple Pavel ze Semcis and his wife Eliska Peskova. Based on little-known sources, it reconstructs their position within the Czech culture of the second half of 19th century. The dissertation consist of two parts. The first presents the fate of Svanda{\crq}s family, with historic-cultural map of destinations of their theatre company. Major emphasis is laid on Svanda{\crq}s work in Plzen, Smichov and Prague arenas. Attention is also paid to the course and day to day running of individual destinations; a representative example is the reconstruction in its entirety of the destination in Mlada Boleslav. The first part is concluded by contemporary appreciation of importance of Svanda and his wife and the evolution of this recognition by future generations. The second part of the dissertation describes the administrative function of the director of theatre company, and is looking for the main criteria of its prosperity. It answers questions of how theatre talents were discovered, how theatre contracts were made and by what factors they were determined, what was the level of intervention of censorship in the final form of the company{\crq}s shows. Advertisement and the appearance of theatre posters have also been important in determining the success. The thesis does not overlook the work of people taking care of costumes and scenes. In conclusion is once again summarized the contemporary critical reflection of all the factors mentioned above. From both parts, consequently, rises the specific form of the theatre work of Svanda and his wife, in the context of comparable theatre companies of second half of 19th century.
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Synthesis of novel cytostatic deazapurine nucleosides and pronucleotides
Perlíková, Pavla ; Hocek, Michal (advisor) ; Jindřich, Jindřich (referee) ; Hlaváč, Jan (referee)
The synthetic routes to three types of phosphate prodrugs of 6-hetaryl-7-deazapurine ribonucleosides based on palladium-catalyzed cross-coupling reactions have been developed. CycloSal- and phosphoramidate pronucleotides and octadecyl phosphates derived from 6- hetaryl-7-deazapurine ribonucleosides were screened for their in vitro cytostatic activity. It was shown that cytostatic activity of cycloSal phosphates was similar or slightly lower compared to the parent nucleosides. Significant drop of cytostatic activity was observed in phosphoramidate pronucleotides. Octadecyl phosphates were devoid of any cytostatic activity. 6-Hetaryl-7-deazapurine ribonucleosides with bulky groups in position 6 showed very strong and selective inhibition of adenosine kinase from Mycobacterium tuberculosis. 2'-Modified 6-hetaryl-7-deazapurine nucleosides: 2'-O-methylribonucleosides, arabinonucleosides and 2'- deoxy-2'-fluororibonucleosides, were prepared by multistep functional group transformations from a ribonucleoside. The synthesis of 2'-deoxy-2',2'-difluoro-erythro-pentofuranosyl nucleosides was based on a glycosylation of 6-chloro-7-deazapurine with a sugar synthon followed by palladium-catalyzed cross-coupling reaction and deprotection. Despite the low yields and laborious separation of the anomers,...
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Generating Methods in GR and Properties of the Resulting Solutions
Hruška, Jakub ; Žofka, Martin (advisor) ; Pravdová, Alena (referee) ; Gürlebeck, Norman (referee)
The use of conformal transformation as a method for generating solutions of Einstein's equations has been mainly studied in the cases where the original spacetime is vacuum. The generated spacetimes then frequently belong to the class of pp-waves. In the present work, the electrovacuum spacetimes are stud- ied, i.e the solutions of coupled Einstein's and Maxwell's equations. By using the conformal transformation, it is possible to circumvent solving the later equa- tions. This method is concretely studied for null Einstein-Maxwell fields and it turns out that the admissible spacetimes are pp-waves again. However, if the method is generalized, it is possible to enlarge the class of conformal null Einstein-Maxwell fields to a wider family of Kundt spacetimes. 1
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Elektromagnetické a teplotní pole v roztaveném hliníku míchaném v kelímkové indukční peci
Barglik, J. ; Doležel, Ivo ; Ulrych, B. ; Mach, M. ; Trutwin, D.
The paper deals with the mathematical and computer modeling of quasi-coupled electromagnetic, temperature and hydrostatic fields in molten aluminium in a typical crucible induction furnace. After the process of melting, the melt is further inductively heated to reach the casting temperature that is typically higher by about 200 C than the melting point. Then the active power of inductors is reduced to a level making possible only to keep the temperature at that value. During that time, however, more or less intensive stirring of the melt takes place because of presence of the Lorentz forces acting in melt.
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Lapped scarf joints for reconstruction of historical structures
Kunecký, Jiří ; Fajman, P. ; Hasníková, Hana ; Kuklík, P. ; Kloiber, Michal ; Sebera, V. ; Tippner, J.
This paper presents a description of the repair of timber structures using a prosthesis scarf\njoint designed for the replacement of damaged parts of beams. This new scarf joint makes use\nof the strutting effect of inclined contact faces where the forces are transmitted through\nwooden coupling elements - wooden dowels or keys. The scarf can be modified in four\nvariants according to the relevant stress and is suitable for historically valuable timber\nstructures. It meets both functional and aesthetic requirements. The designer - structural\nengineer will learn in the methods the load bearing capacity or stiffness of the beam with the\ndesigned joint, its recommended dimensions and detailed geometry. The contractor will\nappreciate the description of the execution and maintenance of the joint.
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Oligoester matrices with antimicrobial drugs III.
Lazařová, Klára ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
Klára Lazařová Diploma thesis 2008 The aim of this work was the study of the fluconazol and terbinafine release from oligoester carriers branched with various concentration of either mannitol (3M, 5M, 8M) or dipentaerythritol (3D, 5D, 8D) and plasticized with 30 % triethyl citrate (TEC). Theoretical part is occupied with drug delivery systems and the conditions of the coupling of the macromolecules with the biological substrates. The 150,0 mg matrices composed of carrier, drug of 4% and plasticizer TEC of 30% were prepared. They were put to the static dissolution test using phosphate citrate buffer pH 5,0 at 37řC. The drug release was determined spectrophotometricaly at 261 nm for Fluconazole and 283 nm for Terbinafine. Fluconazole release was the fastest from carrier 5D. The carriers 5D and 8D released the drug during three stages, after burst effect was observed constant liberation followed slowing the process. The carriers branched using mannitol released the drug depending of the concentration of the mannitol.
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Receptor for Nicotinic Acid
Suchánková, Marie ; Fendrich, Zdeněk (advisor) ; Hronek, Miloslav (referee)
Nicotinic acid belongs to the drugs with anti-hyperlipidemia effects. It lowers levels of both cholesterol and triglycerides and increases the level of HDL. The benefit features of this vitamin are accompanied with the side effects of flushing, mainly, that have very negative influence to patient compliance. Independently, T. Soga and A. Wise have discovered the G-protein-coupled receptor GPR109A (HM74A in humans, PUMA-G in mice) as the receptor for nicotinic acid. This elucidation opened the way to elucidate the molecular identification of the mechanism of nicotinic acid-induced flushing. We have done several experiments with PUMA-G double-knockout mice which lacking the PUMA- G receptor. First of all, we have established the method for monitoring the flushing response after the administration of nicotinic acid and acipimox, its derivative with similar effect on the lipid metabolism. From our results, it implied that nicotinic acid and acipimox causes flushing response via the receptor PUMA-G. Thus we could say that PUMA-G receptors are involved in both lipid- lowering mechanism and flushing-mechanism. It has been postulated that NSAIDs can diminish the occurring flush response in the patients. Our experiments with COX-1 -/- clearly showed that COX-1 is one of the crucial enzymes in the nicotinic...
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Study of resonance and threshold effects on simple two-channel model
Kocák, Jakub ; Čížek, Martin (advisor) ; Kolorenč, Přemysl (referee)
In this thesis we study simple one-dimensional two-channel scattering model where pointlike coupling between channels is provided by the delta potential. The scattering task can be completely solved analytically. The solution of the Lippmann-Schwinger equation leads to improper scattering eigenvectors, consequently to scattering S matrix elements and eigenphases. We study how the setting of parameters affects threshold and resonant behaviour (presence, position, width) and the mutual relationship between resonances and poles of the S matrix in complex k-plane. Then we apply projection- operator formalism to model with resonance and the on-shell T matrix is separated into the orthogonal, direct and resonant term. We discuss how choice of subspace of quasi-bound states effects the separation. Powered by TCPDF (www.tcpdf.org)
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