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Study of the composition and organization of cytochrome P450 system by covalent crosslinking
Koberová, Monika ; Hodek, Petr (advisor) ; Hansíková, Hana (referee)
The system of mixed function oxygenase (MFO system) participates in significant roles in the metabolism of endogenous compounds and xenobiotics. This system contains cytochrome P450, NADPH:cytochrome P450 reductase, and also there are assigned NADH: cytochrome b5 reductase and cytochrome b5. It was proved that cytochrome b5 can stimulate or inhibit cytochrome P450 (CYP)-dependent reactions and even change the ratio of resulting metabolites. The mechanism of cytochrome b5 action has not been fully elucidated yet. Elucidation of protein-protein interactions in MFO system and determination of topology of this system could explain the mechanism of cyt b5 action. The covalent cross- linking technique is suitable method for identifying protein-protein interactions within the membrane. Cytochrome b5 contains 3 methionines and in 2 cases the methionines are localized in a short hydrophobic C-terminal membrane anchor. Interactions with cytochrome P450 in the membrane environment can be identified by substitution of two methionine for photoactivatable analogue of methionine (photo-methionine) and subsequent photoactivation. This work is focused on expression and isolation of photo-cytochrome b5 (photo- cyt b5), cytochrome b5 analogue with incorporated photo-methionine. Conditions for photo-methionine...
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Association of Idependent Theatres of the Czech Republic – Analysis and Description of the Current State
Bodoríková, Markéta ; KAŠPAR, David (advisor) ; PROKOP, Petr (referee)
The thesis is focused on newly established Association of Independent Theaters of the Czech Republic, officially using the abbreviation AND ČR. The aim of the thesis is to describe formation of the association, its current state, future plans and its functioning. The first part examines the term “independent professional theater” and briefly characterizes selected organizations from the Czech Republic and Europe with the potential to meet with the AND ČR in the cultural area in future. In the following parts were researched needs of independent professional scene in Prague and was described the needs analysis for the field of “independent” theater from the year 2013. The thesis describes the development of AND ČR, its activities up to current stage, organizational structure and future short-term plans. In the final part of the thesis, there is defined the management system of the association and established its possible improvements so the AND ČR would become the leading organization representing independent professional theaters in the Czech Republic.
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International Monetary Fund
Drobná, Martina ; Hrdlička, Pavel (advisor) ; Severová, Lucie (referee)
The object of this thesis is an analysis of the current role of the International Monetary Fund in the 21st century. The first part of this thesis is focused on history that led to foundation of this international organisation, the reasons for its establishment and its characterization. The second par introduces one from the most important roles of this Fund, which is providing of credit to the countries that have financial difficulties. The result of this part is an appraisal of these loans and their future development. The last part of this thesis assesses current tasks of the Internationl Monetary Fund and its role in the future.
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Employment in a state-funded institution
Brožová, Milena ; Světlíková, Daniela (advisor) ; Pikola, Pavel (referee)
This bachelor thesis is focused on employment in a state-funded institution. It is divided into a theoretical and an empirical part.
The theoretical part deals with analysis of legal regulations and their interpretation. The method of description is used in this part. The focus in legal regulations is on the problems of a state-funded institution, namely on the legal position and functioning and on management. The focus is also on labour relations, from the general definition to the conclusion of employment for a fixed period of time. The analysis of legal regulations is complemented with interpretations of authors of specialized publications.
Direct and indirect quotations are used in the text and are marked with footnotes.
The empirical part of this thesis deals with the application of legal regulations in a particular state-funded institution. The order of researched areas is in accordance with the theoretical part. The method of comparison and study of documents and internal regulations are used for analysing the data.
The primary research has shown that the legal regulations are applied without difficulty. The discovered discrepancy between the used terminology and the terminology in the Civil code does not invalidate legal documents and thus there is no need to mark it as a defect which needs to be fixed. Suggestions for discussion have been made, for which measures were proposed in the concluding part. The suggestions relate to arrangement of employment for a fixed period of time and its change to permanent contract and to allowance from the founder as a financial mean of a state-funded institution.
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Proceedings of multidisciplinary conference LASER56
Růžička, Bohdan
Conference LASER56 is a multidisciplinary and intersectoral event where different kind of specialist can meet each other. They come from various environments (private company, university, public research organization etc.). Their common denominators are laser, optics and its applications.\n\n
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Právní a zdravotně sociální aspekty činnosti OSPOD jako ustanovených opatrovníků v zámu nezletilých dětí
BORSKÁ, Jana
The Czech Republic as a signatory of the Convention on the Rights of the Child has vested the practice of state administration in the field of care for minor children to municipalities with extended powers, where the protection of the rights and legitimate interests of minor children is safeguarded by state authorities of social and legal protection of children (ASLPC hereinafter). These authorities are incorporated to the extent laid down by the Act on Social and Legal Protection of Children (Act No 359/1999 Coll., as amended). The position and roles of ASLPC and their competence and jurisdiction are also regulated by the same act. The position of workers of these authorities and its legal embodiment is equally important. Regarding professionality, there are high demands on these workers. In the Czech Republic, significant changes in legislature have been made over the past three years. These amendments have led to the strengthening of the rights of minor children and to the establishing of new tools for their protection. In connection with the adoption of new substantive regulation of family law, which is now exhaustively dealt with by the Act No 89/2012 Coll., the Civil Code, new procedural rules have been established regarding protection of rights of minor children. Such procedural legislation includes (apart from the long-existent Act No. 99/1963, the Code of Civil Procedure) the Act No 292/2013 Coll., on Special Civil Proceedings. The decision-making regarding minor children has been vested mainly by the state into the competence of courts. The courts appoint the locally relevant ASLPC as a guardian who then represents the interests of minor children. The purpose, interwoven with and derived from the first one, was to explore the opinions of selected social workers of ASLPC and of district court judges regarding the defined problems occurring during the work of ASLPCs and courts while protecting the interests of minor children. These particularly include: the use of the tool of precautionary measure; problems of different territorial jurisdiction of courts and ASLPCs; processing of complaints regarding bias in various phases of the proceedings; professional training of workers of ASLPC It is evident from the proposals of both judges and ASLPC workers that it is necessary to unify territorial jurisdiction. The courts are suggesting the priority criterion of the address where the child mainly resides. ASLPC workers suggest the official permanent residence as the prime criterion. Bias causes problems in all phases of proceedings. It is obvious that courts take differing approaches towards the solution of this problem (some courts solve the problem of bias complaints filed by the parties while other courts do not) and for ASLPC workers it is difficult to assess how to act when such complaint is raised against them. The training of ASLPC workers - workers are obliged to educate themselves and their employer is obliged to finance such training. Not all ASLPCs are able to provide training in the required extent - due to financial reasons (the average costs of education of one employee pose from 9,169 to 13,400 CZK annually and they cover approximately 6 days of training). The heavy work-load caused by insufficient numbers of ASLPC employees prevents them from completing such compulsory training. As part of the examination of the "participation of a collision guardian in court proceedings" it has been found out that irregular participation of the worker in the proceedings (absence from participation in appeals proceedings); incomplete reports (directed to courts) from surveys in families. Based on comprehensive examination of the problems of territorial jurisdiction, it was recommended that requests are independently recorded and financial compensation is provided for ASLPCs who are requested to represent minors in front of courts, to draft proposals for precautionary measures.
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Trh práce ve Zlínském kraji v roce 2013
Český statistický úřad ; Krajská správa ČSÚ ve Zlíně
Statistická data z Výběrového šetření pracovních sil ve Zlínském kraji. Přináší informace o výši a struktuře zaměstnanosti, nezaměstnanosti a ekonomicky neaktivním obyvatelstvu hodnocené podle mezinárodních definic a doporučení Mezinárodní organizace práce plně respektující definice a obsah náplně jednotlivých ukazatelů LFS (Labour Force Survey) podle požadavků Eurostatu.
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Trh práce v Praze v roce 2013
Český statistický úřad ; Krajská správa ČSÚ v hl. m. Praze
Statistická data z Výběrového šetření pracovních sil v hlavním městě Praze. Přináší informace o výši a struktuře zaměstnanosti, nezaměstnanosti a ekonomicky neaktivním obyvatelstvu hodnocené podle mezinárodních definic a doporučení Mezinárodní organizace práce plně respektující definice a obsah náplně jednotlivých ukazatelů LFS (Labour Force Survey) podle požadavků Eurostatu.
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