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Internet Criminality
Kosek, Lukáš ; Paclíková, Vlasta (referee) ; Soukup, Tomáš (advisor)
First part of this bachelor thesis deals with computer criminality in Czech Republic, as well as abroad, and focuses on the copyright infringement. It describes different ways through which criminals obtain original works for further illegal usage. Second part of this work offers possible solutions in relation to the results of my survey.
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Organization protection against malware design
Vykydal, Tomáš ; Vykydal, Miloslav (referee) ; Ondrák, Viktor (advisor)
The object of this bachelor work is to design a solution for places, where any imperfection were found.in an analysis of the current state of malware protection in a monitored company. solutions are designed for individual places, where any Result of this work is a design, which significantly increases the level of protection against malware and a description of the current situation in the problematics of malware and protection against it.
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Cryptovirology and Future of Malware
Prchal, Josef ; Říha, Zdeněk (referee) ; Cvrček, Daniel (advisor)
Malware is connected to information technology. They influence each other. The aim of this thesis is to describe various types of this software and give a brief account of its history and development. It also discusses main trends of this area and tries to foretell the future development.
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Interface for Core of Antivir Software
Valouch, Tomáš ; Granát, Jiří (referee) ; Přibyl, Jaroslav (advisor)
This master's thesis is dealing with problematics of antivirus program development. It describe evolution of viruses, antiviruses and it is trying to estimate the future development in this area of interest. There is described a design of graphic user interface for antivirus program. Finally are dicussed possible approaches for implementing the graphics user interface for forementioned antivirus program. Important part of this thesis is part which is dealing with description of implementation of mentioned user interface.
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Studies of precursor forms of SARS-CoV-2 3-CL protease
Nováková, Veronika ; Majerová, Taťána (advisor) ; Novotný, Marian (referee)
The SARS-CoV-2 virus (Severe acute respiratory syndrome coronavirus 2), the causative agent of the disease COVID-19 (coronavirus disease 2019), is an enveloped virus with a positive RNA genome. After the binding of the virus to the cell receptor and the release of the genome into the cytoplasm, the viral genome is immediately translated. It is translated into a polyprotein consisting of non-structural proteins necessary for viral replication. A part of this polyprotein is also protease 3-CL, which autocatalytically cleaves itself out from this polyprotein and further releases (and thus activates) individual proteins. Due to this key function in virus replication, 3-CL protease has become an important target for the design of specific antiviral drugs. As part of this thesis, we focused on the study of the precursor form of this protease, i.e. the protease that is still embedded in the polyprotein. The precursor form of the 3-CL protease was mimicked by attaching a 100 amino acid extramembrane C-terminal fragment of the nsp4 protein to the N-terminus of the mature form of the protease. The aim was to find out, how the sequence added to the N-terminus of the matured protease affects its enzymatic characteristics. As a part of this work, mutations of the N-terminal autoprocessing site were identified,...
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The role of IFI16 protein in viral infection
Karchňák, Jan ; Šroller, Vojtěch (advisor) ; Poláková, Ingrid (referee)
6 Abstract Viruses are obligate intracellular parasites causing a large variety of diseases. Most of their hosts, including humans, have developed particular mechanisms, which are meant to tackle such diseases. First line of defense against viruses are pattern recognition receptors. These receptors are responsible for detection of pathogen associated molecular patterns (PAMPs) and of damage associated molecular patterns (DAMPs). Inteferon γ inducible protein 16 (IFI16) is one of these receptors and is responsible for detecting alien and damaged DNA both in the nucleus and cytoplasm. Its structure contains two sequence independent DNA binding HIN domains and one PYD domain, which mediates its protein-protein interactions. In the cell it functions as a regulator of cell cycle, differentiation and plays a role in cell aging. IFI16 also triggers activation of non-specific immune response and it directly acts as a restrictive factor for many viruses. During evolution these viruses have evolved mechanism which they us to evade its imunne activity or even use it to their advantage. Keywords: IFI16, STING, DNA sensing, interferons, restriction factor, pattern recogniton receptors
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Epidemické modely s vakcinací a behaviorálními změnami
LUNGA, Petr
Compartmental models used in mathematical epidemiology were studied in order to learn about basic principles of those models and to create new ones. First two chapters are about basic SIR model, it's history and analysis. Next chapters then contain models with behavioral changes and vaccination. Models were illustrated by simulations created in the software AnyLogic.
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Biological terrorism in the context of the current global situation
TRSKOVÁ, Veronika
The diploma thesis deals with bioterrorism and current Covid-19 pandemic. The aim of the work is to analyse information and knowledge concerning bioterrorism and to analyse the level of concerns of civilians over transmission of Covid-19 in the South Bohemian Region. The work is divided into two parts. In the first theoretical part the history of biological weapons in wars and for terrorist purposes is described there. Furthermore, I am going to introduce different forms of biological weapons, for example terms such as biological warfare or biological crime. I am then going to divide b-agents, introduce bacteria, virus, fungi and their types. The general division of b-agents is followed by the description of transmission of biological agents and of the way they enter the body. Finally, we are going to focus on decontamination, combat order and model action activity of IRS units during joint intervention. The second and theoretical part defines methods and goals of the research and the results that are graphically depicted to be well arranged. The results are then described in the discussion. The main aim of the work was to analyse information and knowledge concerning bioterrorism and to analyse the level of corners of civilians from transmission of Covid-19 in the South Bohemian Region. To confirm or to disprove a given hypothesis was another part of the goal. The hypothesis reads as follows: University graduates will have statistically much higher knowledge concerning given issues than people who have not completed higher education. A questionnaire construction was used to gain the data. 212 respondents took part in the questionnaire construction. The research confirmed the hypothesis that university graduates would have statistically much higher knowledge concerning given issues than people who have not completed higher education. A measure that could deepen the knowledge in this area was offered at the end of the thesis.
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Ideas of lower secondary pupils related to the content of the curriculum focused on viruses and the ways of their transmission, expressed through a verbal description and drawing
ZÍKOVÁ, Eva
The aim of this thesis was to investigate the perceptions of primary school pupils about viruses and viral infection, both through verbal description and the use of drawings. A part of the thesis was to create a teaching unit based on critical thinking and working with text to develop pupils' constructs about viral issues. The review of the literature focuses on the definition of viruses and viral infection, and the topic of viruses in curriculum documents is introduced, complemented by an analysis of selected science textbooks. Part of the literature review is devoted to teaching methods, with an emphasis on working with text, as this method was used in the research investigation. The research itself was carried out in two primary schools through a questionnaire survey (in the form of a pretest and a posttest) combined with the implementation of the designed teaching unit. The results were then extended with information obtained from interviews with selected pupils. The results of the questionnaire survey showed that the pupils in the study sample had only a rough idea mainly about viruses and had significant difficulties in describing viral infection. After the implementation of the teaching unit, the pupils achieved better results. The teaching unit helped them better express the characteristics of the virus and the viral infection. Interviews with selected pupils confirmed these results, as it appeared that pupils were already able to describe the course of the viral infection in their own words.
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