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Analysis of antibiotic administration in prophylaxis I.
Domecký, Petr ; Malý, Josef (advisor) ; Matoulková, Petra (referee)
8 Abstract Analysis of antibiotic administration in prophylaxis I Author: Petr Domecký Tutor: PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Lucie Hauschke, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Antibiotic prophylaxis (AP) plays an important role in reduction of surgical site infection (SSI). It is the administration of an eligible antibiotic or chemotherapeutic (ATB) in a single dose, usually 30 minutes before surgery, followed by two to three doses during or after the surgery, regarding the selected ATB and the surgical procedure. The aim of this work was to analyse the AP in surgical procedures at the Masaryk Hospital in Ústí nad Labem (MNUL) in the context of the MNUL guideline (DP) and the research on available AP work. Methods: A cross-sectional observational study ran from January 2018 to March 2018 in surgical departments at MNUL. The study included patients aged ≥ 18 years who underwent surgery in a defined period (5 February 2018 to 9 February 2018) and gave their consent to the study. The practicability of the study was verified by a pilot part. Initially, a research of published studies concerning AP was carried out which provided outputs for AP establishment (PPA). Subsequently, a form for...
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Analysis of infection therapy in paediatric department I.
Trávníček, Tomáš ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Analysis of infection therapy in paediatric department I Author: Tomáš Trávníček Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: MUDr. Magdalena Rohanová, Mgr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Infections in newborns are one of the most frequent causes of death. The aim of this work was the retrospective analysis of bacterial infection in newborns with a birth weight ≤ 1500 g hospitalized in Paediatric Intensive Care Unit (ICU) and compare it with the latest findings published in the expect literature. Methods: The retrospective cross-sectional study took place in Paediatric ICU. The data were gathered between 07/29 and 08/10 2020. The study included patients in neonatal age with a birth weight ≤ 1500 g hospitalized in the Paediatric ICU in 2018 and 2019 with bacterial infection. The infection was proved by a positive cultivation, increased C-reactive protein and increased or reduced number of white blood cells. Information on the patient, infectious agent, laboratory tests, occurrence of risk factors for sepsis, selection of antibiotics, its susceptibility, dose, dosing interval and duration of administration, as well as the result of therapy were collected to a prepared form. The data were...
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Analysis of infection therapy in paediatric department I.
Trávníček, Tomáš ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Analysis of infection therapy in paediatric department I Author: Tomáš Trávníček Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: MUDr. Magdalena Rohanová, Mgr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Infections in newborns are one of the most frequent causes of death. The aim of this work was the retrospective analysis of bacterial infection in newborns with a birth weight ≤ 1500 g hospitalized in Paediatric Intensive Care Unit (ICU) and compare it with the latest findings published in the expect literature. Methods: The retrospective cross-sectional study took place in Paediatric ICU. The data were gathered between 07/29 and 08/10 2020. The study included patients in neonatal age with a birth weight ≤ 1500 g hospitalized in the Paediatric ICU in 2018 and 2019 with bacterial infection. The infection was proved by a positive cultivation, increased C-reactive protein and increased or reduced number of white blood cells. Information on the patient, infectious agent, laboratory tests, occurrence of risk factors for sepsis, selection of antibiotics, its susceptibility, dose, dosing interval and duration of administration, as well as the result of therapy were collected to a prepared form. The data were...
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Analysis of antibiotic prophylaxis in patients with osteosynthesis of proximal femur
Baťková, Anna ; Malý, Josef (advisor) ; Rejmanová, Anna (referee)
Analysis of antibiotic prophylaxis in patients with osteosynthesis of the proximal femur Author: Anna Baťková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Markéta Dlouhá Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: This work is part of the continuous monitoring of antibiotic prophylaxis (AP) at the Department of Traumatology, University Hospital. The aim was to analyze and compare key parameters of AP in osteosynthesis of pertrochanteric fractures with the previous investigation and the methodological guidelines of the University Hospital. Methods: This retrospective cross-sectional study took place from 1st April 2019 to 31st March 2020 at the Department of Traumatology at the University Hospital. AP was analyzed in 50 patients above 18 years of age and who underwent a pertrochanteric fracture of the proximal femur. Data was collected with a form, prepared in cooperation with the Department of Medical Microbiology, physicians and clinical pharmacists of the University Hospital. Information on the patient, surgery, indication of AP, selected antibiotic/chemotherapeutic (ATB) and its dose, time, route of administration, as well as the size, number and interval of administered postoperative doses and...
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Analysis of antibiotic administration in prophylaxis II.
Bobčíková, Martina ; Malý, Josef (advisor) ; Rozsívalová, Petra (referee)
Analysis of antibiotic administration in prophylaxis II Author: Martina Bobčíková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Anna Patková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: The term antibacterial prophylaxis (AP) refers to antibiotic (ATB) administration in prevention of surgical site infection (SSI). There are many factors in population which can potentially raise the risk of the incidence of SSI. The maintenance of basic rules of the AP and knowledge, influence and timely elimination of risk factors of SSI are the most important measures which can reduce a number of postoperative SSI. The aim of this study was to analyze antibiotic administration in prophylaxis in the local hospital in the Czech Republic and compare the results to well known international guidelines (ASHP-G) and latest scientific knowledge (LSK). Methods: The cross-sectional study was conducted in October 2019. During the period from 2nd to 23rd October, the data of surgeries and used AP were collected. The patients who passed the entry criteria have been included in this study. Into prepared form, patient's identification, agreement, diagnosis, surgery type, operation date, the beginning and the end of surgery,...
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Analysis of the therapy in patients with juvenile idiopathic arthritis
Procházková, Martina ; Malý, Josef (advisor) ; Rozsívalová, Petra (referee)
Abstarct Analysis of the Therapy in Patients with Juvenile Idiopathic Arthritis Author: Martina Procházková Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Methotrexate (MTX) is an effective and safe drug used for the treatment of juvenile idiopathic arthritis (JIA) and is well-known like a golden standart in the treatment of this serious illness. The aim of this study was analysis of therapy in patients with JIA focusing on MTX and faktors affecting its intolerance. Methods: The study was undertaken from January 2017 to February 2018 at the Department of Paediatrics and Adolescent Medicine, 1st Faculty of Medicine, Charles University in Prague. Patients younger than 18 years old, who have become ill with JIA for the first time or repeatedly between years 2015-2017 and were treated by MTX were included in this study. The prevalence of MTX intolerance was measured by "Methotrexate Intolerance Severity Score" questionaire every 3 months during regular rheumatological examinations. Simultaneously, medical records were reviewed. Data analysis was performed by means of descriptive statistics, correlation dependence and statistical signifikance of dependence was assessed with statistical two-choice...
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Analysis of the therapy in patients with juvenile idiopathic arthritis
Procházková, Martina ; Malý, Josef (advisor) ; Rozsívalová, Petra (referee)
Abstarct Analysis of the Therapy in Patients with Juvenile Idiopathic Arthritis Author: Martina Procházková Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Methotrexate (MTX) is an effective and safe drug used for the treatment of juvenile idiopathic arthritis (JIA) and is well-known like a golden standart in the treatment of this serious illness. The aim of this study was analysis of therapy in patients with JIA focusing on MTX and faktors affecting its intolerance. Methods: The study was undertaken from January 2017 to February 2018 at the Department of Paediatrics and Adolescent Medicine, 1st Faculty of Medicine, Charles University in Prague. Patients younger than 18 years old, who have become ill with JIA for the first time or repeatedly between years 2015-2017 and were treated by MTX were included in this study. The prevalence of MTX intolerance was measured by "Methotrexate Intolerance Severity Score" questionaire every 3 months during regular rheumatological examinations. Simultaneously, medical records were reviewed. Data analysis was performed by means of descriptive statistics, correlation dependence and statistical signifikance of dependence was assessed with statistical two-choice...
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Analysis of antibiotic administration in prophylaxis I.
Domecký, Petr ; Malý, Josef (advisor) ; Matoulková, Petra (referee)
8 Abstract Analysis of antibiotic administration in prophylaxis I Author: Petr Domecký Tutor: PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Lucie Hauschke, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Antibiotic prophylaxis (AP) plays an important role in reduction of surgical site infection (SSI). It is the administration of an eligible antibiotic or chemotherapeutic (ATB) in a single dose, usually 30 minutes before surgery, followed by two to three doses during or after the surgery, regarding the selected ATB and the surgical procedure. The aim of this work was to analyse the AP in surgical procedures at the Masaryk Hospital in Ústí nad Labem (MNUL) in the context of the MNUL guideline (DP) and the research on available AP work. Methods: A cross-sectional observational study ran from January 2018 to March 2018 in surgical departments at MNUL. The study included patients aged ≥ 18 years who underwent surgery in a defined period (5 February 2018 to 9 February 2018) and gave their consent to the study. The practicability of the study was verified by a pilot part. Initially, a research of published studies concerning AP was carried out which provided outputs for AP establishment (PPA). Subsequently, a form for...
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Evaluation of the rationality of analgetic treatment in geriatric patients (I.)
Sirka, Pavol ; Fialová, Daniela (advisor) ; Doseděl, Martin (referee)
: INTRODUCTION : Osteoarthritis (OA) is a degenerative disease that predominantly affects geriatric population. However, geriatric patients are not often treated according to specific geriatric recommendations. OA also belongs to highly prevalent disorders managed mostly by symptomatic, analgetic drug treatment. The aim of this diploma thesis was to evaluate to which extend are clinical guidelines for management of OA focused (generallly and in areas of individual pharmacotherapeutic strategies) on specific aspects of rational geriatric pharmacotherapy. Diploma thesis was completed as a recherche thesis (part I.) for follow-up studies dealing with rationality of analgetic drug treatment in older patients (rigorous thesis of M. Miklasová MS, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, 2016). METHOD : 4 national and 3 international clinical guidelines for management of osteoarthritis in accessible languages, published between 2005 and 2014 years, were identified by literature search conducted between 9/2015- 3/2017. Following guidelines were included : czech (2012), german (2009), australian (2009), american (2012) and recommendations of international societies OARSI (2008-2010), EULAR (2005, 2007) and NICE (2014).This diploma...
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