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Quantification of Perfusion using MRI ASL Methods
Kolajová, Martina ; Mézl, Martin (referee) ; Jiřík, Radovan (advisor)
This bachelor thesis deals with quantification of perfusion using a contrast-free MRI technique called „Arterial Spin Labeling“ (ASL). Firstly, the physical principle of magnetic resonance imaging and the concept of perfusion will be described for better understanding of the subject. The next chapters will focus on the ASL method itself and perfusion quantification using mathematical models, namely T1 perfusion and Standard. The algorithm for preprocessing and analysis of selected datasets, designed in the thesis, is implemented using the program MATLAB. Program BASIL was used for further processing. The outputs in the form of perfusion and ATT maps and model fitting processes using various models from both programs are compared and evaluated.
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Simulation of ultrasound sequences in contrast mode
Staňková, Jana ; Mézl, Martin (referee) ; Harabiš, Vratislav (advisor)
This bachelor thesis deals with the principle of contrast imaging techniques for ultrasound imaging. In the first part there are described basic principles and characteristics of ultrasound waves for the understanding. It is also focused on ultrasound contrast agents used in contrast enhanced ultrasound imaging. The important part is the description of perfusion models with a focus on obtaining perfusion parametres and analyzing perfusion curves obtained by measuring the ultrasound contrast agent over time. The second part is devoted to designing a program for generating simulated ultrasound images and description of the simulation of 2D ultrasound tomograms.
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The role of the radiologist assistant in radionuclide brain examination
Horčičková, Zuzana ; Vlček, Petr (referee) ; Špalková, Ingrid (advisor)
Bachelor's thesis "The Role of the radiotherapist in radionuclide brain examinations" is engaged Nuclear medicine imaging methods in the examination of the brain and the role of the radiotherapist at radioisotope nuclear examination in the brain. The work is divided into nine parts. In the first and second part describes anatomy and physiology of the nervous system. The third part is devoted to regional brain blood perfusion - an examination of brain perfusion and assessment of cerebrovascular reserve capacity, which is described preparation and advance in examination, used radiofarmaceutical, evaluation of SPECT examination and contraindication. For testing cerebrovascular reserve capacity are described options burdens. Furthermore, in this chapter refers to the differential diagnostics of dementia, the detection of epileptic focus, the diagnosis of brain death and diagnostics of brain trauma. The fourth part is direct on receptor diagnostics. With respect to commercially supplied by diagnostic ligand is the most common examination dopamine system. The fifth part deals with 18F-FDG - PET examination of the brain. Distribution and intensity of glucose metabolism in the brain can be visualized. The sixth part deals with the diagnosis of brain tumors. In this chapter described the examination using of SPECT...
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Simulation of ultrasound sequences in contrast mode
Staňková, Jana ; Hesko, Branislav (referee) ; Harabiš, Vratislav (advisor)
This bachelor thesis deals with the principle of contrast imaging techniques for ultra-sound imaging. In the first part there are described basic principles and characteristics of ul-trasound waves for the understanding. It is also focused on ultrasound contrast agents used in contrast enhanced ultrasound imaging. The important part is the description of perfusion mo-dels with a focus obtain perfusion parametres and analyze perfusion curves obtained by mea-suring the ultrasound contrast agent over time. The second part is devoted to designing a pro-gram for generating simulated ultrasound images and description of the simulation of 2D ul-trasound tomograms.
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Acquisition, Modeling and Signal Processing in Ultrasound Perfusion Imaging
Mézl, Martin ; Kozubek, Michal (referee) ; Flusser,, Jan (referee) ; Jiřík, Radovan (advisor)
This work deals with possibilities of ultrasound perfusion analysis for the absolute quantification of perfusion parameters. In the theoretical part of this work are discussed possibilities of using of the ultrasound contrast agents and approaches for the perfusion analysis. New methods for the perfusion analysis are suggested and tested in the practical part of this work. The methods are based on convolutional model in which the concentration of the contrast agent is modeled as aconvolution of the arterial input function and the tissue residual function. The feasibility of these methods for the absolute quantification of perfusion parameters is shown on data from phantom studies, simulations and also preclinical and clinical studies. The software for the whole process of the perfusion analysis was developed for using in hospitals.
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Simulation of ultrasound sequences in contrast mode
Staňková, Jana ; Hesko, Branislav (referee) ; Harabiš, Vratislav (advisor)
This bachelor thesis deals with the principle of contrast imaging techniques for ultra-sound imaging. In the first part there are described basic principles and characteristics of ul-trasound waves for the understanding. It is also focused on ultrasound contrast agents used in contrast enhanced ultrasound imaging. The important part is the description of perfusion mo-dels with a focus obtain perfusion parametres and analyze perfusion curves obtained by mea-suring the ultrasound contrast agent over time. The second part is devoted to designing a pro-gram for generating simulated ultrasound images and description of the simulation of 2D ul-trasound tomograms.
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Optimization methods for perfusion parameters estimation.
Bali-Jenčíková, Kateřina ; Kozumplík, Jiří (referee) ; Mézl, Martin (advisor)
The content of this bachelor thesis is research the principles of ultrasound imaging, description of mathematical models that are used to estimate perfusion parameters of concentration curves. Thesis also includes a theoretical analysis of genetic algorithms. In the practical part, solves the realization of global optimization methods and their subsequent evaluation. Implementation was solved by in Matlab.
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Non-contrast MRI perfusion imaging
Kruml, Ondřej ; Jiřík, Radovan (referee) ; Krátká, Lucie (advisor)
This bachelor paper is focused on the magnetic resonance perfusion imaging technic without the usage of an external contrast media. This paper contains a look at the basic functional principle of the magnetic resonance. The focus is then set set on the Arterial Spin Labeling (ASL) technic. The basic principle of ASL uses protons from the water mocelules in arterial blood as an endogenous contrast agent. This technic can be used for obtaining a perfusion map of any tissue without the usage of invasiont echnics or contrast agents. The quantification of perusion was done applying the FAIR-RARE scheme, which belongs to the large family pulsed ASL.
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Advanced signal processing methods in dynamic contrast enhanced magnetic resonance imaging
Bartoš, Michal ; Flusser,, Jan (referee) ; Mlynárik,, Vladimír (referee) ; Jiřík, Radovan (advisor)
Tato dizertační práce představuje metodu zobrazování perfúze magnetickou rezonancí, jež je výkonným nástrojem v diagnostice, především v onkologii. Po ukončení sběru časové sekvence T1-váhovaných obrazů zaznamenávajících distribuci kontrastní látky v těle začíná fáze zpracování dat, která je předmětem této dizertace. Je zde představen teoretický základ fyziologických modelů a modelů akvizice pomocí magnetické rezonance a celý řetězec potřebný k vytvoření obrazů odhadu parametrů perfúze a mikrocirkulace v tkáni. Tato dizertační práce je souborem uveřejněných prací autora přispívajícím k rozvoji metodologie perfúzního zobrazování a zmíněného potřebného teoretického rozboru.
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Phantom model for perfusion imaging
Borovičková, Michaela ; Harabiš, Vratislav (referee) ; Mézl, Martin (advisor)
This work focuses on issues relating to the perfusion analysis. The aim of this work is to perform experimental measurements of the phantom and then evaluate the perfusion curves. This curves are used to himation of perfusion hemodynamic parameters, which indicates important informatik about monitoring area. All processes associated with the designation and evaluation are performed in a program named Matlab. The output of work is a system that provides the reader into the problem of perfusion analysis and allows him to understand and know what is the meaning od analysis, what demands are placed on the evaluation and what is the result of this perfusion analysis.
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