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Nursing care of the petient with bipolar disrorder
Holečková, Barbora ; Kulířová, Veronika (advisor) ; Maffei Svobodová, Ludmila (referee)
Bipolar disorder is a very serious mental disorder defined by mood swing of pathological nature. It is a chronic disorder, which strongly affects daily life of the patient. Its negative effects can impinge personal relationships and ones performance at work. According to WHO the bipolar disorder is the sixth in the list of main causes leading to lifelong disability. Altering between manic and depressive periods is very difficult, not only for the patient, but for the attending staff as well. In my thesis I will give a thorough characterization of the disorder. Theoretical findings on the topic were acquired via carefully done research in National Library of Medicine and via databases PubMed, Medline, Embase and Medvik. Theoretical part of the thesis is also enhanced with testimonies of actual patients with bipolar disorder. Their stories were acquired via books, research papers and internet discussion forums. I will proceed to refer about specific features of nursing practice based on particular case study of 65 years old patient with bipolar disorder. Medical staff has to aid the patient both during the manic and depressive periods while being greatly attentive. It is necessary to carefully observe behavior of the patient, their verbal and nonverbal communication in order to prevent unsolicited...
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Conflict of Responsibility at Social Workers from Fokus.
KUBATOVÁ, Michaela
The thesis deals with the conflict of social worker´s responsibilities in the FOCUS organization. The theoretical part is focused on the characteristics of the organization and the issues of its target group, which is mental illness - schizophrenia and bipolar disorder. It describes the work of social workers with this target group. It also introduces issues conflict, ethical problem, ethical dilemmas and responsibility. The other part of the thesis is empiric, research fosuced on identifying, analyzing and trying to evulaute the conflict of responsibilities of selected social workers of Focus ČB. For data-analysis I used a method of creating groups. According to them, I grouped the information with similar features.
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Genetics of psychic diseases
Krčmářová, Eliška ; Šolc, Roman (advisor) ; Dudová, Iva (referee)
Psychological diseases are very heterogeneus group of diseases, including a complicated and complex multifactorial etiology with a possibility of an important role of a genetic component. Some diaseses got discovered their clear genetic origins, for instance Rett syndrom, where the origins are caused by a mutation in gen MECP2. The origins of a majority of other psychological diseases are more complex - it is chiefly a combination of specific polymorphism of many gens with an impact of an external environment. Among this group we can range diaseases such as anxiety disorder, eating disorder, schizophrenia and bipolar disorder. Autism presents the polymorphism of few different gens, however other mentioned diseases presents mainly polymorphism of genes, connected into neurontransmission. This thesis deals with a selection of potential genetic causes of psychological diseases, illustrated by the specific examples. Keywords: psychological diseases, Rett syndrom, autism, neurotransmitters, anxiety disorder, eating disorders, schizophrenia, bipolar disorder, mutation, polymorphism
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The disruption of the circadian system in bipolar disorder and its association with the polymorphism of L-type calcium channel
Filipovská, Eva ; Bendová, Zdeňka (advisor) ; Novosadová, Zuzana (referee)
Bipolar affective disorder is a serious psychiatric disease with prevalence of about 1% in general population. Typical symptoms are mood changes: manic periods are followed by depressions, with possible asymptomatic period of variable duration between them. It alters patient's everyday life and often leads to suicidal tendencies. Bipolar disorder is related to impaired circadian rhytms that are regulated from suprachiasmatic nuclei in hypothalamus. Impaired circadian rhytms in bipolar disorder are manifested by abnormalities of sleep and daily activity and by disrupted circadian secretion of several hormons. One of many factors that link bipolar disorder to circadian system at molecular level is the function of voltage-dependent calcium channels of L-type. Expression of these channels is regulated by the clock genes and their proper function is important for maintaining endogenous oscillations in the main oscillator located in suprachiasmatic nuclei. A common finding in patients with bipolar disorder is polymorphism of the gene for 1 subunit of the Cav1.2 channel. Abnormal function of calcium channels, consequent to the polymorphism, may be one of the causes that alter circadian rhytms in bipolar disorder. Key words: circadian system, suprachiasmatic nucleus, bipolar disorder, L-type calcium...
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