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The expression of interleukin 20 and its role in rheumatoid arthritis
Yadollahi, Benjamin ; Šenolt, Ladislav (advisor) ; Krulová, Magdaléna (referee)
Rheumatoid arthritis (RA) is a chronic autoimmune disease that is associated with formation of autoantibodies, activation of inflammatory cascade and up-regulation of several cytokines. These processes lead to persistent synovial inflammation, joint damage and systemic manifestations. The aim of this diploma thesis is to characterize the role of a novel cytokine interleukin-20 (IL-20) in the pathogenesis of RA and to investigate its involvement in different stages of the disease as a potential surrogate biomarker. In this work, several methods including Enzyme-Linked Immunosorbent Assay (ELISA), Immunohistochemistry and Real-Time quantitative Polymerase Chain Reaction (RT-qPCR) have been employed. We demonstrated increased expression of IL-20 in the synovial tissue of RA compared with control osteoarthritis (OA) patients. Along with the up-regulation at sites of inflammation, concentrations of IL-20 were higher in the synovial fluid compared with circulating levels of IL-20. Furthermore, serum and synovial fluid IL-20 levels significantly correlated with RA disease activity. Synthesis of IL-20 was significantly increased in peripheral blood mononuclear cells (PBMCs) and synovial fibroblasts upon stimulation with some TLR ligands and pro-inflammatory cytokines. Although not regulating PBMCs functions in...
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Physiotherapy after arthroplasty procedures for rheumatic patients
Suchá, Petra ; Jalovcová, Miroslava (advisor) ; Pavelka, Karel (referee)
Title Physiotherapy after arthroplasty procedures for rheumatic patients. Defining the problem The main problem this thesis solves is to find and compare findings on the practice of physiotherapy in rheumatic patients, patients with rheumatoid arthritis (RA) who have undergone surgery, joint replacement of lower limb arthroplasty, with a focus on the ankle joint. It will be a comparison of the approaches used in the workplace catchment for the Czech Republic, Institute of Rheumatology (RU) in Prague and the world. Aim The aim is to create a comprehensive overview and comparison of physiotherapy procedures used in rheumatic patients who underwent joint replacement legs, zjm. ankle joint, in the CR is in the hands, and in the world and see whether these practices vary significantly, or are identical. The method of solution The work is prepared by comparing the findings relating to the care of patients with available literature. The findings are grouped and arranged tables are created with recording procedures. The work is written in the form of research. Key worlds revmatoidní artritida totální náhrada hlezenního kloubu (TEP) hlezenní kloub fyzioterapie
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Interaction of selected anthocyanidins with farnesoid X receptor
Jeřábková, Jana ; Pávek, Petr (advisor) ; Martin, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Jana Jeřábková Supervisor: Doc. PharmDr. Petr Pávek, Ph.D. Title of diploma thesis: Interaction of selected anthocyanidins with farnesoid X receptor Human farnesoid X receptor (FXR) is a member of nuclear receptor superfamily that act as ligand-activated transcription factors. FXR binds to specific regulatory DNA regions and induces expression of many target genes. These regulated genes are involved in bile acid metabolism and transport, maintaining blood lipids, liporoteins and glucose homeostasis and also contribute to maintain intestinal bacterial balance, hepatoprotection and liver regeneration. The interest of recent studies is to test the range of FXR ligands for treatment and prevention of many diseases such as cholestais, cholesterol gallstone disease, steato-hepatitis, dyslipidemia, atherosclerosis, type 2 diabetes mellitus, metabolic syndrome, liver cancer and other forms of cancer such as breast cancer. In this experimental diploma thesis we are focused on testing of potencial ligands of human farnesoid X receptor from the group of natural plant pigments anthocyanidins (cyanidin, delphinidin, malvidin, pelargonidin, peonidin and petunidin) using the human hepatoma cell line...
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Case study of physiotherapy treatment of a patient with rheumatoid arthritis
Benetková, Hana ; Jalovcová, Miroslava (advisor) ; Jarošová, Hana (referee)
Author: Hana Benetková Title of bachelor's thesis: Case study of physiotherapy treatment of a patient with rheumatoid arthritis Summary: The aim of this bachelor's thesis is to become familiar with the issues of rheumatoid arthritis and develop case study of the patient with this diagnosis. This work is divided into general and special part. General part is focused on etiology, pathogenesis, clinical picture, diagnostics and treatment of rheumatoid arthritis. Special part was compiled on the base of the coherent expert internship at the Rheumatology Institute in Prague during the period from 14.1.2013 to 8.2.2013. This part includes anamnesis, input and output kinesiology analysis, aims and design of the therapy, therapy progress and evaluation of the therapy effect. Key words: rheumatology, rheumatoid arthritis, physiotherapy, case study
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Case report physiotherapy care of a patient diagnosed with polyarthritis with early rheumatoid arthritis
Michálková, Kateřina ; Hnátová, Iva (advisor) ; Jarošová, Hana (referee)
Title of bachelor's thesis: Case report physiotherapy care of a patient diagnosed with polyarthritis with early rheumatoid arthritis. Summary: The bachelor thesis deals with polyarthritis disease with early rheumatoid arthritis and its physiotherapy care. It consists of two parts. The general part contains a general joint anatomy, deals with the major problems of disease and polyarthritis rheumatoid arthritis, its diagnosis, treatment and physiotherapy care. Special part includes a case report of a patient with a diagnosis of polyarthritis with early rheumatoid arthritis. Key words: Polyarthritis, rheumatoid arthritis, physiotherapy.
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Case report on physiotherapy care for a patient diagnosed with rheumatoid arthritis
Svobodná, Magdalena ; Neuwirthová, Svatava (advisor) ; Jarošová, Hana (referee)
Title of bachelor's thesis: Case report on physiotherapy care for a patient diagnosed with rheumatoid arthritis Author: Magdalena Svobodná Thesis supervisor: Mgr. Svatava Neuwirthová Year: 2014 Aim of the thesis: The aim of the thesis is to summarize theoretical knowledge of rheumatoid arthritis in general part of the thesis and to elaborate a case report on a patient diagnosed with the disease, to emphasize physiotherapeutical care within the terms of a complex treatment of the patient and to assess the effects of the therapy in specialized part. Methodology: The first part of the thesis is general one. It deals with etiology and pathogenesis, clinical picture and symptoms, diagnostics and evaluation of patients, course of the disease and komplex treatment of rheumatoid arthritis, namely pharmacotherapy and application of physiotherapeutical procedures. The second, specialized part of the thesis is designed in form of a case report. It involves a medical history, a complete input and output kinesiological analysis of the patient, subsequent plan of therapy, course of 10 therapeutical units and evaluation of the therapy effects. Keywords: case report, physiotherapy, rheumatoid arthritis, rheumatology
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Case of physiotherapy care for patients diagnosed with rheumatoid arthritis and the condition after total hip arthroplasty for traumatic fracture
Žarković, Dragana ; Nováková, Tereza (advisor) ; Jarošová, Hana (referee)
Title of bachelor's thesis : Case of physiotherapy care for patients diagnosed with rheumatoid arthritis and the condition after total hip arthroplasty for traumatic fracture Author : Dragana Žarković Supervisor : PhDr. Tereza Nováková, PhD. Academic year : 2012 Aim : Thesis accentuates the role of the physiotherapist, as part of a team of experts in the care of patients with rheumatoid arthritis, as well as the importance of a comprehensive rehab therapy and possible use of physiotherapy procedures. Part of the thesis is a detailed case report of a patient with rheumatoid arthritis and the condition after total hip arthroplasty for traumatic fracture. Methodics Thesis is divided into general and special parts. The general part is divided in the issue of rheumatology, orthopedics and traumatology, describes the problems of disease and types of surgical procedures. The following section describes the physiotherapy sessions for patients suffering from rheumatic diseases and also after total hip arthroplasty. Special part, case report describes a patient with a diagnosis of rheumatoid arthritis and the condition after total hip arthroplasty for traumatic fracture. This case report was prepared during clinical practice in the Institute of Rheumatology in Prague, in the period from 9.1.2012 to 3.2.2012...
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Epigenetické regulace u autoimunitních onemocnění se zaměřením na revmatoidní artritidu
Horková, Veronika ; Daňková, Pavlína (advisor) ; Hušáková, Markéta (referee)
Exact cause of rheumatoid arthritis, as well as other autoimmune diseases has not been identified yet. In last twenty years, epigenetics showed a new face of immune system. DNA methylation, modification of histones - proteins around which DNA is wrapped, or interference of small RNA sequences - microRNAs, these all are heritable changes outside the DNA sequence that provide another component involved in autoimmunity. Presented epigenetic mechanisms alter gene expression and thus facilitate production of pro- inflammatory factors leading to autoimmune reactions. Moreover, genes regulating apoptosis are also frequently targeted by epigenetic modifications. Not only these mechanisms provide another level of immune defense, they also explain higher female susceptibility to autoimmune diseases and the influence of environment on pathogenesis of these diseases.
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Case report patients diagnosed with rheumatoid arthritis
Váňová, Tereza ; Žáková, Hana (advisor) ; Jarošová, Hana (referee)
Title of bachelors thesis: Case report patients diagnosed with rheumatoid arthritis Summary: The work is focused on diseases rheumatoid arthritis and its physiotherapy care. It consists of two parts. Part of the general anatomy of the joint contains a general, deals with the disease rheumatoid arthritis, its diagnosis, treatment and comprehensive rehabilitation treatment. Part has its own special case report physiotherapy sessions on this topic. Key words: rheumatoid arthritis, comprehensive rehabilitation, physiotherapy Vypracovala: Tereza Vá ová Vedoucí bakalá ské práce: Mgr. Hana Dušková Rok obhajoby: 2012
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Epidemiological aspects of inflammatory rheumatic diseases and diffusional diseases of binding tissue.
Hánová, Petra ; Pavelka, Karel (advisor) ; Bencko, Vladimír (referee) ; Horák, Pavel (referee)
v anglickém jazyce Introduction: No information was known about frequency of common inflammatory disorders in rheumatology in the Czech Republic. Aims of the study: To estimate the standardized annual incidence (INC) and point prevalence (PREV) of six diseases (rheumatoid arthritis-RA, juvenile idiopathic arthritis-JIA, gout, psoriatic arthritis-PsA, ankylosing spondylitis-AS, reactive arthritis-ReA) in a population-based study in two regions of the Czech Republic (CR). Methods: INC: Incident cases were registered on condition that the definite diagnosis was confirmed according to existing classification criteria during the study period. PREV was studied on the basis of identification of established diagnoses at a time point. Crude rates were standardized for age and sex. Results: Both INC and PREV are shown per 100.000 inhabitants. RA INC:31 (95%CI 20-42), PREV:610 (95%CI 561-658). Gout-INC:41 (95%CI 28-53), PREV:300 (95% CI 266-334). JIA-INC: 13 (95% CI 1-20), PREV:140 (95%CI 117-280). PsA-INC:3,6 (95% CI 1-8), PREV:49 (95%CI 40-60). AS-INC:6 (95% CI 3-11), PREV:94 (95% CI 94-109). ReA-INC:9 (95% CI 6-15), PREV:91 (95% CI 78-106). Conclusion: This is the first population-based study estimating annual incidence and prevalence rates of the most common rheumatological disorders in the Czech...
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