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Quality of life in patients with inflammatory bowel diseases
Píchová, Andrea ; Mellanová, Alena (advisor) ; Marková, Eva (referee)
Quality of life in patients with inflammatory bowel disease (IBD) depends on activity, therapy and complications of this chronic disease. Further more it also depends on psychosocial and economic aspects. Nurse plays an important role in education and psychological care for these patients. Aim of this work, based on questionnaire and its statistical processing is to evaluate quality of life of IBD patients (according to age, education and social background) and monitor its dynamics from the time of diagnosis and during treatment of the disease. 1. -6-
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Clinical and genetic predictors of drug dependency in inflammatory bowel disease
Ďuricová, Dana ; Lukáš, Milan (advisor) ; Keil, Radan (referee) ; Špičák, Julius (referee)
IN ENGLISH Drug dependency in inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC), is a specific disease phenotype which determines disease prognosis and hence may be used as a prognostic marker for treatment management. Drug dependency in IBD has been well described in corticosteroid treatment and recently also in infliximab (IFX) therapy. The aims of this thesis were: 1) to assess the occurrence of IFX dependency in paediatric and adult patients with CD; further to search for clinical and genetic predictors of IFX outcome and to evaluate the impact of IFX dependency on surgical rate; 2) to assess in CD patients the outcome of the first course of 5-ASA monotherapy with emphasis on 5-ASA dependency and to define clinical predictors of 5-ASA treatment outcome. We found that 66% of children and 29% of adults with CD became IFX dependent. The high frequency in paediatrics is in agreement with previously published studies, while the finding in adult patients indicates a lower rate of IFX dependency in the only study to date. Perianal disease and no bowel surgery prior to IFX start were predicative of IFX dependency in paediatric patients. In adult cohort, 2 genetic variants LTA c.207 A>G and CASP9 c.93 C>T were associated with IFX outcome, whereas no relevant clinical...
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Quality of life of selected groups of clients with Crohn's disease
Hejlová, Ivana ; Hlaváčová, Marie (advisor) ; Nikodemová, Hana (referee)
My dissertation work called "The quality of life within selected groups of clients with the Crohn's disease" is analysing the subjective evaluation of the clients' life situation, that describes their day-to-day struggle with this chronic disease. This work is divided into two parts, theoretical and empirical. The objective of the former is to present the current findings about the Crohn's disease, to describe the term "quality of life", defines its various meanings and history and specifies the assessment methods in the clinical practice. In the latter, there are set objectives and working hypotheses for own evaluation. The target of the empirical part is to obtain real life data through questioning methods, partly based on the standardised WHQL-BREF methodology. The obtained data will be subjected to primary analysis in order to create an evaluation result for a selected group of clients. In the last part, this dataset will be compared with the previously measured values on quality of life of clients with Crohn's disease.
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