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National Repository of Grey Literature

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	Acyklické bis-fosfonátové nukleosidy - nová analoga ANP Vrbovská, Silvie ; Holý, Antonín As a part of the systematic SAR study in ANP series (many of ANP derivatives posses significant antiviral and cytostatic activity), we intended to study the behavior of ANP analogues bearing in the molecule two phosphonate residues. Detailed record
	Syntéza N4-substituovaných derivátů 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosinu (HPMPC, Cidofovir, Vistide) Chalupová, Šárka ; Holý, Antonín 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) has a broad activity spectrum against DNA viruses. As the systemic drug VireadTM is used for treatment of cytomegalovirus retinitis in AIDS patients. Based on this unique profile of HPMPC we have investigated the effect of the substitution of the amino function at the position 4 upon the antiviral activity. Detailed record
	ANP methods in brewing industry Geschmay, Pavel ; Fiala, Petr (advisor) ; Witz, Karel (referee) Thesis applies methods of ANP in brewing industry. It concentrates on Czech beer market and small local brewery in Policka. Main goal of the thesis is to apply the methods in real life problems from the chosen segment. Work consists of several chapters. First chapter defines the goals of the thesis and describes situation in Policka brewery. Second deals with theory around ANP processes. Third chapter is the main part of the thesis. It applies the theory by solving concrete problems. Last chapter analyzes the results. Detailed record

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