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Fundamental analysis of Erste Bank
Ročková, Naděžda ; Veselá, Jitka (advisor) ; Derner, Tomáš (referee)
This bachelor thesis deals with fundamental analysis of Erste Bank's shares on the Prague Stock Exchange. The first chapter analyses the influence of macroeconomic variables on development of the stock index. In the second chapter attention is paid to banking sector, therefore how its development can influence share price. The last chapter deals with corporate analysis, which using various methods calculates the share's intrinsic value. Based on these partial analyzes is derived investment recommendation relating to Erste Bank shares in conclusion.
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Study of cytotoxicity of potential antituberculotics using selected methods on liver and kidney cell line
Katrnošková, Simona ; Ramos Mandíková, Jana (advisor) ; Bárta, Pavel (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Mgr. Simona Katrnošková Supervisor: PharmDr. Jana Ramos Mandíková, Ph.D. Title of Thesis: Study of cytotoxicity of potential antituberculotics using selected methods on liver and kidney cell line During pharmacologic therapy, tissues of liver and kidney are frequently exposed to high doses of xenobiotics. Via in vitro assays during preclinical testing, we are able to predict potential toxicity which helps to prevent the possible serious adverse drug reactions in clinical practice. The aim of this rigorous thesis was to state the cytotoxic profile of 4 potential antituberculotic drug candidates using appropriate cell models and in vitro assays. Another aim was to compare the cytotoxic effect of the tested compounds among themselves and to 4-aminosalicylic acid (PAS) which antituberculotic activity is known for many years. The tested substances were 3 salicylanilide diethyl phosphate-based derivatives and 4-(trifluormethyl)benzoic acid. For the cytotoxic potential assessment, we used the parameter half maximal inhibitory concentration IC50. We have used methods determining the cell metabolic activity, aminopeptidase activity, lactate dehydrogenase leakage and activity of 3/7 caspases in this...
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Sparse robust portfolio optimization via NLP regularizations
Branda, Martin ; Červinka, Michal ; Schwartz, A.
We deal with investment problems where we minimize a risk measure\nunder a condition on the sparsity of the portfolio. Various risk measures\nare considered including Value-at-Risk and Conditional Value-at-Risk\nunder normal distribution of returns and their robust counterparts are\nderived under moment conditions, all leading to nonconvex objective\nfunctions. We propose four solution approaches: a mixed-integer formulation,\na relaxation of an alternative mixed-integer reformulation and\ntwo NLP regularizations. In a numerical study, we compare their computational\nperformance on a large number of simulated instances taken\nfrom the literature.
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International security with the focus on Islamic region. Searching the premises of the Hizbullah martyrdom on a multilevel analysis
Kočišíková, Viera ; Lehmannová, Zuzana (advisor) ; Eichler, Jan (referee) ; Gombár, Eduard (referee) ; Danics, Štefan (referee)
Most of the existing researches on martyrdom are based on single factor analysis and ignore the fact that this phenomenon is a result of individual psychology and the influence of the environment. That is why most of the researchers aim for multi level approach of the analysis. Only few of them though worked out this approach into a formal model. Although most of the researchers agree that the three level analysis approach is neccessary, most of the researches are based on two level analysis approach. Three level analysis approach was first introduced by Kenneth Waltz (1988) in his research on the causes of war more than fifty years ago. In Waltz model the most fundamental parts neccessary to understand internatinal affairs are individual, state and the state environment. If this is transformed into the matter of terrorist groups we get a three level model of Assaf Moghadam which is based on Waltz's model. In Moghadam's model a state is replaced by a relevant organization and the last level of Waltz's model is replaced by the structural level. Presented thesis is based on the research of Assaf Moghadam and his three level analysis model of suicide terrorism. The main objective of the thesis is the application of Moghadam's model to the martyrdom operations of Hizbullah. Based on this analysis the conditions leading to martyrdom operations of Hizbullah are being searched as well as the level of racionality of these operations is being questioned. The individual level of analysis focuses on the motivation of individuals, the members of Hizbullah who decided to participate in martyrdom operations, deals with the role and impact of charismatic leader and tries to analyse the correlation of poverty and lack of education and martyrdom. It also examines the motivation of individuals and based on the biographic data tries to create a profile of Hizbullah martyr. The organizational/collective level explains the motivation of the organization, Hizbullah, to use martyrdom. The structure and goals of the organization as well as its regional relations and how this context might influence the use of martyrdom are being examined. It deals as well with the forms of indoctrination Hizbullah uses to attract members as well as voters. The transformation of Hizbullah from the radical zealots into a political group, member of government is being portrayed. The structural level analyses external factors derived from the environment that might play role in developing the martyrdom within Hizbullah. The thesis focuses on selected factors such as shi'ite cult of martyrdom, history of shi'a islam connected with oppression, regional history and main historical milestones etc. It shows the examples of martyrdom within the history among both religious and secular groups. Individual and organizational level are closer connected to the martyrdom operation itself than the structural level. Some of the main structural factores are being examined directly on indivual and organizational level. Those important factors are shi'te religion and the cult of martyrdom, conflict with Israel- the occupation of Southern Lebanon, role and impact of other regional powers.
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