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Interdisciplinary relations between mathematics and geography at grammar school: implemented curriculum
Vandrovcová, Jana ; Netrdová, Pavlína (advisor) ; Havelková, Lenka (referee)
This diploma thesis deals with the relations between mathematics and geography in teaching at grammar school at implemented curriculum level. In theoretical part it deals with conceptions of teaching which support connection of educational content of individual subjects as well as general possibilities for realization interdisciplinary relations of mathematics or geography. There are also concrete interdisciplinary relations between mathematics and geography presented and there are identified main reasons why the developing of connection berween the mentioned subjects is important. Problems of the realization interdisciplinary relations at teaching conducts a survey by halfstructured interview with mathematics teachers. Their answers provide the view of realized curriculum and they uncover opportunities and limitations the tachers of mathematics at level of interdisciplinary connection deals with in practice. There are mainly teachers with mathematics and geography qualification, who can give their opinion on relations of these two subjects. There were prepared six lessons in this diploma thesis focused on active use of interdisciplinary relations of mathematics and geography. Then the autor taught it at grammar school and it made practical review of possibilities and restrictions of such teaching....
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Interdisciplinary relations between mathematics and geography at grammar school: intended curriculum
Vandrovcová, Jana ; Netrdová, Pavlína (advisor) ; Havelková, Lenka (referee)
The presented bachelor thesis fosuses on interdisciplinary relations of mathematics and geography in teaching at grammar school. It theoreticcaly defines interdisciplinary relations and terms related with them. Next, it deals with intended (project) curriculum and it analyses mutual linkage between mathematics and geography in RVP G and in selected ŠVP. Next there follows an analyses of mathematics textbooks from the point of view of occurrence of application examples and examples with interdisciplinary themes. Then it focuses more on examples with geography themes. It also presents selected educational materials focused on interdisciplinary relations. keywords: interdisciplinary relations, mathematics, geography, teaching, grammar school
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Molecular genetic studies in colorectal cancer families
Vandrovcová, Jana ; Kohoutová, Milada (advisor) ; Sedláček, Zdeněk (referee) ; Brdička, Radim (referee)
Colorectal cancer (CRC) is one of the most common cancers in industrialized countries and affects men and women almost equally (1). The prognosis for a patient largely depends on the stage of the tumor at the time of diagnosis with the 5-year survival over 90% in cases where the cancer has not spread to the outer wall of the colon, but only 5% for stages where the cancer has spread outside the colon (2). CRC is a complex disease where environmental factors such as diet and lifestyle play an important role (3). Besides these factors, it has been shown that CRC occurs more frequently in certain families and a number of syndromes mainly with Mendelian dominant inheritance, which predispose to CRC development, have been described. The most common syndromes include hereditary non-polyposis CRC (HNPCC), familial adenomatous polyposis (FAP) and MUTYH associated polyposis. CRC develops in a multistep manner over 10-15 years and the tumorigenic process covers a wide range of both premalignant and malignant lesions, such as hyperplastic polyps and adenomas. These lesions are well characterized both morphologically and genetically and can be easily detected and removed by colonoscopy. Even though CRC develops during a long period, carcinomas are usually recognised at advanced stages of tumor development and surgical...
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