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Specifically substituted dendralenes
Toušková, Tereza ; Špulák, Marcel (advisor) ; Pour, Milan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Tereza Toušková Consultant: PharmDr. Marcel Špulák, PhD. Title of Thesis: Dendralenes with specific substitution The aim of my thesis was to develop a method to synthesize parent [3]dendralene with phenyl group in position 2 and hydroxymethyl moiety attached to the double bonds in positions 1, 3 and 5. These hydroxyls were protected as ethers (TBS, then THP) within the building of dendralene chain. The methodology employed for the formation of dendralene core was hydroalumination-iodination, followed by protection of hydroxyl group and subsequent Sonogashira coupling. Because of low yield of key steps in the reaction sequence, the lower stability of iodinated intermediates and the necessity to repeat their preparation, the synthesis of target dendralene was not finished.
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Qualitative and Quantitative Aspects of Adherence to Osteoporosis Treatment
Toušková, Tereza ; Vytřísalová, Magda (advisor) ; Mareš, Jiří (referee) ; Tesař, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Department of Social and Clinical Pharmacy Candidate Mgr. Tereza Toušková Supervisor PharmDr. Magda Vytřísalová, PhD. Title of Doctoral Thesis QUALITATIVE AND QUANTITATIVE ASPECTS OF ADHERENCE TO OSTEOPOROSIS TREATMENT Následuje překlad abstraktu práce do anglického jazyka. Introduction: Non-adherence in the field of osteoporosis (OP) is considerable and it is necessary to deal with it because adequate adherence to the therapy leads to a reduction in the risk of fractures, the number of hospitalizations, and the cost of health care. Monitoring of the adherence is therefore an essential and integral part of patient care. The problem in osteoporotic patients is that 30-50% don't follow the recommendations for proper use of the drugs, which is f.e. for the treatment of oral bisphosphonates (p.o. BIS) essential. Despite the availability of effective pharmacotherapy, approximately half of patients with OP aren't adherent to the treatment regimen and / or discontinue treatment during the first year of use. Many different methods are used for adherence measurement, making the results difficult to compare. There still isn't a "gold standard" in the measurement of adherence, which would be widely used, which would allow relevant data on...
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Cognitive Disorganisation and Insight in Schizophrenia.
Toušková Petrásková, Tereza ; Bob, Petr (advisor) ; Ptáček, Radek (referee) ; Roman, Robert (referee)
Tereza Petrásková Toušková - Cognitive Disorganisation and Insight in Schizophrenia 1 SUMMARY Conscious awareness is related to brain activities represented as unita- ry, integrated and changeable processes reflecting binding of diverse modalities of basic neural informational processes and their subjective components. According to recent research disturbances of self- awareness and conscious experience have a critical role in pathophysi- ology of schizophrenia, which in early stages of the disease mainly in- clude overactivation of the HPA axis. Together these studies suggest that the processes of disrupted awareness and conscious disintegration in schizophrenia likely might be related and represented by similar dis- ruptions on the brain level, which in principle could be explained by various levels of disturbed connectivity and information disintegration that may negatively affect usual patterns of synchronous activity consti- tuting adaptive integrative functions of consciousness. In this context, a purpose of the theoretical part of the disertation is to describe basic neu- robiological mechanisms underlying integrative processes in the brain with its complementarily related mental activities including self- awareness and insight reflecting interrelated processes between mind and brain that implicate...
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Qualitative and Quantitative Aspects of Adherence to Osteoporosis Treatment
Toušková, Tereza ; Vytřísalová, Magda (advisor) ; Mareš, Jiří (referee) ; Tesař, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Department of Social and Clinical Pharmacy Candidate Mgr. Tereza Toušková Supervisor PharmDr. Magda Vytřísalová, PhD. Title of Doctoral Thesis QUALITATIVE AND QUANTITATIVE ASPECTS OF ADHERENCE TO OSTEOPOROSIS TREATMENT Následuje překlad abstraktu práce do anglického jazyka. Introduction: Non-adherence in the field of osteoporosis (OP) is considerable and it is necessary to deal with it because adequate adherence to the therapy leads to a reduction in the risk of fractures, the number of hospitalizations, and the cost of health care. Monitoring of the adherence is therefore an essential and integral part of patient care. The problem in osteoporotic patients is that 30-50% don't follow the recommendations for proper use of the drugs, which is f.e. for the treatment of oral bisphosphonates (p.o. BIS) essential. Despite the availability of effective pharmacotherapy, approximately half of patients with OP aren't adherent to the treatment regimen and / or discontinue treatment during the first year of use. Many different methods are used for adherence measurement, making the results difficult to compare. There still isn't a "gold standard" in the measurement of adherence, which would be widely used, which would allow relevant data on...
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Specifically substituted dendralenes
Toušková, Tereza ; Špulák, Marcel (advisor) ; Pour, Milan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Tereza Toušková Consultant: PharmDr. Marcel Špulák, PhD. Title of Thesis: Dendralenes with specific substitution The aim of my thesis was to develop a method to synthesize parent [3]dendralene with phenyl group in position 2 and hydroxymethyl moiety attached to the double bonds in positions 1, 3 and 5. These hydroxyls were protected as ethers (TBS, then THP) within the building of dendralene chain. The methodology employed for the formation of dendralene core was hydroalumination-iodination, followed by protection of hydroxyl group and subsequent Sonogashira coupling. Because of low yield of key steps in the reaction sequence, the lower stability of iodinated intermediates and the necessity to repeat their preparation, the synthesis of target dendralene was not finished.
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