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Multipurpose Town House on Křížová Street, Brno
Poruba, Martin ; Němec, Josef (referee) ; Ruller, Ivan (advisor)
Design Theory 1st WHAT IS THE TOWN HOUSE By Town House (the only no MD) is undoubtedly the "parterre". The parterre is meant the space where the public associates with a freelancer (the owner of the house rules), which produces original products and original services. The advantage of this arrangement is just the comfort of home owners who meet only a few steps and is in its own business. Up to then follow the floors for residential owners and floor suitable for extended family living or for rent. The building can be rented for parts. The bottom line is that at least one of the apartments will be permanently residing owner. This is achieved by real form MD. The possibility of phased construction, in principle, helps to achieve optimal distribution of project funding (see figure below), ie. There is no need to invest at a time. It is important to fill the empty land in the streets of the city the right partner, with a gradual hill floor living, creating and MD. Just like in nature and in grow houses in the same way. Live to see if any of them, it is easy to replace by a new town house in a relatively short period of time. 2nd TRANSPORT VISION January 2 The need for transport for the urban man City man living in MD would be able to travel virtually anywhere on foot. Common goals, which during the day or week Stakes should be available nearby. She would arise from the need to own a personal vehicle for city driving. So the MD automatically receives the imaginary top of the pyramid forms of housing. Living it has many advantages. I would venture to say that owning a house might be the goal of each of us. As the owner of MD do not happen to work, ie. carry him away from home. All comfort is located in the vicinity. This form of housing support retail development and maintenance of interpersonal relationships. It is a healthy way of life. Basically I'm trying to point out the long years of proven experience. February 2 Future Transport When thinking about the future of transportation, I think of flying caps, with automatic navigation. Today we may seem too fantasy, but it can be assumed that this direction for the future traffic will develop. Such a concept of urban transport is therefore clear that it will be necessary to invest large sums in building road corridors and the streets will again become a pleasant place for people to meet. Just imagine the morning when you come to lift the roof of the MD and sit at sunrise in your hovercraft ... amazing! If you stay in the country, even today there are solutions that will relieve traffic in the city. Good public transport will solve many. Congestion nodes not in the inner cities, what to do. MHD What should be: efficient, clean, for an annual pass with the support price At least busy line should be abolished and congested lines strengthened, leading to migration of people into urban centers. It is a challenge for city planners. A sufficient number of seats in vehicles is a necessary condition for successful public transport. Cars with low starting edge and in good technical condition are showcase quality public transport. Bicycle hire Following the example of many EU countries, we should consider for transportation by bicycle wheels. Bike rentals should be the norm. RENTAL MOTOR UNIVERSAL MINI carts Likewise, the creation of citywide rental carts with electric motor at low speed 25 km / h would be very beneficial.
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Biologically Active Metabolites of Plants V. Alkaloids from Eschscholtzia californica CHAM. and their Biological Activity
Poruba, Martin ; Cahlíková, Lucie (advisor) ; Opletal, Lubomír (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Botany and Ecology Candidate: Mgr. Martin Poruba Consultant: Ing. Lucie Cahlíková, Ph.D. Title of thesis: Biologically Active Metabolites of Plants V. Alkaloids from Eschscholtzia californica CHAM. and their Biological Activity The aim of this thesis was to treat the mixture of tertiary isochinoline alkaloids from the species Eschscholtzia californica CHAM. (Papaveraceae). Three pure alkaloids were isolated by using common chromatografic methods. The alkaloids were identified by MS and 1-D and 2-D NMR methods. The first isolated alkaloid was identified as tertiary alkaloid protopine, the second as tertiary alkaloid eschscholtzine and the last one as O-methylcaryachine. All of the alkaloids were tested on ability to inhibit human erythrocytic acetylcholinesterase (HuAChE) and serum butyrylcholinesterase (HuBuChE). The inhibition activities for protopine were determined IC50= 423 ± 10,5 μM (HuAChE) and IC50= 333 ± 3,3 μM (HuBuChE). The values of inhibition for alkaloid eschscholtzine were determined IC50= 519 ± 5,8 μM (HuAChE) and IC50>1 mM (HuBuChE). And for O-methylcaryachine the values of inhibition were determined IC50= 498 ± 7,1μM (HuAChE) and IC50>1 mM (HuBuChE). The values of IC50 for...
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Biological activity of plants metabolites. XVIII. Alkaloids of Corydalis yanhusuo W. T. WANG.
Poruba, Martin ; Opletal, Lubomír (advisor) ; Siatka, Tomáš (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Martin Poruba Consultant: Doc. RNDr. Lubomír Opletal, CSc. Title of Thesis: Biological activity of plants metabolites XVIII. Alkaloids of Corydalis yanhusuo W.T.WANG. Cholinesterase inhibitors are the only approved drugs for treating patiens with mild to moderately severe Alzheimer's disease (AD). The cholinergic hypothesis postulates that memory impairment in patiens with AD result from a deficit of cholinergic function in the brain. A decrease of neurotransmitter acetylcholine (ACh) in the brain of patiens with AD appers to be a critical element in producing dementia. Acetylcholinesterase inhibitors can restore the level of acetylcholine by inhibiting acetylcholinesterase. In the screening of natural inhibitors of acetylcholinesterase, alkaloid extracts from species of Papaverales have demonstrated important AChE inhibitory activity. The summary extract of alkaloids was prepared from the dry tubers of Corydalis yanhusuo (10,8 kg). The ethanolic extract was fractionated to get weak-, medium and hight-basic alkaloids and chlorides of quarternary bases. From the diethylether fraction (pH 12) of alkaloids were isolated two known alkaloids: palmatine (CAS 3486-67-7) and...
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Biologically Active Metabolites of Plants V. Alkaloids from Eschscholtzia californica CHAM. and their Biological Activity
Poruba, Martin ; Cahlíková, Lucie (advisor) ; Opletal, Lubomír (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Botany and Ecology Candidate: Mgr. Martin Poruba Consultant: Ing. Lucie Cahlíková, Ph.D. Title of thesis: Biologically Active Metabolites of Plants V. Alkaloids from Eschscholtzia californica CHAM. and their Biological Activity The aim of this thesis was to treat the mixture of tertiary isochinoline alkaloids from the species Eschscholtzia californica CHAM. (Papaveraceae). Three pure alkaloids were isolated by using common chromatografic methods. The alkaloids were identified by MS and 1-D and 2-D NMR methods. The first isolated alkaloid was identified as tertiary alkaloid protopine, the second as tertiary alkaloid eschscholtzine and the last one as O-methylcaryachine. All of the alkaloids were tested on ability to inhibit human erythrocytic acetylcholinesterase (HuAChE) and serum butyrylcholinesterase (HuBuChE). The inhibition activities for protopine were determined IC50= 423 ± 10,5 μM (HuAChE) and IC50= 333 ± 3,3 μM (HuBuChE). The values of inhibition for alkaloid eschscholtzine were determined IC50= 519 ± 5,8 μM (HuAChE) and IC50>1 mM (HuBuChE). And for O-methylcaryachine the values of inhibition were determined IC50= 498 ± 7,1μM (HuAChE) and IC50>1 mM (HuBuChE). The values of IC50 for...
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Biological activity of plants metabolites. XVIII. Alkaloids of Corydalis yanhusuo W. T. WANG.
Poruba, Martin ; Opletal, Lubomír (advisor) ; Siatka, Tomáš (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Martin Poruba Consultant: Doc. RNDr. Lubomír Opletal, CSc. Title of Thesis: Biological activity of plants metabolites XVIII. Alkaloids of Corydalis yanhusuo W.T.WANG. Cholinesterase inhibitors are the only approved drugs for treating patiens with mild to moderately severe Alzheimer's disease (AD). The cholinergic hypothesis postulates that memory impairment in patiens with AD result from a deficit of cholinergic function in the brain. A decrease of neurotransmitter acetylcholine (ACh) in the brain of patiens with AD appers to be a critical element in producing dementia. Acetylcholinesterase inhibitors can restore the level of acetylcholine by inhibiting acetylcholinesterase. In the screening of natural inhibitors of acetylcholinesterase, alkaloid extracts from species of Papaverales have demonstrated important AChE inhibitory activity. The summary extract of alkaloids was prepared from the dry tubers of Corydalis yanhusuo (10,8 kg). The ethanolic extract was fractionated to get weak-, medium and hight-basic alkaloids and chlorides of quarternary bases. From the diethylether fraction (pH 12) of alkaloids were isolated two known alkaloids: palmatine (CAS 3486-67-7) and...
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Multipurpose Town House on Křížová Street, Brno
Poruba, Martin ; Němec, Josef (referee) ; Ruller, Ivan (advisor)
Design Theory 1st WHAT IS THE TOWN HOUSE By Town House (the only no MD) is undoubtedly the "parterre". The parterre is meant the space where the public associates with a freelancer (the owner of the house rules), which produces original products and original services. The advantage of this arrangement is just the comfort of home owners who meet only a few steps and is in its own business. Up to then follow the floors for residential owners and floor suitable for extended family living or for rent. The building can be rented for parts. The bottom line is that at least one of the apartments will be permanently residing owner. This is achieved by real form MD. The possibility of phased construction, in principle, helps to achieve optimal distribution of project funding (see figure below), ie. There is no need to invest at a time. It is important to fill the empty land in the streets of the city the right partner, with a gradual hill floor living, creating and MD. Just like in nature and in grow houses in the same way. Live to see if any of them, it is easy to replace by a new town house in a relatively short period of time. 2nd TRANSPORT VISION January 2 The need for transport for the urban man City man living in MD would be able to travel virtually anywhere on foot. Common goals, which during the day or week Stakes should be available nearby. She would arise from the need to own a personal vehicle for city driving. So the MD automatically receives the imaginary top of the pyramid forms of housing. Living it has many advantages. I would venture to say that owning a house might be the goal of each of us. As the owner of MD do not happen to work, ie. carry him away from home. All comfort is located in the vicinity. This form of housing support retail development and maintenance of interpersonal relationships. It is a healthy way of life. Basically I'm trying to point out the long years of proven experience. February 2 Future Transport When thinking about the future of transportation, I think of flying caps, with automatic navigation. Today we may seem too fantasy, but it can be assumed that this direction for the future traffic will develop. Such a concept of urban transport is therefore clear that it will be necessary to invest large sums in building road corridors and the streets will again become a pleasant place for people to meet. Just imagine the morning when you come to lift the roof of the MD and sit at sunrise in your hovercraft ... amazing! If you stay in the country, even today there are solutions that will relieve traffic in the city. Good public transport will solve many. Congestion nodes not in the inner cities, what to do. MHD What should be: efficient, clean, for an annual pass with the support price At least busy line should be abolished and congested lines strengthened, leading to migration of people into urban centers. It is a challenge for city planners. A sufficient number of seats in vehicles is a necessary condition for successful public transport. Cars with low starting edge and in good technical condition are showcase quality public transport. Bicycle hire Following the example of many EU countries, we should consider for transportation by bicycle wheels. Bike rentals should be the norm. RENTAL MOTOR UNIVERSAL MINI carts Likewise, the creation of citywide rental carts with electric motor at low speed 25 km / h would be very beneficial.
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