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Bonding and non-bonding interaction potentials for simulations of coarse-grained protein models
Pavlíková, Markéta ; Nová, Lucie (advisor) ; Bačová, Petra (referee)
Protein folding involves the transformation of an amino acid chain to a unique 3D structure. The conformation of a protein is determined by its amino acid sequence. Understanding the process of protein folding and dynamics is crucial since protein function is closely related to its structure and dynamics. These processes can be investigated by means of molecular simulations. Coarse- grained models, which are used in molecular simulations, provide a favorable trade-off between computational efficiency and accuracy. To employ such mod- els, a reasonable force field is necessary. The force field includes both bonding and non-bonding interaction potentials, which are derived either from atomistic simulations or from known, experimentally determined protein structures. We derived such potentials using dataset of more than 4,500 structures from PDB database. 1
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Ethical Dilemmas of Using Humanitarian Drones
Pavlíková, Markéta ; Střítecký, Vít (advisor) ; Hynek, Nikola (referee)
Unmanned aircraft vehicles were primarily used for military purposes and are still used for them. Not only for this reason is their introduction for humanitarian aims disputable, raising various dilemmas. Supporters of humanitarian drones put emphasis on/emphasize their speed, security, data amount and the possible employment of new technology in extreme environments. Critics of humanitarian technologization stress the loss of neutrality and impartiality, politicization and militarization of humanitarian aid. Consensus does not even exist amongst academics in the field. Contemporary literature is primarily targeted on the controversy of dual-usage of UAVs and on potential technical advantages with emphasis on immediate assistance. The literature dealing with ethical issues of humanitarian drones in connection to humanitarian and development practice outside the conflict zone is almost absent, and only marginally or indirectly treats the issue. The aim of this paper is to analyse potential advantages and disadvantages of humanitarian drones' proliferation within the theoretical framework of The Code of Conduct for the International Red Cross and Red Crescent Movement and Non-Governmental Organizations in Disaster Relief, which deals with basic dilemmas in humanitarian aid. This thesis does not...
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Speech intervention for adults with dementia
Pavlíková, Markéta ; Klenková, Jiřina (referee)
Univerzita Karlova Pedagogická fakulta Katedra speciální pedagogiky RIGORÓZNÍ PRÁCE Logopedická intervence u dospělých osob s demencí Speech therapy for adults with dementia Mgr. Markéta Pavlíková Konzultant práce: doc. PaedDr. Jiřina Klenková, PhD. Studijní program: Integrované studium speciální pedagogiky Studijní obor: Speciální pedagogika 1 ABSTRACT The thesis describes speech intervention for adults with dementia. The aim of the work and the research is to analyze speech intervention for adults with dementia and family cooperation in clinical speech therapy. The research is conducted through evaluation of questionnaires filled in by family members of patients studied and the subsequent evaluation of the benefits of speech therapy intervention provided both clinical speech therapist and trained family members. When processing techniques were used document analysis, analysis of results of operations, interviews with family members and observation. The aim of the thesis is to demonstrate, how much they may be useful interested, informed and cooperating family and how they can be routed speech therapy. KEYWORDS speech therapy, communication, intervention, neurodegenerative diseases, dementia, Alzheimer's disease, family
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Ethical Dilemmas of Using Humanitarian Drones
Pavlíková, Markéta ; Střítecký, Vít (advisor) ; Hynek, Nikola (referee)
Unmanned aircraft vehicles were primarily used for military purposes and are still used for them. Not only for this reason is their introduction for humanitarian aims disputable, raising various dilemmas. Supporters of humanitarian drones put emphasis on/emphasize their speed, security, data amount and the possible employment of new technology in extreme environments. Critics of humanitarian technologization stress the loss of neutrality and impartiality, politicization and militarization of humanitarian aid. Consensus does not even exist amongst academics in the field. Contemporary literature is primarily targeted on the controversy of dual-usage of UAVs and on potential technical advantages with emphasis on immediate assistance. The literature dealing with ethical issues of humanitarian drones in connection to humanitarian and development practice outside the conflict zone is almost absent, and only marginally or indirectly treats the issue. The aim of this paper is to analyse potential advantages and disadvantages of humanitarian drones' proliferation within the theoretical framework of The Code of Conduct for the International Red Cross and Red Crescent Movement and Non-Governmental Organizations in Disaster Relief, which deals with basic dilemmas in humanitarian aid. This thesis does not...
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