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MDOC and its effects on atherogenic process in mouse model of atherosclerosis.
Nosková, Zuzana ; Nachtigal, Petr (advisor) ; Kopecký, Martin (referee)
Atherosclerosis belongs to the cardiovascular diseases, which have been the most frequent cause of the morbidity and mortality in all the economically advanced countries of Europe and the USA in the last few years. The aim of this diploma thesis was to find some potential hypolipidemic and antiinflammatory effects of MDOC. The new potential substance belongs to the group of dietary fibre. ApoE-deficient mice were fed with atherogenic diet (Western type diet), contained 21% fats (11% full fatty acids) and 0.15% cholesterol for eight weaks (control group). In MDOC group mice were fed by the same atherogenic diet, supplemented with 5% MDOC every day. Biochemical analysis of blood and imunohistochemical and stereological analysis of endothelial expression of VCAM-1 in aortic sinus and aortic arch were performed. MDOC treatment resulted in significant decrease of total cholesterol and triglycerides. On the other hand MDOC treatment did not affect atherosclerotic lesion size measured by oil red area. Moreover MDOC treatment did not affect VCAM-1 expression as well. The results of this diploma thesis indicate that MDOC possess hypolipidemic effects. However this hypolipidemic effect is not sufficient to influence atherogenesis in the vessel wall in these mice. The possible explanation could be either in...
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The effect of daunorubicine on expresion of adhesive molecules in rabit model of anthracycline toxicity
Nosková, Zuzana ; Nachtigal, Petr (advisor) ; Štaud, František (referee)
The aim of this thesis was to evaluate possible changes of cell adhesion molecules expression in rabbit aorta after the administration of Daunorubicin. We focused on the expression of VCAM-1 and ICAM-1. Chronic anthracycline cardiotoxicity was induced by repeated administration of daunorubicinu (3 mg/kg=50 mg/m2 i.v., 1x week) for the period of 10 weeks. We focused on the monitoring VCAM-1 and ICAM-1 expression in rabbit aorta. Ten daunorubicin groups were compared with control rabbits. The animals were killed 24 hours and/or 7 days after the administration of daunorubicin. Immunohistochemical analysis showed no expression of VCAM-1 in any control or experimental groups. On the contrary the expression of ICAM-1 was detected in control and experimental groups. There was no significant difference between experimental and control rabbits with respect to the intensity and staining patterns. In conclusion the administration of daunorubicin did not affect either VCAM-1 or ICAM-1 expression in aorta suggesting that endothelial dysfunction in aorta is not triggered by daunorubicin in vivo.
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MDOC and its effects on atherogenic process in mouse model of atherosclerosis.
Nosková, Zuzana ; Nachtigal, Petr (advisor) ; Kopecký, Martin (referee)
Atherosclerosis belongs to the cardiovascular diseases, which have been the most frequent cause of the morbidity and mortality in all the economically advanced countries of Europe and the USA in the last few years. The aim of this diploma thesis was to find some potential hypolipidemic and antiinflammatory effects of MDOC. The new potential substance belongs to the group of dietary fibre. ApoE-deficient mice were fed with atherogenic diet (Western type diet), contained 21% fats (11% full fatty acids) and 0.15% cholesterol for eight weaks (control group). In MDOC group mice were fed by the same atherogenic diet, supplemented with 5% MDOC every day. Biochemical analysis of blood and imunohistochemical and stereological analysis of endothelial expression of VCAM-1 in aortic sinus and aortic arch were performed. MDOC treatment resulted in significant decrease of total cholesterol and triglycerides. On the other hand MDOC treatment did not affect atherosclerotic lesion size measured by oil red area. Moreover MDOC treatment did not affect VCAM-1 expression as well. The results of this diploma thesis indicate that MDOC possess hypolipidemic effects. However this hypolipidemic effect is not sufficient to influence atherogenesis in the vessel wall in these mice. The possible explanation could be either in...
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The effect of daunorubicine on expresion of adhesive molecules in rabit model of anthracycline toxicity
Nosková, Zuzana ; Nachtigal, Petr (advisor) ; Štaud, František (referee)
The aim of this thesis was to evaluate possible changes of cell adhesion molecules expression in rabbit aorta after the administration of Daunorubicin. We focused on the expression of VCAM-1 and ICAM-1. Chronic anthracycline cardiotoxicity was induced by repeated administration of daunorubicinu (3 mg/kg=50 mg/m2 i.v., 1x week) for the period of 10 weeks. We focused on the monitoring VCAM-1 and ICAM-1 expression in rabbit aorta. Ten daunorubicin groups were compared with control rabbits. The animals were killed 24 hours and/or 7 days after the administration of daunorubicin. Immunohistochemical analysis showed no expression of VCAM-1 in any control or experimental groups. On the contrary the expression of ICAM-1 was detected in control and experimental groups. There was no significant difference between experimental and control rabbits with respect to the intensity and staining patterns. In conclusion the administration of daunorubicin did not affect either VCAM-1 or ICAM-1 expression in aorta suggesting that endothelial dysfunction in aorta is not triggered by daunorubicin in vivo.
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Guerilla marketing and its legal and advertising aspects
Nosková, Zuzana ; Boháček, Martin (advisor) ; Postler, Milan (referee)
The theme of this thesis is "Guerilla marketing and its legal and advertising aspects". Guerilla marketing is a type of marketing tool used for nontraditional, innovative and sometimes shocking advertising campaigns. This thesis contains an analysis of the legal environment regulating this subject. Legal regulation of advertisement in the Czech Republic is a part of both the public and private law regulation. As a part of the thesis a questionnaire survey among the general public was carried out, the public was questioned about knowledge of the concept of guerilla marketing. Another part of the survey was carried out among professionals from communication agencies, their views of the current situation on the advertising market have been compiled. The practical part is concluded by a comparison of the Czech legislation with the legal regulation of advertising in American law.
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Association of unit owners and their rights and obligations
Nosková, Zuzana ; Žák, Květoslav (advisor) ; Vodička, Jan (referee)
This bachelor thesis deals with issues related to Association of unit owners. The aim is to provide an overview of what is the legislation of this area, what are the conditions for the establishment of Association and what is its function. The key issue is the definition and clarification of the concept of management of the house. Marginally is mentioned the historical development of Association and also is compared Czech and Slovak definition of the concept of Association of unit owners according to different laws.
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