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Opportunities to Develop Tourism in Protected Areas
Niklová, Pavlína ; Fialová, Dana (advisor) ; Kučera, Zdeněk (referee)
The thesis is devoted to the issue of tourism development in areas with specific protection. Due to the massive development of tourism, it is necessary to focus on its negative effects, which should be avoided. The performance is therefore sustainable tourism development, which proclaims the idea of preserving existing tourism attractions to future generations. Based on field research, structured interviews and questionnaires with tourism stakeholders identified the status of tourism in protected natural areas in the Czech Republic. Subsequently, the proposed options for tourism development in these areas. A case study is focused on the tourist neglected protected landscape area of Iron Mountain. Keywords: tourism, sustainable tourism, nature conservation area, Iron Mountain
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Pyrazine derivatives as potential drugs I.
Niklová, Pavlína ; Doležal, Martin (advisor) ; Miletín, Miroslav (referee)
Charles University Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Author: Pavlína Niklová Supervisor: prof. PharmDr. Martin Doležal, Ph.D. Title of diploma thesis: Pyrazine Derivatives as Potential Drugs I. Tuberculosis is serious global problem especially due to its fast resistance development to currently used drugs. Therefore drugs used in therapy are only used in combinations to avoid any possible complications due to treatment failure. In addition, global research is focused on finding new potentially successful drugs with sufficient activity against Mycobacterium tuberculosis, main cause of the disease, and acceptable safety, therefore suitable for use in TBC therapy. Research conducted at the Department of Pharmaceutical Chemistry and Pharmaceutical Analysis of Faculty of Pharmacy in Hradec Kralove, Charles University is focused on the synthesis of potential new antituberculotics, especially pyrazine derivatives. This study deals with the synthesis of five aminopyrazine derivatives by the reaction of aminopyrazine with different alkyl substituted isocyanates using microwave reactor. All of the synthesized compounds were characterized by their melting point, elementar analysis, IR spectra and NMR spectra and then tested in vitro for...
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Opportunities to Develop Tourism in Protected Areas
Niklová, Pavlína ; Fialová, Dana (advisor) ; Kučera, Zdeněk (referee)
The thesis is devoted to the issue of tourism development in areas with specific protection. Due to the massive development of tourism, it is necessary to focus on its negative effects, which should be avoided. The performance is therefore sustainable tourism development, which proclaims the idea of preserving existing tourism attractions to future generations. Based on field research, structured interviews and questionnaires with tourism stakeholders identified the status of tourism in protected natural areas in the Czech Republic. Subsequently, the proposed options for tourism development in these areas. A case study is focused on the tourist neglected protected landscape area of Iron Mountain. Keywords: tourism, sustainable tourism, nature conservation area, Iron Mountain
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